Ordering the MTHFR Combined | Genomic Profile
The MTHFR Combined | Genomic Profile helps identify specific genetic changes in the MTHFR gene, which can affect how the body processes folate and vitamin B12. This information is useful for people who want to know if they have a higher chance of issues like blood clotting, mood changes, or trouble with nutrient absorption. Interestingly, some people with MTHFR gene changes may not show any symptoms but can still pass these changes to their children.
Ordering this test can help you:
- Find out if you have the A1298C or C677T MTHFR gene changes
- Learn if your body may have trouble turning folic acid into its active form
- See if you are at higher risk for high homocysteine, which can affect your heart and blood vessels
- Get information that can help guide your vitamin and supplement choices
- Support your doctor in making decisions about your care, especially if you have unexplained symptoms
Who Should Consider Genetic Methylation Testing
People who have a family history of heart disease, frequent migraines, or mood changes may benefit from this test. For example, someone who has tried different treatments for fatigue and memory problems without answers might find this test helpful in finding a possible genetic reason.
Ordering this test may also be helpful if you:
- Have a personal or family history of blood clots or stroke
- Are planning a pregnancy or have had trouble with pregnancy in the past
- Experience chronic pain, especially if it does not improve with usual treatments
- Have low vitamin B12 or folate levels that do not improve with supplements
- Have a history of mood swings or depression that started after a period of high stress, which can sometimes reveal hidden genetic factors
Testing for these gene changes can help you and your doctor make more informed choices about supplements, diet, and other treatments. Delaying this test could mean missing out on targeted steps that may help lower your risk for certain conditions.
Preparing for Your MTHFR Genetic Mutation Analysis
Fasting is not needed for this test, and you can collect your sample at any time of day. Always follow the instructions provided by your doctor or healthcare provider to make sure your sample is collected and sent correctly.
Labs Included When Ordering Your MTHFR Combined | Genomic Profile
| Test Name | Reference Range | What the Test Measures | Low and High Levels of MTHFR Combined | Genomic Profile |
|---|---|---|---|
| Methylenetetrahydrofolate Reductase Combined (A1298C + C677T) | Normal: No mutation Heterozygous: One copy of A1298C or C677T Homozygous: Two copies of A1298C or C677T |
This test checks for two common changes in the MTHFR gene, A1298C and C677T. These changes can affect how your body uses folate and vitamin B12, which are important for making energy and keeping your blood vessels healthy. |
High levels mean you have two copies of a gene change, which can raise your risk for high homocysteine, blood clots, and trouble with folate use.
Low levels mean you have no gene changes, so your body likely uses folate and vitamin B12 as expected. |
Reference ranges may change slightly as labs update their methods and guidelines.
MTHFR Combined | Genomic Profile FAQ
Is there MTHFR Combined | Genomic Profile testing near me?
This is a test kit you can use at home, and you can check the draw location link at the top of the page for local collection options. For people with unexplained fatigue or mood changes, having a nearby collection site makes it easier to get tested without extra travel or stress.
How do I interpret the test results?
While your doctor should review your results with you, we also offer a one-on-one test results review with our clinical team to help you understand what your results mean and what steps you can take next.
What is the cost of the test?
The price you see includes standard shipping to you and back to the lab, but draw fees may apply if you use a local collection site. Ordering this test can help you find out if a genetic change is affecting your energy, mood, or risk for blood clots, so you can take steps to feel better sooner.
How often should I retest?
Since your genes do not change, you only need to do this test once unless your doctor suggests retesting for another reason. Retesting may be helpful if you need to confirm results or if new research changes how gene changes are reported.
How accurate is the test?
This test uses polymerase chain reaction (PCR) to detect MTHFR gene changes, with a specificity of 99.9% and a sensitivity of 99.8%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This kit cannot be mailed or collected in New York State. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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