Ordering the Celiac Profile | Genova
The Celiac Profile from Genova Diagnostics helps identify gluten-related immune responses by measuring specific antibodies in the blood. This test is often ordered to help clarify the cause of symptoms like digestive discomfort, fatigue, or unexplained nutrient deficiencies. Interestingly, some people with celiac disease may not have obvious digestive symptoms but still experience issues like joint pain or skin rashes.
Ordering this test can provide:
- Detection of both common and less common immune responses to gluten
- Assessment of total IgA to rule out IgA deficiency, which can affect test results
- Identification of possible wheat allergy or gluten sensitivity
- Support for diagnosis in people with non-digestive symptoms
- Guidance for dietary changes and follow-up care
Who Should Consider Gluten Sensitivity and Autoimmune Screening
People who have ongoing digestive issues, unexplained fatigue, or skin rashes may benefit from this test. For example, someone who has tried removing gluten from their diet but still feels tired and has frequent headaches might find answers through this testing.
Ordering may also be helpful in these situations:
- Someone with a family history of celiac disease or autoimmune disorders
- People with unexplained anemia or vitamin deficiencies
- Those experiencing infertility without a clear cause
- Children with slow growth or delayed puberty
- Adults with osteoporosis that does not improve with standard treatment
This test can help pinpoint the cause of symptoms by measuring specific antibodies, which can lead to targeted treatment and prevent long-term complications. Delaying this test may result in ongoing symptoms and missed opportunities for early intervention.
Preparing for Gluten Antibody and Autoimmunity Testing
Fasting is required for this test; do not eat or drink anything except water for at least 8 hours before your blood draw. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Celiac Profile | Genova
| Test Name | Reference Range | What This Biomarker Means | Low and High Levels of Celiac Profile | Genova |
|---|---|---|---|
| Anti-Deamidated Gliadin IgA | <20 | This antibody targets gliadin, a protein in gluten. It helps detect immune reactions linked to celiac disease, especially in people with active symptoms. |
High levels mean the immune system is reacting to gluten, which may suggest celiac disease or gluten sensitivity.
Low levels mean there is little or no immune response to gliadin. |
| Anti-Deamidated Gliadin IgG | <20 | This marker checks for IgG antibodies against gliadin, useful for people with IgA deficiency or those with non-classic celiac symptoms. |
High levels mean there may be an immune response to gluten, even if IgA is normal or low.
Low levels mean there is little or no IgG response to gliadin. |
| Anti-Tissue Transglutaminase IgA | <20 | This antibody is highly specific for celiac disease and is often the first test used to screen for it. It measures the immune response to tissue transglutaminase, an enzyme involved in gluten processing. |
High levels mean a strong likelihood of celiac disease.
Low levels mean celiac disease is less likely, but not ruled out. |
| Anti-Tissue Transglutaminase IgG | <20 | This test is helpful for people who cannot make enough IgA. It checks for IgG antibodies against tissue transglutaminase, supporting diagnosis in special cases. |
High levels mean possible celiac disease, especially in those with IgA deficiency.
Low levels mean a low chance of celiac disease in this context. |
| EMA IgA (reflex only) | Negative | Endomysial antibody IgA is a confirmatory test for celiac disease. It is usually done if other markers are positive, adding extra confidence to the diagnosis. |
High levels mean a strong confirmation of celiac disease.
Low levels mean celiac disease is less likely. |
| Total IgA | 70-400 | Total IgA checks for overall IgA antibody levels. This helps make sure other IgA-based tests are valid and not falsely low due to IgA deficiency. |
High levels mean possible immune system activation or inflammation.
Low levels mean IgA deficiency, which can affect the accuracy of other antibody tests. |
Reference ranges may change slightly as labs update their methods and guidelines.
Celiac Profile | Genova FAQ
Is there Celiac Profile | Genova testing near me?
This is a test kit that can be collected at a local draw site; check the draw location link at the top of the page. For people experiencing ongoing digestive symptoms or unexplained fatigue, having a nearby collection site makes it easier to get tested without added stress or travel.
How do I interpret the test results?
While your treating physician should review your results, we also offer a one-on-one test results review with our clinical team to help you understand what your results mean and what steps to take next.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, but draw fees may apply. Ordering this test can help you find out if gluten is causing your symptoms, so you can start feeling better sooner.
How often should I retest?
Retesting is usually recommended 6-12 months after starting a gluten-free diet or treatment plan to check for changes in antibody levels. This helps track your progress and see if your immune response to gluten is improving.
How accurate is the test?
This test uses enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence methods, with a specificity of 95-98% and sensitivity of 90-98% for celiac disease markers. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test kit cannot be mailed or collected in New York State. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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