Ordering the Rickettsia rickettsii and felis/typhi PCR Whole Blood | New York
This test helps detect DNA from Rickettsia rickettsii, Rickettsia felis, and Rickettsia typhi in whole blood, which can help identify infections like Rocky Mountain spotted fever and typhus. Early detection can help guide treatment and prevent complications from these vector-borne diseases. Interestingly, Rickettsia felis is often linked to flea-borne spotted fever, which is less commonly recognized than tick-borne infections.
Ordering this test can provide:
- Direct detection of Rickettsia DNA for faster diagnosis
- Ability to distinguish between different Rickettsia species
- Support for targeted treatment decisions
- Useful information for people with unexplained fever and rash after a tick or flea bite
- Results that can help avoid unnecessary antibiotics if the infection is not present
Who Should Consider Rickettsial PCR Blood Testing
People who have recently spent time in wooded or grassy areas and later develop fever, headache, or a rash may benefit from this test. For example, someone who enjoys hiking and later notices a rash and swollen lymph nodes after a tick bite may want to check for Rickettsia infection.
Ordering may also be helpful in these situations:
- After a flea bite followed by sudden fever and muscle pain
- When a person has traveled to an area with known outbreaks of spotted fever or typhus
- For those with unexplained joint pain and fatigue after outdoor activities
- Following a tick bite in regions where Rickettsia is common
- When a person has a history of exposure to animals that may carry fleas or ticks, even if symptoms are mild
Testing can help confirm or rule out infection, which can lead to more precise treatment and avoid delays that might allow symptoms to worsen or complications to develop. Waiting to order this test could mean missing the best window for early detection, which may affect how quickly symptoms improve.
Preparing for Rickettsial DNA Detection in Blood
Fasting is not required before this test, so you can eat and drink as usual. Always follow any specific instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Rickettsia rickettsii and felis/typhi PCR Whole Blood
| Test Name | Reference Range | What the Test Measures | Low and High Levels of Rickettsia rickettsii and felis/typhi PCR Whole Blood |
|---|---|---|---|
| Rickettsia rickettsii DNA (PCR) | Not detected | This test looks for the genetic material of Rickettsia rickettsii, the bacteria that causes Rocky Mountain spotted fever. It helps confirm if the infection is present in the blood. |
High levels mean the bacteria is present, which may indicate an active infection.
Low levels mean the bacteria was not found, suggesting no current infection. |
| Rickettsia felis/typhi DNA (PCR) | Not detected | This test checks for the DNA of Rickettsia felis and Rickettsia typhi, which can cause flea-borne spotted fever and murine typhus. It helps identify these infections early. |
High levels mean one of these bacteria is present, which may point to an active infection.
Low levels mean the bacteria was not found, so infection is unlikely. |
Reference ranges may change slightly as labs update their methods and guidelines.
Rickettsia rickettsii and felis/typhi PCR Whole Blood FAQ
Is there Rickettsia rickettsii and felis/typhi PCR Whole Blood testing near me?
This is a test kit that you can use with a local blood draw site—check the draw location link at the top of the page. Because symptoms like fever and rash can appear quickly after a tick or flea bite, having a nearby collection option makes it easier to get tested without delay.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation.
What is the cost of the test?
The price you see includes standard shipping to you and return shipping to the lab, but local draw fees may apply. Ordering this test can help you get answers about possible Rickettsia infection sooner, which may help you start the right treatment faster.
How often should I retest?
Retesting is usually only needed if symptoms return or if your doctor recommends it based on your exposure risk or ongoing symptoms. Repeating the test can help confirm if treatment has worked or if a new infection has occurred.
How accurate is the test?
This test uses polymerase chain reaction (PCR) to detect Rickettsia DNA, with a sensitivity of about 95% and specificity of 98%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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