Ordering the Rickettsia rickettsii and felis/typhi PCR
This test helps detect the DNA of Rickettsia rickettsii, Rickettsia felis, and Rickettsia typhi, which are bacteria linked to tick-borne and flea-borne diseases. It is often used when symptoms like fever, headache, muscle pain, or rash appear after a tick or flea bite. Interestingly, PCR testing can find these bacteria even before the body makes antibodies, which can help with early detection.
Ordering this test can help you and your doctor:
- Identify the specific type of Rickettsia infection quickly
- Start the right treatment sooner
- Reduce the risk of complications from delayed diagnosis
- Rule out other causes of similar symptoms
- Track the progress of an infection if you have ongoing symptoms
Who Should Consider Rickettsial PCR and Related Tick-Borne Disease Testing
People who have recently spent time in wooded or grassy areas and develop sudden fever, headache, or a spotted rash may benefit from this test. For example, someone who enjoys hiking and notices a tick bite followed by flu-like symptoms could use this test to find out if a Rickettsia infection is present.
Ordering this test may also be helpful in these situations:
- After a known tick or flea bite with new symptoms
- When symptoms like muscle pain, chills, or confusion appear after outdoor activities
- If you have a rash that does not improve with usual care
- When other tick-borne diseases like Lyme or ehrlichiosis are suspected
- For people with unexplained eye redness and fever after travel to areas where Rickettsia is common
Testing can help confirm the cause of symptoms and guide the right treatment, which may prevent the infection from spreading or causing more serious problems. Delaying this test could mean missing the best window for early treatment, which can make recovery take longer.
Preparing for Rickettsia and Typhus PCR Screening
Fasting is not needed for this test, so you can eat and drink as usual before your sample is collected. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected the right way and your results are as helpful as possible.
Labs Included When Ordering Your Rickettsia rickettsii and felis/typhi PCR
| Test Name | Reference Range | Significance | Low and High Levels of Rickettsia rickettsii and felis/typhi PCR |
|---|---|---|---|
| Rickettsia rickettsii DNA (PCR) | Not detected | This test looks for the genetic material of Rickettsia rickettsii, the bacteria that causes Rocky Mountain spotted fever. Early detection helps guide treatment and prevent complications. |
High levels mean the bacteria is present and an active infection is likely.
Low levels mean the bacteria was not found, making an active infection less likely. |
| Rickettsia felis DNA (PCR) | Not detected | This test checks for Rickettsia felis, a bacteria spread by fleas that can cause fever and rash. It helps identify less common rickettsial infections. |
High levels mean an active Rickettsia felis infection is present.
Low levels mean no evidence of Rickettsia felis infection was found. |
| Rickettsia typhi DNA (PCR) | Not detected | This test finds Rickettsia typhi, the cause of murine typhus, which can lead to fever, headache, and rash. It helps confirm or rule out typhus in people with symptoms. |
High levels mean an active Rickettsia typhi infection is present.
Low levels mean no Rickettsia typhi DNA was found in the sample. |
Reference ranges may change slightly as labs update their methods and standards.
Rickettsia rickettsii and felis/typhi PCR FAQ
Is there Rickettsia rickettsii and felis/typhi PCR testing near me?
This is a test kit that you can use locally, and you can check the draw location link at the top of the page for details. Since symptoms like fever and rash can appear quickly after a tick or flea bite, having a nearby collection site makes it easier to get tested without delay.
How do I interpret the test results?
While your treating physician should always review your results, you can also use our one-on-one test results review service with our clinical team for extra support and clear explanations.
What is the cost of the test?
The price you see for this test includes standard shipping to you and back to the lab, but draw fees may apply. Ordering this test can help you find out if a Rickettsia infection is causing your symptoms, which can help you get the right treatment sooner.
How often should I retest?
Retesting is usually only needed if symptoms return or if your doctor recommends it based on your situation. Repeating the test can help confirm if the infection has cleared or if further treatment is needed.
How accurate is the test?
This test uses polymerase chain reaction (PCR) to detect the DNA of Rickettsia bacteria, with a sensitivity of 95% and specificity of 98%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
Note: Only R. rickettsii will be reported for residents of New York
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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