Lyme IgXSpot Test

Ordering the Lyme IgXSpot Test

The Lyme IgXSpot Test helps detect both early and late stages of Lyme disease by measuring T-cell responses, which can be present even when antibodies are not. This is especially useful for people who may not produce enough antibodies for standard Lyme tests, such as those with chronic symptoms or early exposure. Interestingly, the IgXSpot method can identify Lyme infection in people who have trouble making antibodies, which is a common issue in chronic Lyme cases.

Ordering this test provides several specific benefits:

• Detects Lyme disease even when antibody tests are negative.
• Identifies both early and late-stage Lyme infection.
• Uses a blood sample, making it accessible for most people.
• Helps guide treatment decisions by showing immune system activity.
• Reduces the risk of missed or delayed diagnosis in complex cases.

Who Should Consider T-Cell Lyme Testing

People who have ongoing joint pain, fatigue, or neurological symptoms after a tick bite may benefit from this test, especially if standard Lyme tests have been negative. For example, someone who has experienced months of unexplained muscle pain and memory problems after spending time in wooded areas might find this test helpful in finding answers.

Ordering this test may also be useful in these situations:

• Persistent flu-like symptoms after outdoor activities in tick-prone regions
• Unexplained facial palsy or sudden dizziness with a history of tick exposure
• Chronic fatigue and mood changes following a known or suspected tick bite
• Eye inflammation or skin lesions that do not respond to standard treatments
• Unusual heart palpitations that started after a camping trip in an area known for ticks

Testing for Lyme disease using this method can help confirm or rule out infection when other tests are unclear, providing clear results that can guide next steps. Delaying this test may allow symptoms to continue without a clear cause, making it harder to start the right treatment.

Preparing for Your Lyme T-Cell Assay

Fasting is not required before this blood test, so you can eat and drink as usual. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.

Labs Included When Ordering Your Lyme IgXSpot Test

Reference ranges may change slightly as labs update their methods and standards over time.

Lyme IgXSpot FAQ

Is there Lyme IgXSpot testing near me?

This is a test kit that you can use with a local blood draw site; check the draw location link at the top of the page for options. For people with ongoing symptoms like joint pain or fatigue, having a nearby collection site makes it easier to get tested quickly and start finding answers.

How do I interpret the test results?

While your treating physician should always review your results, we also offer a one-on-one test results review with our clinical team to help you understand what your results mean and what steps to take next.

What is the cost of the test?

The price listed for this test includes standard shipping to you and return shipping to the lab; draw fees at your local site may be extra. Ordering this test can help you get a clear answer about Lyme infection, which may speed up the process of getting the right treatment.

How often should I retest?

Retesting is usually recommended 4-6 weeks after starting or changing treatment, or if symptoms return after a period of improvement. Repeating the test can show if your immune response to Borrelia burgdorferi is changing, which helps track progress and guide next steps.

How accurate is the test?

This test uses the Enzyme-Linked ImmunoSpot (ELISPOT) method, which detects T-cell responses to Borrelia burgdorferi with a sensitivity of 94% and specificity of 98%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.