Organic Acids (OAT) Test by Great Plains Labs (Now MosaicDx)
The Organic Acids Test (OAT) provides information about the body’s biochemical balance by measuring metabolic byproducts in urine. The 76 biproducts, including creatinine, can indicate vitamin and hormone metabolism, energy cycle function, intestinal wall integrity, neurotransmitter metabolites, and intestinal infections like fungus and bacteria.
It also includes markers for vitamin and mineral levels, oxidative stress, and is the only OAT to include markers for oxalates, which are highly correlated with kidney stones. Some of the markers below can be an indirect indicator for infections and if positive, should be followed up with more direct testing.
Organic Acids Test Bio Marker Summary
| Bio Marker | Description |
|---|---|
| Main: Intestinal Microbial Overgrowth | |
| Sub: Yeast and Fungal Markers | |
| Citramalic | Indicates overgrowth of yeast or fungi in the gut. |
| 5-Hydroxymethyl-2-furoic | Associated with Aspergillus and yeast byproducts. |
| 3-Oxoglutaric | Signals the presence of Aspergillus in the gut. |
| Furan-2,5-dicarboxylic | Byproduct of fungal activity, particularly Aspergillus. |
| Furancarbonylglycine | Reflects overgrowth of Aspergillus species. |
| Tartaric | Marker of Candida or other yeast species in the gut. |
| Arabinose | Indicator of Candida yeast overgrowth. |
| Carboxycitric | Linked to Fusarium mold exposure or growth. |
| Tricarballylic | Associated with dietary mold or fungal growth. |
| Main: Bacterial Markers | |
| Hippuric | Represents bacterial metabolism or gut flora imbalance. |
| 2-Hydroxyphenylacetic | Indicates bacterial fermentation in the gut. |
| 4-Hydroxybenzoic | Marker for bacterial overgrowth and imbalance. |
| 4-Hydroxyhippuric | Reflects activity of beneficial or harmful gut bacteria. |
| DHPPA (Beneficial Bacteria) | Indicates activity of health-promoting gut bacteria. |
| Main: Clostridia Bacterial Markers | |
| 4-Hydroxyphenylacetic | Associated with Clostridia bacterial metabolism. |
| HPHPA | Byproduct of Clostridia species like C. sporogenes. |
| 4-Cresol | Linked to Clostridia difficile and other strains. |
| 3-Indoleacetic | Reflects bacterial tryptophan metabolism. |
| Main: Oxalate Metabolites | |
| Glyceric | Indicates metabolism of oxalate precursors in the body. |
| Glycolic | Represents pathways leading to oxalate production. |
| Oxalic | Linked to oxalate levels in the body, associated with kidney stones. |
See the example OAT report for the comprehensive list of markers in this test.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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