Ordering the NeoComplete Paraneoplastic Evaluation with Recombx
Ordering the NeoComplete Paraneoplastic Evaluation with Recombx helps detect specific autoantibodies linked to paraneoplastic neurological syndromes, which can cause symptoms like muscle weakness, memory loss, and coordination problems. Interestingly, some of these autoantibodies may appear before a cancer diagnosis, offering a window for early detection and targeted care.
When ordering this test, you gain access to several specific benefits:
- Identifies a wide range of paraneoplastic autoantibodies, including rare markers not found in standard panels.
- Supports early detection of neurological symptoms that may be related to underlying tumors.
- Helps distinguish between autoimmune and non-autoimmune causes of neurological symptoms.
- Guides your healthcare provider in choosing the most appropriate follow-up tests or treatments.
- Reduces the risk of misdiagnosis by providing a comprehensive antibody profile.
Who Should Consider Comprehensive Paraneoplastic Antibody Screening
People who have unexplained neurological symptoms—such as sudden memory loss, muscle weakness, or changes in mood—may benefit from this test. For example, someone experiencing new-onset seizures and confusion, without a clear cause, could use this test to help uncover an underlying autoimmune or paraneoplastic process.
Ordering this test may also be helpful in these situations:
- Persistent dizziness and balance issues that do not improve with standard treatments
- Unexplained joint pain and inflammation with neurological symptoms
- Visual changes or double vision that develop alongside fatigue and night sweats
- Speech or swallowing difficulties that appear suddenly and progress over weeks
- Someone with a history of cancer who now has new neurological symptoms, as these may be linked to paraneoplastic syndromes
Testing for these autoantibodies can help pinpoint the cause of neurological symptoms, allowing for more targeted treatment and monitoring. Delaying this test could mean missing the chance to detect an underlying autoimmune or paraneoplastic process early, which may affect treatment options and outcomes.
Preparing for Paraneoplastic Autoantibody Panel Testing
Fasting is not required before this blood test, so you can eat and drink as usual. Always follow any specific instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your NeoComplete Paraneoplastic Evaluation with Recombx
| Test Name | Reference Range | Significance | Low and High Levels of NeoComplete Paraneoplastic Evaluation with Recombx |
|---|---|---|---|
| Recombx® Amphiphysin Autoantibody Test | Negative | Detects antibodies against amphiphysin, which are linked to stiff-person syndrome and some paraneoplastic neurological disorders. This marker can help identify autoimmune causes of neurological symptoms. |
High levels mean there may be an autoimmune response often associated with certain cancers or neurological syndromes.
Low levels mean the marker is not detected, making paraneoplastic syndromes less likely. |
| CASPR2 Antibody Test | Negative | Identifies antibodies to CASPR2, which are linked to autoimmune encephalitis and neuromyotonia. This test helps clarify the cause of neurological symptoms like seizures or confusion. |
High levels mean possible autoimmune encephalitis or neuromyotonia.
Low levels mean CASPR2-related autoimmune conditions are unlikely. |
| GAD65 Neurological Syndrome Antibody Test | <5 IU/mL | Measures antibodies to GAD65, which are associated with stiff-person syndrome, epilepsy, and some forms of diabetes. This marker can help explain muscle stiffness or seizures. |
High levels mean increased risk for autoimmune neurological or metabolic disorders.
Low levels mean GAD65-related autoimmune activity is not present. |
| Ganglionic AChR Antibody Test | <0.02 nmol/L | Detects antibodies to ganglionic acetylcholine receptors, which can cause autonomic dysfunction. This test is useful for unexplained blood pressure changes, sweating, or digestive issues. |
High levels mean possible autoimmune autonomic neuropathy.
Low levels mean autonomic dysfunction from this cause is unlikely. |
| LEMS (VGCC) Antibody Test | <0.03 nmol/L | Measures antibodies to voltage-gated calcium channels, often found in Lambert-Eaton myasthenic syndrome. This marker helps explain muscle weakness and fatigue. |
High levels mean possible Lambert-Eaton myasthenic syndrome, often linked to cancer.
Low levels mean this syndrome is less likely. |
| LGI1 Autoantibody Test | Negative | Detects antibodies to LGI1, which are associated with autoimmune encephalitis. This test is helpful for people with seizures, memory loss, or confusion. |
High levels mean possible autoimmune encephalitis.
Low levels mean LGI1-related autoimmune activity is not detected. |
| NMDA Receptor (NR1-subunit) Autoantibody Test | Negative | Identifies antibodies to NMDA receptors, which can cause severe psychiatric and neurological symptoms. This marker is important for unexplained mood changes, psychosis, or seizures. |
High levels mean possible NMDA receptor encephalitis.
Low levels mean this autoimmune process is unlikely. |
| Recombx® CAR (Anti-Recoverin) Autoantibody Test | Negative | Detects antibodies to recoverin, which are linked to paraneoplastic retinopathy. This test is useful for unexplained vision problems. |
High levels mean possible paraneoplastic retinopathy.
Low levels mean this cause of vision problems is unlikely. |
| Recombx® CV2 Antibody Test | Negative | Measures antibodies to CV2, which are associated with paraneoplastic neurological syndromes. This marker can help explain unexplained neurological symptoms in people with a history of cancer. |
High levels mean possible paraneoplastic neurological syndrome.
Low levels mean CV2-related syndromes are unlikely. |
| Recombx® MaTa Autoantibody Test | Negative | Detects MaTa antibodies, which are linked to paraneoplastic brainstem encephalitis. This test is helpful for unexplained brainstem symptoms like double vision or swallowing problems. |
High levels mean possible paraneoplastic brainstem encephalitis.
Low levels mean this condition is unlikely. |
| Recombx® Ri Autoantibody Test | Negative | Identifies Ri antibodies, which are associated with paraneoplastic opsoclonus-myoclonus syndrome. This marker is important for people with rapid, involuntary eye movements and muscle jerks. |
High levels mean possible paraneoplastic opsoclonus-myoclonus syndrome.
Low levels mean this syndrome is unlikely. |
| Recombx® Yo Autoantibody Test | Negative | Detects Yo antibodies, which are linked to paraneoplastic cerebellar degeneration. This test is useful for unexplained balance and coordination problems. |
High levels mean possible paraneoplastic cerebellar degeneration.
Low levels mean this cause of symptoms is unlikely. |
| Recombx® Zic4 Antibody Test | Negative | Measures Zic4 antibodies, which are associated with paraneoplastic cerebellar degeneration. This marker helps explain new balance or coordination issues. |
High levels mean possible paraneoplastic cerebellar degeneration.
Low levels mean Zic4-related syndromes are unlikely. |
| Recombx® Hu Autoantibody Test | Negative | Detects Hu antibodies, which are linked to paraneoplastic encephalomyelitis and sensory neuropathy. This test is important for unexplained nerve pain or sensory changes. |
High levels mean possible paraneoplastic encephalomyelitis or neuropathy.
Low levels mean Hu-related syndromes are unlikely. |
| VGKC Antibody Test | Negative | Identifies antibodies to voltage-gated potassium channels, which are linked to autoimmune encephalitis and neuromyotonia. This marker helps explain muscle twitching, seizures, or confusion. |
High levels mean possible autoimmune encephalitis or neuromyotonia.
Low levels mean VGKC-related autoimmune activity is not detected. |
Reference ranges may change slightly as labs update their methods and standards. Always review your results with your healthcare provider for the most current interpretation.
NeoComplete Paraneoplastic Evaluation with Recombx FAQ
Is there NeoComplete Paraneoplastic Evaluation with Recombx testing near me?
This test is provided as a kit that can be collected at a local draw site—check the draw location link for options. For people experiencing symptoms like unexplained memory loss or muscle weakness, having a nearby collection site makes it easier to get tested quickly and start finding answers.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price for this test includes standard shipping to you and return shipping to the lab; draw fees may apply at the collection site. Ordering this test can help you and your provider quickly identify the cause of neurological symptoms, which may speed up the process of getting the right treatment.
How often should I retest?
Retesting is usually recommended if new neurological symptoms develop or if your provider needs to monitor changes in antibody levels over time. Repeating the test can help track disease progression or response to treatment, making it easier to adjust your care plan as needed.
How accurate is the test?
This panel uses advanced immunoblot and cell-based assay methods, with a specificity of 99% and sensitivity of 97% for most markers. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test cannot be collected in NY, NJ, MA, and RI. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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