Ordering the Hormones Comprehensive Plus Panel by Great Plains Labs
The Hormones Comprehensive Plus Panel by Great Plains Labs is designed to measure a wide range of hormone levels, including estrogen, progesterone, testosterone, DHEA, and cortisol throughout the day. This test helps identify patterns and imbalances that may be linked to symptoms such as fatigue, mood changes, irregular periods, and changes in metabolism. Interestingly, this panel can also reveal subtle hormone shifts that may not show up in standard blood tests, especially when symptoms are mild or fluctuate.
Ordering this test provides a clear picture of hormone activity over a full day, which is especially helpful for tracking changes related to menopause, polycystic ovary syndrome (PCOS), or hormone therapy. When ordering, you can expect these specific benefits:
- Measures estrogen, progesterone, and testosterone to help pinpoint causes of irregular periods or fertility issues
- Assesses DHEA and cortisol at four points in the day to detect adrenal fatigue or stress-related hormone changes
- Identifies hormone patterns that may contribute to weight gain, hair loss, or low libido
- Supports monitoring of hormone therapy or menopause management
- Provides detailed results for more targeted treatment planning
Who Should Consider Comprehensive Hormone Testing
People who have been feeling tired, experiencing mood swings, or noticing changes in their menstrual cycle may benefit from this test. For example, someone who has been struggling with sleep problems, sudden weight changes, and increased stress might find that hormone testing reveals a pattern that explains these symptoms.
Ordering this test may also be helpful in these situations:
- Experiencing hot flashes or night sweats during menopause
- Dealing with persistent acne that does not respond to typical treatments
- Facing unexplained hair thinning or loss
- Having trouble with fertility or irregular ovulation
- Noticing mood changes or anxiety that seem to follow a monthly pattern, which can sometimes be linked to hormone fluctuations
Testing for hormone levels can help identify the root cause of symptoms like fatigue, mood changes, or irregular cycles, making it easier to find the right treatment. Delaying this test may mean missing early signs of hormone imbalance, which could make symptoms harder to manage over time.
Preparing for a Female Hormone Panel
Fasting is not required for this saliva-based hormone test, but it is important to collect samples at the specific times listed in your kit instructions. Always follow the directions provided by your doctor or healthcare practitioner to make sure your results reflect your true hormone levels.
Labs Included When Ordering Your Hormones Comprehensive Plus Panel by Great Plains
| Test Name | Reference Range | What This Test Measures | Low and High Levels of This Marker |
|---|---|---|---|
| Estradiol | 1.3–3.3 pg/mL (saliva, premenopausal); 0.5–1.7 pg/mL (saliva, postmenopausal) | Estradiol is the main form of estrogen in women and is important for menstrual cycles, bone strength, and mood. It helps regulate ovulation and supports reproductive health. |
High levels mean possible estrogen dominance, which can cause heavy periods, weight gain, or breast tenderness.
Low levels mean possible menopause, missed periods, or bone loss. |
| Estrone | 0.6–1.8 pg/mL (saliva, premenopausal); 0.2–0.7 pg/mL (saliva, postmenopausal) | Estrone is another type of estrogen, more common after menopause. It helps balance other hormones and supports tissue health. |
High levels mean possible increased risk for estrogen-related conditions.
Low levels mean possible low estrogen symptoms like vaginal dryness or hot flashes. |
| Estriol | 0.4–1.2 pg/mL (saliva, premenopausal); 0.1–0.5 pg/mL (saliva, postmenopausal) | Estriol is a weaker estrogen, important during pregnancy and for tissue repair. It helps protect against stronger estrogen effects. |
High levels mean possible pregnancy or hormone therapy effects.
Low levels mean possible low estrogen symptoms or menopause. |
| Progesterone | 75–270 pg/mL (saliva, luteal phase); 12–100 pg/mL (saliva, follicular phase); 5–95 pg/mL (saliva, postmenopausal) | Progesterone helps prepare the uterus for pregnancy and balances the effects of estrogen. It also supports sleep and mood stability. |
High levels mean possible pregnancy or hormone therapy.
Low levels mean possible irregular periods, PMS, or trouble with pregnancy. |
| Testosterone | 16–55 pg/mL (saliva, adult women) | Testosterone is important for muscle strength, energy, and sex drive. It also helps maintain bone density and mood. |
High levels mean possible PCOS, acne, or unwanted hair growth.
Low levels mean possible low energy, low libido, or muscle weakness. |
| DHEA | 130–980 pg/mL (saliva, adult women) | DHEA is made by the adrenal glands and helps make other hormones. It supports energy, mood, and immune function. |
High levels mean possible adrenal overactivity or hormone imbalance.
Low levels mean possible adrenal fatigue or low hormone production. |
| Cortisol (4x a day) | Morning: 3.7–9.5 ng/mL; Noon: 1.2–3.0 ng/mL; Evening: 0.6–1.9 ng/mL; Night: 0.4–1.0 ng/mL | Cortisol is the main stress hormone, released in a daily pattern. It helps control energy, sleep, and the body’s response to stress. |
High levels mean possible chronic stress, sleep problems, or adrenal issues.
Low levels mean possible adrenal fatigue, low energy, or trouble handling stress. |
Reference ranges may change slightly as labs update their methods or as new research becomes available.
Hormones Comprehensive Plus Panel FAQ
Is there Hormones Comprehensive Plus Panel testing near me?
This is a home test kit that you can collect locally, and you can check the draw location link at the top of the page for more details. For people dealing with symptoms like irregular periods or fatigue, having a convenient collection option makes it easier to get tested without extra travel or waiting.
How do I interpret the test results?
While your treating physician should review your results, we also offer a one-on-one test results review with our clinical team to help you understand your hormone levels and what they mean for your symptoms.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, but draw fees may apply. Ordering this test can help you find out if hormone imbalances are causing symptoms like mood swings or fatigue, so you can start feeling better sooner.
How often should I retest?
Retesting is usually recommended every 3 to 6 months, especially if you are starting or changing hormone therapy, or if your symptoms change. Regular testing helps track how your hormone levels respond to treatment and supports more precise adjustments.
How accurate is the test?
This test uses saliva samples analyzed by advanced immunoassay methods, with a specificity of 98% and sensitivity of 97% for most hormones measured. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test can not be collected or mailed from New York State. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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