Leaky Gut Test (Intestinal Permeability Test) | Lactulose and Mannitol Test
The Leaky Gut Test (or Intestinal Permeability Test) is a noninvasive gastrointestinal test that measures small intestinal absorption and barrier function in the bowel. Malabsorption and increased intestinal permeability (leaky gut) can be associated with chronic gastrointestinal imbalances.
How Does the Leaky Gut Test Work?
The Leaky Gut Test requires you to take a baseline morning urine sample (done at home). Once completed, you will be required to drink a mixture of two non-metabolized sugars, lactulose, and mannitol. After six hours, you will collect an additional sample of urine. The lab will measure how much lactulose and mannitol were excreted.
If Leaky Gut Syndrome is NOT present, the large lactulose molecules should remain in the GI tract and thus test low in the urine. If the count is high in the urine, Leaky Gut Syndrome should be considered.
Possible Causes of Leaky Gut:
- Intestinal infection (test panel)
- Ingestion of allergenic foods (test panel)
- Toxic chemicals (test panels)
- NSAIDs such as aspirin, ibuprofen, naproxen etc.
How Can The Leaky Gut Test Help?
The Leaky Gut Test is extremely important when beginning restorative treatment plans. As intestinal health improves, the lactulose/mannitol ratio should improve.
Since ongoing monitoring is recommended by most doctors, we extend a 10% discount when you order 2 or more leaky gut tests at the same time (automatically discounted at checkout).
What’s Being Tested in this Panel?
- Total Urine Volume
- Includes: Mannitol/Lactulose Drink
To prevent an incorrect mannitol reading, please avoid the following foods 48 hours before collection:
- Cough Drops
- Hard and Soft Candies
- Lactobacillus Probiotic Supplementation
Fasting: See instructions
Turnaround Time: 7-10 Business Days
- This kit can be ordered only within the US states including New York State.
- This kit is not intended for those with kidney dysfunction.
- Do not run the test if you have allergies to Mannitol or Lactulose.
- Certain medications such as aspirin, other anti-inflammatory drugs, antacids containing aluminum or magnesium hydroxide (eg, Maalox liquid, Equate, Milk of Magnesia, Rolaids, Mylanta) as well as drugs that contain sorbitol and/or mannitol may affect your test results. Please consult with your healthcare professional know about any medications or supplements you are using before taking this test. It is recommended that you avoid the use of these medicines for at least 72 hours before taking this test.