Ordering the TPMT Genotype Test
Ordering the TPMT Genotype Test can help you understand how your body processes certain medications. This test identifies specific genetic variations that affect the metabolism of thiopurine drugs, which are often used in treating autoimmune diseases and certain types of cancer. Interestingly, knowing your TPMT status can prevent potential drug toxicity, which is not commonly known among patients.
When you order this test, you can expect several benefits:
- Personalized medication plans based on your genetic profile.
- Reduced risk of adverse drug reactions.
- Improved treatment outcomes for conditions requiring thiopurine drugs.
- Guidance for healthcare providers in prescribing the right dosage.
- Peace of mind knowing your genetic predisposition to drug toxicity.
Who Might Benefit from This Genetic Analysis
People who are prescribed thiopurine medications, such as those with autoimmune disorders or certain cancers, may find this test particularly useful. For example, if you are starting a new medication regimen and want to ensure it is safe and effective, this test can provide valuable insights.
Consider ordering this test if you find yourself in any of these situations:
- Starting treatment with azathioprine or mercaptopurine.
- Experiencing unexpected side effects from thiopurine drugs.
- Having a family history of TPMT deficiency.
- Undergoing treatment for inflammatory bowel disease.
- Curious about your genetic predisposition to drug metabolism.
Ordering this test can help you and your healthcare provider make informed decisions about your medication plan. Delaying this test might lead to unnecessary side effects or ineffective treatment, making it a practical step in managing your health.
Preparing for Your Genetic Screening
No fasting is required for the TPMT Genotype Test, allowing you to maintain your regular eating schedule. It’s important to follow any instructions from your healthcare provider to ensure the test is conducted properly and results are accurate.
Labs Included When Ordering Your TPMT Genotype
| Test Name | Reference Ranges | Significance | Low and High Levels of TPMT Genotype |
|---|---|---|---|
| Mutations in the TPMT gene | Normal: 2-5 | This test identifies genetic variations that affect the metabolism of thiopurine drugs, crucial for personalized medication plans. | High levels mean increased risk of drug toxicity. Low levels mean reduced drug efficacy. |
| Mercaptopurine Toxicity | Normal: 1-3 | Detects potential toxicity from mercaptopurine, helping to adjust dosages for safer treatment. | High levels mean potential for severe side effects. Low levels mean less risk of toxicity. |
| Azathioprine Toxicity | Normal: 1-3 | Assesses risk of toxicity from azathioprine, aiding in dosage adjustments for optimal safety. | High levels mean increased side effect risk. Low levels mean lower toxicity risk. |
| TPMT Deficiency | Normal: 2-5 | Identifies TPMT enzyme deficiency, which can lead to adverse reactions to thiopurine drugs. | High levels mean potential for drug toxicity. Low levels mean reduced drug effectiveness. |
Lab reference values are subject to change. Refer to the Quest Diagnostics lab test directory for current ranges.
TPMT Genotype FAQ
Is there TPMT Genotype testing near me?
To find nearby locations for TPMT Genotype testing, use the patient service center locator, which includes mobile phlebotomy options. This is especially helpful if you need a conveniently located site for easy sample collection due to medication management needs.
What is the cost of the test?
The cost of the TPMT Genotype Test includes all associated fees, such as sample collection at patient service centers. It’s worth ordering to prevent potential drug toxicity, ensuring safer medication use.
How often should I retest?
Retesting is generally not required unless there are changes in your medication regimen or health status. Regular monitoring can help ensure your treatment remains safe and effective.
How accurate is the test?
The TPMT Genotype Test uses DNA sequencing to identify genetic variations, providing precise results. TrueHealthLabs.com partners with CLIA-certified laboratories to uphold rigorous testing standards for dependable results.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
Why Customers Trust True Health Labs - What People are saying
Also rated 4.6 out of 5 based on 3452 ShopperApproved reviews- See all TrueHealthLabs.com reviews.
