DNA Methylation Pathway Profile by Mosaic Diagnostics
What is DNA Methylation?
DNA methylation is a crucial process in your body that affects how genes are expressed. It plays a significant role in various biological processes and can impact your health in multiple ways.
Methylation happens billions of times a section, acting like switches turning genes on and off to keep your body producing the right type and right amount of chemicals.
Since it takes multiple genes to get methylation right, this methylation test measures to see if there are any changes in those genes that may keep the process from working. If there are significant changes in the genes, it can lead to common health issues including:
- Insulin sensitivity (mild diabetes)
- Bone health issues
- Increased cancer risks
- Heart health
- Liver detoxification
- Fertility issues
- Mitochondrial function (our cell’s powerplant)
- Metabolism/weight issues
- Neurotransmitter balance (behavior changes, mood swings, depression, anxiety)
The good news is that using a DNA methylation test to understand the changes in these genes and can help develop treatment plans that act as a “workaround” for these genes leading to significant health improvement.
Why is This Test Important?
This test is essential for several reasons:
- Personalized Health Insights: It provides personalized genetic information on methylation, enabling you to understand where your body needs help in the methylation process.
- Preventive Health Care: Knowing specific genetic variations in the methylation pathyway can help in preventing certain health conditions.
- Targeted Lifestyle Changes: Based on your genetic makeup, you can make informed decisions about your diet, lifestyle, and supplements that can act as workarournds any genes that make it hard for your body to methylate correctly.
How Does It Work?
The test analyzes various single nucleotide polymorphisms (SNPs) in your DNA, which are slight changes in DNA and can have an impact on methylation that might be promoting health issues you may be struggling with.
Key Genes Analyzed in Your Methylation Test Order:
- VDR (Vitamin D Receptor):
- Role: Acts as the keyhole for the vitamin D you consume or get from sunlight. Helps in detoxification and impacts a third of the human genome.
- Health Impact: Affects how your body uses vitamin D, which is crucial for bone health, immune function, heart health, mood regulation, and more.
- BHMT (Betaine-Homocysteine Methyltransferase):
- Role: In the dance of methylation, there is a substance product that needs to be kept in balance, or it can wreak havoc on our bodies. This substance is called homocysteine. BHMT helps turn homocysteine into different substances that aren’t as harmful.
- Health Impact: Influences liver and kidney function and can impact cardiovascular health.
- COMT (Catechol-O-Methyltransferase):
- Role: Inactivates certain hormones and neurotransmitters.
- Health Impact: Affects mood regulation and hormone balance.
- MAO A (Monoamine Oxidase Type A):
- Role: Helps break down old neurotransmitters so they can be disposed of.
- Health Impact: Essential for mental health and detoxification processes.
- AHCY (Adenosylhomocysteinase):
- Role: Regulates methylation processes by controlling the homocysteine mentioned above.
- Health Impact: Affects cardiovascular health and energy metabolism.
- CBS (Cystathionine Beta-Synthase):
- Role: Uses vitamin B6 for crucial biochemical conversions.
- Health Impact: Impacts detoxification and antioxidant production.
- MTHFR (Methylenetetrahydrofolate Reductase):
- Role: Vital for converting forms of folate into types that the body can use more efficiently.
- Health Impact: Essential for cellular repair, DNA synthesis, and homocysteine metabolism, especially neurotransmitter formation. Proper functioning MTHFR genes are critical when pregnant since folate and its forms are important to fetal development.
- MTR/MTRR (Methionine Synthase/Reductase):
- Role: Takes that pesky homocysteine from above and makes it into proteins we can use.
- Health Impact: Affects overall cellular health, energy levels, and mental health.
- SHMT (Serine Hydroxymethyltransferase):
- Role: Involved in amino acid (building blocks of protein) conversion.
- Health Impact: Important for making DNA and DNA repair.
- SUOX (Sulfite Oxidase):
- Role: Converts sulfites to sulfates.
- Health Impact: Crucial for detoxifying toxic substances that are naturally produced from our diet. Issues here can often lead to “brain fog.”
Why Should You Order This Test?
- Actionable Information: Understand your unique methylation makeup to significantly improve your health by using specific methylation treatments that can greatly improve your health situation.
- Proactive Approach: Early identification of potential health risks can lead to preventive measures. This is especially important in family genetics.
- Tailored Recommendations: Based on your results, get personalized advice on diet, supplements, and lifestyle changes to bypass any genetic insufficiencies. Targeted methylation treatments can be very powerful in overcoming health issues.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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