Ordering the Intestinal Permeability Test (Leaky Gut Test) | Cyrex Array #2
The Intestinal Permeability Test from Cyrex Labs helps identify if the lining of your digestive tract is letting unwanted particles pass into your bloodstream. This can be linked to symptoms like bloating, fatigue, joint pain, and skin issues. Interestingly, this test can also show if your gut lining is reacting to gluten or other food proteins, which is not always obvious from symptoms alone.
Ordering this test gives you a clear picture of your gut barrier function and helps your healthcare provider target the right support. Here are some specific benefits of ordering:
- Pinpoints if your gut lining is breaking down or if cell junctions are loose
- Shows if your immune system is reacting to gut bacteria or food proteins
- Helps track progress if you are already working on gut repair
- Guides your provider in choosing the best plan for gut support
- Can reveal hidden triggers for symptoms like brain fog or skin rashes
Who Should Consider Gut Barrier and Digestive Tract Testing
People who have tried many diets or supplements but still deal with ongoing digestive problems, fatigue, or unexplained symptoms may benefit from this test. For example, someone who has cut out gluten and dairy but still feels tired and bloated could use this test to see if their gut lining is still letting unwanted particles through.
Ordering may also be helpful in these situations:
- Long-term bloating or stomach pain that does not improve with common treatments
- Unexplained joint pain or muscle aches that come and go
- Skin problems like eczema or rashes that flare up after eating certain foods
- Brain fog or trouble focusing that seems linked to meals
- People with a family history of autoimmune conditions, as gut permeability can play a role in these issues
This test can help you and your provider find out if your gut lining is letting in things that should stay out, which can lead to immune reactions and inflammation. Waiting to order may mean missing the chance to catch early changes in your gut barrier, which could make symptoms harder to manage later. Take the next step to get clear answers about your gut.
How to Prepare for Digestive Wellness and Immune System Testing
Fasting is not required for this test, but you should review the kit instructions for any special steps before your blood draw. Always follow the directions your doctor or healthcare provider gives you to make sure your sample is collected the right way and your results are as helpful as possible.
Labs Included When Ordering Your Intestinal Permeability Test (Leaky Gut Test) | Cyrex Array #2
| Test Name | Reference Range | What This Marker Means | Low and High Levels of Intestinal Permeability Test |
|---|---|---|---|
| Actomyosin IgG | 0-19 | This marker checks for immune reactions to actomyosin, a protein found in the gut lining. It can show if your immune system is attacking your own gut tissue. |
High levels mean your immune system may be reacting to damage in your gut lining.
Low levels mean there is little or no immune response to this gut protein. |
| Occludin / Zonulin IgG | 0-19 | This marker measures immune response to occludin and zonulin, proteins that help keep gut cells tightly joined. It helps show if the gut barrier is becoming loose. |
High levels mean your immune system is reacting to proteins that control gut cell tightness, which may signal a leaky gut.
Low levels mean there is little or no immune response to these proteins. |
| Occludin / Zonulin IgA | 0-19 | This marker checks for IgA antibodies to occludin and zonulin, showing if your gut’s immune system is reacting to these barrier proteins. |
High levels mean your gut’s immune system is responding to barrier breakdown.
Low levels mean there is little or no immune response in the gut to these proteins. |
| Occludin / Zonulin IgM | 0-19 | This marker looks for early immune response (IgM) to occludin and zonulin, which can show recent or ongoing gut barrier changes. |
High levels mean there may be a new or active problem with gut barrier proteins.
Low levels mean there is little or no recent immune response to these proteins. |
| Lipopolysaccharides (LPS) IgG | 0-19 | This marker checks for immune response to LPS, a toxin from gut bacteria. It can show if bacteria or their toxins are leaking into the bloodstream. |
High levels mean your immune system is reacting to bacterial toxins that have crossed the gut barrier.
Low levels mean there is little or no immune response to these bacterial toxins. |
| Lipopolysaccharides (LPS) IgA | 0-19 | This marker measures gut immune response (IgA) to LPS, showing if your gut’s defense system is reacting to bacterial toxins. |
High levels mean your gut’s immune system is responding to bacterial toxins in the gut.
Low levels mean there is little or no gut immune response to these toxins. |
| Lipopolysaccharides (LPS) IgM | 0-19 | This marker looks for early immune response (IgM) to LPS, which can show recent or ongoing exposure to bacterial toxins from the gut. |
High levels mean there may be a new or active leak of bacterial toxins into the bloodstream.
Low levels mean there is little or no recent immune response to these toxins. |
Reference ranges may change slightly as labs update their methods or as new research becomes available. Always review your results with your provider for the most up-to-date information.
Intestinal Permeability Test (Leaky Gut Test) FAQ
Is there Intestinal Permeability Test (Leaky Gut Test) testing near me?
This is a test kit that you can take to a local blood draw site—check the draw location link at the top of the page. For people with ongoing digestive symptoms, having a nearby collection site makes it easier to get tested quickly and start finding answers.
How do I interpret the test results?
While your treating physician should always help you interpret your results, we also offer a one-on-one test results review with our clinical team to help you understand what your results mean and what steps to take next.
What is the cost of the test?
The price you see includes standard shipping to you and back to the lab, but blood draw fees may apply at your chosen collection site. Ordering this test can help you find out if your gut lining is letting in things that trigger symptoms, so you can start targeted support sooner.
How often should I retest?
Retesting is usually recommended every 3-6 months if you are working on gut repair or making changes to your diet or supplements. This helps track your progress and shows if your gut barrier is improving or if more support is needed.
How accurate is the test?
This test uses ELISA (enzyme-linked immunosorbent assay) to measure specific antibodies, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- It is recommended to be clear of immunosuppressants and/or corticosteroids for at least 60 days prior to taking this test. Please consult with your prescribing healthcare provider.
- NOT AVAILABLE IN NEW YORK. SPECIMEN DRAWS CAN BE COMPLETED IN NEIGHBORING STATES.
- We are now accepting international orders. Sample must be received within 7 days. Additional return shipping fees may apply.
- READ: IMPORTANT Cyrex FAQs
- Due to circumstances beyond our control, pediatric blood draws are not included under Cyrex’s contracted phlebotomy. All patients 15 years of age and younger are included in the pediatric group. Pediatric blood draws must be scheduled by the parents at a laboratory of their choosing, and must be paid for by the parent at the time of service.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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