Ordering the CIRS Blood Test Panel
The CIRS Test Panel is a blood-based way to check how your immune system is responding to ongoing inflammation seen in CIRS testing. This CIRS blood test looks at markers like C4a, which can rise when the immune system stays switched on for too long, even after the trigger is gone.
Ordering the CIRS test helps piece together why symptoms may linger when routine labs look normal. This panel does not directly test for mold or toxin exposure; to evaluate that root cause, the MycoTox test is needed. For genetic inflammation sensitivity to mold, consider the HLA DR + DQ gene test.
- Developed by Dr. Richie Shoemaker
- Get tested with a simple blood draw through nationwide locations
- Includes optional VIP add-on for deeper neuroimmune insight
Why the CIRS Testing Is Important
The CIRS test measures signals like MMP-9 and TGFb-1, which help explain why inflammation can damage tissues and slow healing over time. When these markers stay high, the body may struggle to reset, even with lifestyle changes.
Recently, Jordan Peterson’s daughter, Mikhaila Peterson, has suggested that CIRS may be connected to his declining health, bringing wider attention to why early CIRS blood test data matters.
Why Someone Should Consider Ordering the Chronic Inflammatory Response Syndrome Blood Test
If you feel stuck with fatigue, brain fog, or hormone-like symptoms that never fully improve, CIRS testing can offer clarity. Markers like ADH and osmolality together can show why thirst, sleep, and energy feel off balance.
Ordering this CIRS blood test helps guide next steps with a provider, especially when symptoms affect daily life and answers feel out of reach.
Labs Included When Ordering Your CIRS Lab Test Panel
| Biomarker | Why It Matters | High / Low Meaning |
|---|---|---|
| C3a / C4a | These markers show how strongly the immune system is activated. They help explain lingering inflammation even when exposure has ended. | High: Ongoing immune activation and inflammation.
Low: Less immune system signaling. |
| MMP-9 | Reflects how inflammation may be affecting tissues and blood vessels. It is often linked to brain fog and body pain. | High: Increased tissue inflammation and barrier breakdown.
Low: Reduced inflammatory activity. |
| ADH | This hormone helps control fluid balance and thirst. Low levels can explain frequent urination and dehydration feelings. | High: Fluid retention or imbalance.
Low: Excess thirst and poor water regulation. |
| Osmolality | Measures how concentrated the blood is. It helps interpret ADH results and hydration stress. | High: Dehydration or fluid imbalance.
Low: Over-dilution or hormone regulation issues. |
| MSH | Supports sleep, mood, pain control, and gut health. Low levels are common in CIRS testing. | High: Rare in CIRS.
Low: Sleep disruption, pain, and mood changes. |
| VEGF | Helps regulate blood flow and oxygen delivery to tissues. Low levels may affect healing and endurance. | High: Excess blood vessel signaling.
Low: Poor circulation and exercise tolerance. |
| TGFb-1 | Plays a role in immune signaling and tissue repair. Elevated levels can drive ongoing inflammation. | High: Chronic immune dysregulation.
Low: Reduced immune signaling. |
| Leptin | Regulates appetite and metabolism. In CIRS, levels may be abnormal regardless of body weight. | High: Leptin resistance and inflammation.
Low: Metabolic signaling disruption. |
| VIP (Optional Add-On) | Supports hormone balance, gut health, and inflammation control. Often low in advanced CIRS cases. | High: Rare and uncommon clinically.
Low: Poor symptom regulation and immune balance. |
References can change over time. Check lab for most recent ranges.
According to PubMed, abnormalities in multiple inflammatory markers can persist long after exposure, helping explain chronic symptoms despite avoidance.
CIRS Panel FAQ
Is there CIRS testing near me?
Yes. This CIRS blood test is drawn at nationwide locations, making ordering convenient. See the top of the page for the link to draw locations.
What is the cost of the test?
The price can be found at the top of the page and includes the blood draw.
Can you help me interpret my test results?
Your treating doctor should review results, but we can help explain them through our educational One-On-One Results Review.
How often should I retest?
Most people retest every 3–6 months to track improvement. This matters because trends are more helpful than single results.
How accurate is the test?
The panel uses standardized blood immunoassays with high sensitivity and specificity. Testing is performed at a CLIA-certified laboratory.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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