Ordering the Methylation Panel | Genova | Canada
The Methylation Panel by Genova Diagnostics helps identify imbalances in the methylation pathway, which can affect how the body processes nutrients, manages stress, and supports brain function. This test measures both genetic markers and key metabolites, providing a detailed look at how well the body is using nutrients like folate and vitamin B12. Interestingly, methylation also plays a role in how the body detoxifies chemicals and supports DNA repair, which is not widely known.
Ordering this test can help you:
- Pinpoint nutrient deficiencies that may be affecting energy and mood
- Identify genetic variations that impact how your body uses B vitamins
- Detect imbalances linked to memory loss, brain fog, and trouble concentrating
- Assess risk factors for cardiovascular issues related to homocysteine levels
- Support targeted nutrition and supplement plans for better metabolic function
Who Should Consider a Methylation Pathway Assessment
People who feel tired even after a full night’s sleep, struggle with mood swings, or notice changes in memory and focus may benefit from this test. For example, someone who has tried different diets and supplements but still feels fatigued and irritable could use this test to find out if methylation imbalances are part of the problem.
Ordering may also be helpful in these situations:
- Frequent feelings of stress or anxiety that don’t improve with lifestyle changes
- Unexplained weight gain despite regular exercise and healthy eating
- Family history of heart disease or early cognitive decline
- Difficulty recovering from illness or frequent infections
- People who have trouble detoxifying after chemical exposures, such as sensitivity to cleaning products or perfumes
Testing for methylation imbalances can reveal specific nutrient needs, help guide supplement choices, and provide measurable data on metabolic function. Delaying this test may mean missing early signs of nutrient imbalances that could be addressed before they lead to more noticeable symptoms. To get clear answers, consider ordering today.
Preparing for a Methylation and Genetic Marker Test
Fasting is not required for this test, so you can eat and drink as usual before collecting your sample. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Methylation Panel | Genova | Canada
| Test Name | Reference Range | What This Marker Means | Low and High Levels of Methylation Panel |
|---|---|---|---|
| Methionine | 15-45 | Methionine is an amino acid needed for starting the methylation cycle. It helps the body make proteins and supports detoxification. | High levels mean the body may not be converting methionine efficiently.
Low levels mean there may be a deficiency in dietary protein or issues with absorption. |
| S-adenosylmethionine (SAM) | 80-120 | SAM is a key compound that donates methyl groups for many body processes, including mood regulation and DNA repair. | High levels mean methylation is active but may not be balanced.
Low levels mean the body may struggle with methylation, affecting mood and energy. |
| S-adenosylhomocysteine (SAH) | 10-22 | SAH is a byproduct of methylation. High levels can slow down methylation and affect detoxification. | High levels mean methylation is blocked or slowed.
Low levels mean methylation is likely working efficiently. |
| Homocysteine | 5-12 | Homocysteine is an amino acid linked to heart and brain function. It is recycled in the methylation pathway. | High levels mean increased risk for heart and memory problems.
Low levels mean the body is efficiently recycling homocysteine. |
| Cystathionine | 0.10-0.40 | Cystathionine is a step in converting homocysteine to cysteine, supporting antioxidant production and detoxification. | High levels mean a block in the pathway from homocysteine to cysteine.
Low levels mean possible issues with enzyme activity or nutrient intake. |
| Cysteine | 200-300 | Cysteine is an amino acid needed for making glutathione, the body’s main antioxidant, and for detoxification. | High levels mean possible issues with glutathione production.
Low levels mean reduced antioxidant support and detoxification. |
| Glutathione (GSH) | 900-1800 | Glutathione is a powerful antioxidant that protects cells from damage and supports detoxification. | High levels mean the body is responding to increased oxidative stress.
Low levels mean reduced ability to handle toxins and oxidative stress. |
| Taurine | 40-120 | Taurine is an amino acid that helps with bile production, heart rhythm, and calming the nervous system. | High levels mean increased need for detoxification or stress response.
Low levels mean possible issues with bile flow or nervous system support. |
| Glycine | 200-400 | Glycine is an amino acid important for making proteins, supporting sleep, and helping the body detoxify. | High levels mean the body may be breaking down more protein or have trouble using glycine.
Low levels mean reduced support for detoxification and sleep. |
| Serine | 80-180 | Serine is an amino acid needed for making proteins and supporting the nervous system. | High levels mean possible issues with metabolism or protein breakdown.
Low levels mean reduced support for brain and nerve function. |
| Sarcosine | 0.5-2.5 | Sarcosine is a byproduct of glycine metabolism and is involved in methylation and energy production. | High levels mean increased breakdown of glycine or changes in methylation.
Low levels mean reduced methylation activity or energy production. |
| Choline | 7-20 | Choline is a nutrient needed for brain function, memory, and methylation. It also helps make cell membranes. | High levels mean the body may not be using choline efficiently.
Low levels mean possible memory issues and reduced methylation support. |
| Betaine | 30-70 | Betaine helps recycle homocysteine and supports methylation, protecting the heart and brain. | High levels mean the body is trying to lower homocysteine.
Low levels mean reduced support for methylation and homocysteine recycling. |
| Dimethylglycine (DMG) | 1-5 | DMG is a byproduct of betaine metabolism and supports energy, immune function, and methylation. | High levels mean increased betaine use or changes in methylation.
Low levels mean reduced support for energy and immune function. |
Reference ranges may change slightly as labs update their methods and guidelines.
Methylation Panel FAQ
Is there Methylation Panel testing near me?
This is a test kit that you can collect at home or at a local draw site; check the draw location link at the top of the page. For people experiencing ongoing fatigue or memory issues, having a nearby collection option makes it easier to get tested without added stress or travel.
How do I interpret the test results?
While your treating physician should review your results, we also offer a one-on-one test results review with our clinical team to help you understand your results and next steps.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, though draw fees may apply. Ordering this test can help you address nutrient imbalances that may be slowing your progress, so you can start feeling better sooner.
How often should I retest?
Retesting is usually recommended every 6 to 12 months, especially if you are making changes to your diet or supplements, to track improvements in methylation and nutrient status.
How accurate is the test?
This test uses plasma analysis for metabolites and buccal swab for genetic markers, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
None.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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