Ordering the NADH/NADPH Test
NADH/NADPH testing helps measure the balance of two important molecules that support energy production in your cells. These markers are often checked for people who feel tired, have trouble focusing, or want to know more about their body’s energy systems. Interestingly, NADH and NADPH are also involved in how your body handles stress and repairs itself after physical activity.
Ordering this test can help you:
- Find out if your low energy is linked to your cell’s ability to make energy
- Check for imbalances that may affect your mood or memory
- See if your body is handling oxidative stress well
- Track changes in your energy markers over time
- Support your doctor in making decisions about fatigue, brain fog, or muscle pain
Who Should Consider Cellular Energy and Antioxidant Testing
People who feel tired even after a full night’s sleep, struggle to concentrate at work or school, or notice mood swings that seem out of place may benefit from this test. For example, someone who has tried different diets and exercise routines but still feels exhausted could use this test to check if their cells are making enough energy.
Ordering this test may also be helpful if you:
- Have ongoing muscle pain or weakness that doesn’t improve with rest
- Experience frequent brain fog or trouble remembering things
- Are recovering from a long illness and want to track your progress
- Notice changes in your mood or feel more anxious than usual
- Have a family history of mitochondrial issues, which can affect energy production in unexpected ways
Testing these markers can show if your body is making and using energy the way it should, which can help you and your doctor decide on next steps for feeling better. Waiting to order this test could mean missing early signs of energy imbalance, making it harder to address symptoms like tiredness or poor focus.
How to Prepare for the Test
Fasting is not required for the NADH/NADPH test, so you can eat and drink as usual before your sample is collected. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected the right way and your results are as helpful as possible.
Labs Included When Ordering Your NADH/NADPH Test
| Test Name | Reference Range | What the Marker Means | Low and High Levels of NADH/NADPH |
|---|---|---|---|
| NADH | 40-75 | NADH is a molecule that helps your cells turn food into energy. It is important for brain function, muscle strength, and how your body handles stress. |
High levels mean your cells may be under stress or not using energy well.
Low levels mean your body may not be making enough energy, which can lead to tiredness and trouble focusing. |
| NADPH | 30-60 | NADPH helps protect your cells from damage and supports your immune system. It also plays a role in how your body repairs itself after stress or illness. |
High levels mean your body may be fighting off stress or inflammation.
Low levels mean your cells may not be protected well, which can make it harder to recover from tiredness or illness. |
Reference ranges may change slightly if the lab updates their testing methods or guidelines.
NADH/NADPH FAQ
Is there NADH/NADPH testing near me?
This test is available as a kit that you can use at a local draw site—check the draw location link at the top of the page. For people dealing with ongoing tiredness or brain fog, having a nearby collection site makes it easier to get tested without extra travel or stress.
How do I interpret the test results?
While your doctor should review your results with you, we also offer a one-on-one test results review with our clinical team to help you understand what your numbers mean and what steps you can take next.
What is the cost of the test?
The price you see for the test includes standard shipping to your address and return shipping to the lab, but local draw fees may apply. Ordering this test can help you find out if your tiredness or trouble focusing is linked to your cell’s energy production, so you can start feeling better sooner.
How often should I retest?
It’s best to retest every 3 to 6 months, especially if you are making changes to your diet, supplements, or treatment plan. Regular testing helps track your progress and shows if your energy markers are improving or need more attention.
How accurate is the test?
This test uses high-performance liquid chromatography (HPLC) with UV detection, which is known for its precision in measuring NADH and NADPH. The test has a specificity of 98% and a sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
None.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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