Ordering the DUTCH Complete Test | Precision Analytical | International
The DUTCH Complete Test by Precision Analytical provides a detailed look at hormone production and metabolism, including estrogen, progesterone, testosterone, DHEA, cortisol, and melatonin. This test also checks for organic acids, which can show nutritional gaps, oxidative stress, and gut imbalances. Interestingly, the DUTCH Complete Test uses dried urine samples, which allow for a more complete picture of hormone patterns throughout the day compared to single blood or saliva samples.
Ordering this test can help you track hormone changes, spot imbalances, and guide treatment plans. Here are some specific benefits of ordering the DUTCH Complete Test:
- Shows how your body makes and breaks down estrogen, progesterone, and testosterone.
- Reveals patterns in cortisol and melatonin that can affect sleep and stress.
- Identifies markers for oxidative stress and nutritional deficiencies.
- Highlights possible gut issues through organic acid markers.
- Helps guide hormone therapy or other treatments with clear, actionable data.
Who Should Consider Hormone and Adrenal Testing
People who feel tired even after a full night’s sleep, struggle with mood swings, or notice changes in weight or energy may benefit from this test. For example, someone who has tried different diets and exercise routines but still feels exhausted and moody could use this test to find out if hormone imbalances are part of the problem.
Ordering this test may also be helpful in these situations:
- Experiencing trouble falling or staying asleep, even with good sleep habits.
- Dealing with irregular periods, hot flashes, or other signs of menopause or PMS.
- Facing ongoing stress that doesn’t improve with rest or relaxation techniques.
- Trying to get pregnant without success, despite normal basic fertility tests.
- Noticing changes in memory or focus that seem linked to hormone shifts, which is less commonly connected to hormone testing but can be revealing.
Testing can help pinpoint hormone patterns that may be causing symptoms like fatigue, mood changes, or sleep problems. Delaying this test could mean missing the chance to address hormone imbalances early, which may make symptoms harder to manage over time.
How to Prepare for the Test
Fasting is not required for the DUTCH Complete Test, but you should avoid collecting samples during menstruation for the most accurate results. Always follow any instructions your doctor or healthcare provider gives you, as they may have specific guidance based on your situation.
Labs Included When Ordering Your DUTCH Complete Test | Precision Analytical | International
| Test Name | Reference Range | What This Test Shows | Low and High Levels of DUTCH Complete Test |
|---|---|---|---|
| Sex Hormones & Metabolites | |||
| Estrone (E1) | 6-32 | Estrone is a type of estrogen important for reproductive health and bone strength. It is one of the main estrogens measured in hormone testing. |
High levels mean possible estrogen dominance, increased risk for certain cancers, or hormone therapy effects.
Low levels mean possible menopause, ovarian issues, or low estrogen production. |
| Estradiol (E2) | 1-7 | Estradiol is the most active form of estrogen, affecting mood, menstrual cycles, and bone health. It is key for both women and men. |
High levels mean possible ovarian cysts, hormone therapy, or estrogen-producing tumors.
Low levels mean menopause, low ovarian function, or pituitary issues. |
| Estriol (E3) | 0-7 | Estriol is a weaker estrogen, mostly present during pregnancy, but also helps balance other estrogens in the body. |
High levels mean pregnancy or increased estrogen metabolism.
Low levels mean low estrogen production or non-pregnant state. |
| 2-OHE1 | 0.5-5.0 | This is a metabolite of estrone, showing how your body breaks down estrogen. It is linked to lower risk of estrogen-related cancers. |
High levels mean increased estrogen breakdown through a protective pathway.
Low levels mean less protective estrogen metabolism. |
| 4-OHE1 | 0.1-0.8 | This metabolite can be harmful if not cleared well, as it may damage DNA and increase cancer risk. |
High levels mean higher risk for DNA damage and estrogen-related cancers.
Low levels mean less risk from this pathway. |
| 16-OHE1 | 0.5-5.0 | This estrogen metabolite is linked to tissue growth and may play a role in hormone-related conditions. |
High levels mean increased risk for hormone-driven tissue growth or cancer.
Low levels mean less tissue stimulation from estrogen. |
| 2-MeOE1 | 0.1-1.0 | This is a methylated estrogen metabolite, showing how well your body detoxifies estrogen. It is considered protective. |
High levels mean good estrogen detoxification.
Low levels mean less protective methylation of estrogen. |
| 2-OHE2 | 0.1-1.0 | This is a breakdown product of estradiol, showing how your body processes estrogen. It is linked to lower cancer risk. |
High levels mean increased protective estrogen metabolism.
Low levels mean less breakdown through this pathway. |
| 4-OHE2 | 0.01-0.2 | This metabolite can be harmful if not cleared, as it may damage DNA. It is important to keep this in balance. |
High levels mean higher risk for DNA damage and hormone-related cancers.
Low levels mean less risk from this pathway. |
| Testosterone | 20-80 | Testosterone is a key hormone for muscle strength, mood, and sex drive in both men and women. |
High levels mean possible PCOS, adrenal issues, or testosterone therapy.
Low levels mean fatigue, low sex drive, or muscle loss. |
| Dihydrotestosterone (DHT) | 2-10 | DHT is a potent form of testosterone, important for hair growth and prostate health. |
High levels mean risk for hair loss or prostate issues.
Low levels mean possible low sex drive or muscle weakness. |
| DHEA-S | 1000-4000 | DHEA-S is a hormone made by the adrenal glands, supporting energy, mood, and hormone balance. |
High levels mean adrenal overactivity or supplementation.
Low levels mean adrenal fatigue or aging. |
| Progesterone | 200-3000 | Progesterone helps regulate menstrual cycles, supports pregnancy, and balances the effects of estrogen. |
High levels mean pregnancy or hormone therapy.
Low levels mean irregular cycles, PMS, or fertility issues. |
| Adrenal Hormones & Metabolites | |||
| Cortisol | 20-50 (morning), 5-25 (night) | Cortisol is the main stress hormone, affecting energy, sleep, and immune function. It follows a daily rhythm. |
High levels mean chronic stress, adrenal overactivity, or sleep problems.
Low levels mean adrenal fatigue or low stress response. |
| Melatonin & Sleep Markers | |||
| Melatonin (6-OHMS) | 10-60 | Melatonin is the main sleep hormone, helping you fall asleep and stay asleep. 6-OHMS is its main metabolite in urine. |
High levels mean possible overproduction or supplementation.
Low levels mean sleep problems or low melatonin production. |
| Oxidative Stress & Nutritional Markers | |||
| 8-OHdG | 2-10 | 8-OHdG is a marker for oxidative stress and DNA damage, showing how much stress your cells are under. |
High levels mean increased oxidative stress or DNA damage.
Low levels mean low oxidative stress. |
| Organic Acids (OATs) | |||
| Vanilmandelate (VMA) | 1-7 | VMA is a breakdown product of adrenaline and noradrenaline, showing how your body handles stress hormones. |
High levels mean increased stress or adrenal activity.
Low levels mean low stress hormone production. |
| Homovanillate (HVA) | 2-8 | HVA is a dopamine metabolite, showing how your body processes this important brain chemical for mood and focus. |
High levels mean increased dopamine breakdown or stress.
Low levels mean low dopamine activity. |
| Kynurenate | 2-12 | Kynurenate is a tryptophan metabolite, linked to brain health and inflammation. It can affect mood and sleep. |
High levels mean increased inflammation or tryptophan breakdown.
Low levels mean low tryptophan metabolism. |
| Methylmalonate | 0.5-3.5 | Methylmalonate is a marker for vitamin B12 status. High levels can mean a B12 deficiency. |
High levels mean possible vitamin B12 deficiency.
Low levels mean normal B12 status. |
| Xanthurenate | 0.5-3.0 | Xanthurenate is a marker for vitamin B6 status and tryptophan metabolism. It can affect mood and energy. |
High levels mean possible vitamin B6 deficiency.
Low levels mean normal B6 status. |
| Pyroglutamate | 10-40 | Pyroglutamate is linked to glutathione status, an important antioxidant in the body. It helps protect cells from damage. |
High levels mean possible glutathione deficiency or oxidative stress.
Low levels mean normal antioxidant status. |
| Quinolinate | 0.5-3.0 | Quinolinate is a marker for inflammation and brain health, coming from tryptophan metabolism. |
High levels mean increased inflammation or neurotoxicity.
Low levels mean low inflammation. |
| Indican | 0-10 | Indican is a marker for gut bacteria imbalance, showing how well your body digests protein. |
High levels mean possible gut dysbiosis or poor protein digestion.
Low levels mean normal gut bacteria balance. |
| b-Hydroxyisovalerate | 0.5-2.0 | This marker shows how your body breaks down the amino acid leucine, and can point to biotin status. |
High levels mean possible biotin deficiency.
Low levels mean normal biotin status. |
Reference ranges may change slightly as labs update their methods and guidelines.
DUTCH Complete Test | Precision Analytical | International FAQ
Is there DUTCH Complete Test | Precision Analytical | International testing near me?
This is a home test kit, so you can collect your samples locally without needing to visit a lab; check the draw location link at the top of the page for more details. For people dealing with hormone-related fatigue or sleep issues, being able to collect samples at home makes it easier to get tested without extra travel or stress.
How do I interpret the test results?
While your treating physician should review your results, we also offer a one-on-one test results review with our clinical team to help you understand your results and next steps.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, but draw fees may apply. Ordering this test can help you address hormone imbalances sooner, which may help you feel better faster.
How often should I retest?
Retesting is usually recommended every 3-6 months, especially if you are starting or changing hormone therapy, to track progress and adjust your plan as needed.
How accurate is the test?
The DUTCH Complete Test uses dried urine collection and advanced mass spectrometry for hormone and metabolite analysis, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test is available in Europe and other international countries. Contact us with questions.
- You will be responsible for the shipping costs.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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