Ordering the Methylation Profile By Doctor’s Data
Ordering the Methylation Profile By Doctor’s Data helps identify how your body processes and uses nutrients that support brain function, energy, and detoxification. This test measures key markers in the methylation and transsulfuration pathways, which are linked to mood, memory, and how your body handles toxins. Interestingly, a low ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) can be an early sign of under-methylation, which may not show up in routine blood work.
When ordering this test, you gain access to specific benefits:
- Pinpoints imbalances in methylation that may affect mood, memory, and focus
- Reveals nutrient deficiencies, such as B12 or folate, that impact DNA repair and energy
- Assesses detoxification capacity by measuring glutathione pathway markers
- Identifies genetic or nutritional factors that may increase inflammation
- Provides a clear methylation index to guide targeted nutrition or supplement plans
Who Should Consider Advanced Methylation and Detoxification Testing
People who feel tired even after a full night’s sleep, struggle to remember things, or notice mood changes that don’t improve with rest may benefit from this test. For example, someone who has tried different diets and supplements but still feels mentally foggy and low on energy could use this test to find out if their body is missing key nutrients or not processing them well.
Ordering this test may also be helpful in these situations:
- Frequent mood swings or trouble concentrating despite lifestyle changes
- Family history of heart disease or early memory loss
- Long-term exposure to environmental toxins, such as heavy metals
- Chronic fatigue that does not improve with rest or diet changes
- Unexplained skin issues that may be linked to detoxification problems
This test can show if your body is missing important nutrients or not using them properly, which can affect how you think, feel, and recover from stress. Delaying this test may mean missing the chance to address nutrient imbalances before they lead to more noticeable problems.
Preparing for Plasma Methylation and Transsulfuration Analysis
Fasting is not required for this test, so you can eat and drink as usual before your sample is collected. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Methylation Profile By Doctor’s Data
| Test Name | Reference Range | What This Marker Means | Low and High Levels of Methylation Profile By Doctor’s Data |
|---|---|---|---|
| Methionine, plasma | 15-45 | Methionine is an amino acid needed for making proteins, DNA repair, and starting the methylation cycle. It is the first step in the process that helps your body use nutrients for energy and detoxification. |
High levels mean your body may not be converting methionine properly, which can lead to build-up and possible inflammation.
Low levels mean you may not be getting enough from your diet or your body is using it up too quickly, which can affect energy and brain function. |
| Homocysteine, plasma | 4-10 | Homocysteine is a byproduct of methionine metabolism. It is recycled back to methionine or converted to cysteine, and high levels are linked to heart and brain problems. |
High levels mean your body may not be recycling homocysteine well, which can increase risk for heart and memory issues.
Low levels mean your body is efficiently processing homocysteine, or you may have low methionine intake. |
| Cystathionine, plasma | 0.05-0.25 | Cystathionine is made from homocysteine and is a step toward making cysteine, which is needed for glutathione, a key antioxidant. |
High levels mean your body may be having trouble converting cystathionine to cysteine, which can affect detoxification.
Low levels mean your body may not be making enough cystathionine, which can limit antioxidant production. |
| Cysteine, plasma | 200-300 | Cysteine is an amino acid made from cystathionine and is needed to make glutathione, which helps your body fight stress and toxins. |
High levels mean your body may be breaking down too much protein or not using cysteine for glutathione.
Low levels mean you may not be making enough cysteine, which can lower your body’s ability to handle toxins. |
| S-adenosylmethionine (SAM), plasma | 80-120 | SAM is the main methyl donor in the body, helping with DNA repair, neurotransmitter production, and detoxification. It is made from methionine. |
High levels mean your body may not be using SAM efficiently, which can affect methylation and brain function.
Low levels mean you may not have enough methyl donors, which can slow down DNA repair and detoxification. |
| S-adenosylhomocysteine (SAH), plasma | 10-22 | SAH is made when SAM donates a methyl group. High SAH can block methylation, affecting DNA repair and neurotransmitter balance. |
High levels mean methylation is slowed down, which can impact memory, mood, and detoxification.
Low levels mean your body is efficiently removing SAH, supporting healthy methylation. |
| SAM:SAH Ratio (Methylation Index) | >4.5 | This ratio shows how well your body is methylating. A higher ratio means better methylation, which supports brain, mood, and detoxification functions. |
High levels mean your body is methylating well, supporting DNA repair and neurotransmitter balance.
Low levels mean methylation is not working well, which can affect memory, mood, and how your body handles toxins. |
Reference ranges may change slightly as labs update their methods and guidelines. Always check your report for the most current values.
Methylation Profile By Doctor’s Data FAQ
Is there Methylation Profile By Doctor’s Data testing near me?
This is a test kit that you can have collected at a local draw site—check the draw location link at the top of the page. For those experiencing ongoing fatigue or memory issues, having a nearby collection site makes it easier to get tested quickly and start finding answers.
How do I interpret the test results?
While your treating physician should always help you interpret your results, we also offer a one-on-one test results review with our clinical team to help you understand your results and next steps.
What is the cost of the test?
The price you see for the test includes standard shipping to you and back to the lab, but draw fees may apply at your local collection site. Ordering this test can help you address nutrient imbalances that may be slowing your recovery from fatigue, brain fog, or mood changes.
How often should I retest?
Retesting is usually recommended every 6-12 months, especially if you are making changes to your diet or supplements, so you can track improvements in methylation and detoxification markers.
How accurate is the test?
This test uses high-performance liquid chromatography (HPLC) with mass spectrometry for precise measurement of methylation markers, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This kit cannot be mailed and collected in New York State.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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