Ordering the Leaky Gut Test | Lactulose/Mannitol | New York
The Leaky Gut Test | Lactulose/Mannitol | New York helps measure how well your small intestine absorbs nutrients and keeps out unwanted particles. This test is often used to check for issues like poor nutrient absorption, food sensitivities, and digestive discomfort. Interestingly, the test uses two sugars—lactulose and mannitol—because they are absorbed differently, which helps pinpoint where the gut barrier may be weak.
Ordering this test can help you:
- Identify if your gut lining is letting larger molecules pass through, which may cause immune reactions.
- Find out if your body is absorbing nutrients properly, which can affect energy and digestion.
- Track changes in gut health over time, especially if you are making diet or lifestyle changes.
- Detect hidden gut issues that may not show up on other tests.
- Support your doctor in creating a more targeted treatment plan for digestive symptoms.
Who Should Consider Intestinal Permeability and Absorption Testing
People who have ongoing bloating, stomach pain, or unexplained tiredness may benefit from this test. For example, someone who has tried different diets and still feels gassy or tired after eating could use this test to find out if their gut lining is letting in things it shouldn’t.
Ordering this test may also be helpful if you:
- Have frequent diarrhea or constipation that doesn’t improve with simple changes.
- Notice skin rashes or breakouts that seem linked to what you eat.
- Experience brain fog or trouble focusing after meals.
- Have a history of autoimmune conditions or food allergies.
- Recently took antibiotics and now have new digestive symptoms, as antibiotics can sometimes change gut barrier function.
Pinpointing gut barrier problems can help you and your doctor make specific changes to improve nutrient absorption and reduce unwanted symptoms. Delaying this test could mean missing early signs of gut issues, which may make symptoms harder to manage later.
Preparing for Gut Barrier and Absorption Lab Testing
Fasting is required for at least 8 hours before starting the test, and you should avoid certain foods like strawberries, celery, and mushrooms for 48 hours before collecting your sample. Always follow any instructions your doctor or healthcare provider gives you to make sure your results are as helpful as possible.
Labs Included When Ordering Your Leaky Gut Test | Lactulose/Mannitol | New York
Test Name | Reference Range | What This Marker Means | Low and High Levels of Leaky Gut Test | Lactulose/Mannitol | New York |
---|---|---|---|
Lactulose | <0.3 | Lactulose is a large sugar molecule that should not be absorbed much by a healthy gut. High levels in urine show the gut wall is letting in larger particles. |
High levels mean the gut lining is more open than normal, which can let unwanted substances into the body.
Low levels mean the gut barrier is working well and not letting large molecules pass through. |
Mannitol | 0.5–2.0 | Mannitol is a small sugar molecule that is easily absorbed by a healthy gut. It helps show how well the gut takes in nutrients. |
High levels mean the gut is absorbing nutrients well.
Low levels mean there may be a problem with nutrient absorption in the small intestine. |
Lactulose/Mannitol Ratio | <0.07 | This ratio compares how much lactulose and mannitol are absorbed. It is the main marker for gut barrier function and permeability. |
High levels mean the gut is more permeable, which can allow larger molecules to pass through.
Low levels mean the gut barrier is likely intact and working as it should. |
Creatinine | 0.5–2.0 | Creatinine is used to check if the urine sample is collected properly and to adjust the results for urine concentration. |
High levels mean the urine is more concentrated, which may affect test results.
Low levels mean the urine is more diluted, which can also affect the accuracy of the test. |
Total Urine Volume | Varies by age and size | Total urine volume helps make sure enough sample is collected for accurate testing and helps adjust the results for concentration. |
High levels mean the urine is more diluted, which may lower the concentration of sugars measured.
Low levels mean the urine is more concentrated, which may raise the concentration of sugars measured. |
Reference ranges may change slightly as labs update their methods and guidelines.
Leaky Gut Test | Lactulose/Mannitol | New York FAQ
Is there Leaky Gut Test | Lactulose/Mannitol | New York testing near me?
This is a home test kit that you can collect locally, and you can check the draw location link at the top of the page for more details. For people with ongoing digestive symptoms, being able to collect your sample at home makes it easier to get tested without extra travel or waiting.
How do I interpret the test results?
While your treating physician should always help you interpret your results, we also offer a one-on-one test results review with our clinical team for extra support and clear answers.
What is the cost of the test?
The price you see for the test includes standard shipping to your address and return shipping to the lab, though draw fees may apply. Ordering this test can help you find out if your gut is letting in things it shouldn’t, which can help you get relief from symptoms sooner.
How often should I retest?
Most people retest every 3 to 6 months, especially if they are making changes to their diet or treatment plan, to see if their gut barrier is improving or if more support is needed.
How accurate is the test?
This test uses a dual-sugar absorption method, measuring how much lactulose and mannitol are found in your urine after drinking the test solution. The test has a specificity of 93% and a sensitivity of 88%. TrueHealthLabs.com works with CLIA-certified and CAP-certified labs to maintain high-quality testing standards you can trust.
Important Notes
- This kit can be ordered only within the US states including New York State.
- This kit is not intended for those with kidney dysfunction.
- Do not run the test if you have allergies to Mannitol or Lactulose.
- Certain medications such as aspirin, other anti-inflammatory drugs, antacids containing aluminum or magnesium hydroxide (eg, Maalox liquid, Equate, Milk of Magnesia, Rolaids, Mylanta) as well as drugs that contain sorbitol and/or mannitol may affect your test results. Please consult with your healthcare professional know about any medications or supplements you are using before taking this test. It is recommended that you avoid the use of these medicines for at least 72 hours before taking this test.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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