Ordering the Hemochromatosis Genetic DNA Test
Ordering the Hemochromatosis Genetic DNA Test helps find out if you have changes in your HFE gene that can cause your body to store too much iron. This test looks for three specific gene mutations—C282Y, H63D, and S65C—that are linked to hereditary hemochromatosis. Interestingly, some people with these gene changes never develop symptoms, but they can still pass the gene to their children.
When ordering this test, you get clear answers about your genetic risk for iron overload.
- Identifies if you carry or have inherited the HFE gene mutations
- Helps guide your doctor in making decisions about iron monitoring
- Supports early steps to manage iron levels if needed
- Provides information for family members who may also be at risk
- Can be done with a simple blood draw or cheek swab
Who Might Benefit from Genetic Iron Overload Screening
A person with a family history of high iron or unexplained tiredness may wonder if they are at risk for hereditary iron overload. For example, someone whose parent or sibling was diagnosed with hemochromatosis may want to know if they have the same gene changes.
Ordering this test may also be helpful in these situations:
- Someone with unexplained joint pain or liver issues
- People with abnormal iron or ferritin results on routine blood work
- Those with a family member who has tested positive for HFE gene mutations
- Anyone with early signs of diabetes or heart problems without a clear cause
- People who have bronze or gray skin coloring, which can sometimes be linked to iron overload
This test gives you specific answers about your genetic risk for iron overload, which can help you and your doctor decide if you need further checks or treatment. Delaying this test could mean missing the chance to catch iron buildup before it causes organ damage, making early detection a practical step.
Preparing for Genetic Iron Mutation Analysis
No fasting is needed before this test, and you can eat and drink as usual. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected the right way.
Labs Included When Ordering Your Hemochromatosis Genetic DNA Test
| Test Name | Reference Range | What This Test Measures | Low and High Levels of Hemochromatosis Genetic DNA Test |
|---|---|---|---|
| Hemochromatosis DNA Analysis (C282Y, H63D, S65C mutations in HFE gene) | No mutations detected | This test checks for three specific changes in the HFE gene that can cause your body to absorb too much iron. It helps find out if you are at risk for hereditary hemochromatosis or if you are a carrier. |
High levels mean you have one or more HFE gene mutations, which can increase your risk for iron overload.
Low levels mean no HFE gene mutations were found, so your risk for hereditary iron overload is low. |
Lab reference values are subject to change. Refer to the Quest Diagnostics lab test directory for current ranges.
Hemochromatosis Genetic DNA Test FAQ
Is there Hemochromatosis Genetic DNA testing near me?
You can find nearby locations for Hemochromatosis Genetic DNA testing using the patient service center locator, which also lists mobile phlebotomy options. Since this test may require a blood draw or cheek swab, having a convenient site makes sample collection easier, especially if you need regular monitoring.
What is the cost of the test?
The price you see for the Hemochromatosis Genetic DNA Test includes all fees, including sample collection at patient service center locations. Ordering this test is worth it if you want clear answers about your genetic risk for iron overload, especially if you have a family history.
How often should I retest?
Most people only need to take this genetic test once, since your DNA does not change over time. Retesting is only needed if your doctor requests a confirmation or if new gene mutations are added to the test in the future.
How accurate is the test?
This test uses polymerase chain reaction (PCR) and DNA sequencing to detect HFE gene mutations, with a specificity and sensitivity of over 99%. All tests at TrueHealthLabs.com are performed by CLIA-certified labs, meeting strict quality and precision standards.
Important Notes
None.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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