Ordering the Rickettsia rickettsii and felis/typhi PCR | New York
Ordering this test helps detect DNA from Rickettsia rickettsii, Rickettsia felis, and Rickettsia typhi, which are bacteria linked to tick- and flea-borne diseases like Rocky Mountain spotted fever and murine typhus. Interestingly, PCR testing can identify these infections even before antibodies appear, which can be especially helpful for early detection.
Ordering this test offers several specific benefits:
- Detects active infection by identifying bacterial DNA, not just immune response.
- Helps guide treatment decisions by confirming the exact type of Rickettsia present.
- Reduces the risk of complications by allowing for earlier intervention.
- Supports differential diagnosis when symptoms overlap with other vector-borne diseases.
- Provides results even if antibiotics have already been started, unlike some antibody tests.
Who Should Consider Rickettsial PCR and Related Tick-Borne Disease Testing
A person who recently spent time hiking in wooded areas and now has a sudden fever, headache, and a spotted rash may want to know if a tick-borne infection is the cause. This test can help clarify the diagnosis and guide the next steps.
Other scenarios where ordering this test may be helpful include:
- Someone with unexplained fever and muscle pain after a camping trip.
- A person with a history of tick or flea exposure who develops skin lesions and swollen lymph nodes.
- Children or adults with persistent flu-like symptoms that do not improve with standard care.
- People living in or traveling to areas where Rocky Mountain spotted fever or murine typhus are more common.
- Someone with a new sensitivity to light and confusion after a recent outdoor event, which can sometimes be linked to rickettsial infections.
Ordering this test can help confirm or rule out a rickettsial infection, which is important for choosing the right treatment and avoiding unnecessary antibiotics. Delaying this test may lead to missed or late diagnosis, which can make symptoms harder to manage and increase the risk of complications. Take the next step by ordering when symptoms or exposure history match these scenarios.
Preparing for Tick and Flea-Borne Bacteria PCR Screening
Fasting is not required for this test, so you can eat and drink as usual before your sample is collected. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Rickettsia rickettsii and felis/typhi PCR
| Test Name | Reference Range | What the Marker Means | Low and High Levels of Rickettsia rickettsii and felis/typhi PCR |
|---|---|---|---|
| Rickettsia rickettsii DNA (PCR) | Not detected | This test looks for the genetic material of Rickettsia rickettsii, the bacteria that causes Rocky Mountain spotted fever. Detecting DNA means the bacteria is present in the sample. |
High levels mean the bacteria is present and an active infection is likely.
Low levels mean the bacteria was not found, making an active infection less likely. |
| Rickettsia felis/typhi DNA (PCR) | Not detected | This marker checks for the DNA of Rickettsia felis and Rickettsia typhi, which are linked to flea-borne spotted fever and murine typhus. A positive result means the bacteria is present in the sample. |
High levels mean an active infection with Rickettsia felis or typhi is likely.
Low levels mean these bacteria were not found in the sample. |
Reference ranges may change slightly as labs update their methods and standards.
Rickettsia rickettsii and felis/typhi PCR FAQ
Is there Rickettsia rickettsii and felis/typhi PCR testing near me?
This is a test kit that can be collected at a local draw site—see the draw location link at the top of the page. Because symptoms like fever and rash can appear quickly after exposure, having a nearby collection option makes it easier to get tested without delay.
How do I interpret the test results?
While your treating physician should always review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, but draw fees may apply. Ordering this test can help you get answers sooner, which is important for starting the right treatment if a rickettsial infection is present.
How often should I retest?
Retesting is usually recommended if symptoms return or if there is a new exposure to ticks or fleas, especially during peak seasons. Repeating the test can help confirm if a new infection has occurred or if treatment has been effective.
How accurate is the test?
This test uses polymerase chain reaction (PCR) to detect bacterial DNA, with a sensitivity of 95% and specificity of 98%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
Note: Only R. rickettsii will be reported for residents of New York
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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