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Lyme Disease Antibody Test


  • Draw Locations
  • Turnaround Time: 2-4 Business Days on Average. Time may vary.
  • Not Available in: NY, NJ, MA, and RI
  • HSA and FSA Approved

$249.00 USD $272.00

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Ordering the Lyme Disease Antibody Test

Ordering the Lyme Disease Antibody Test helps detect antibodies to Borrelia burgdorferi, the bacteria that causes Lyme disease, which is often spread by tick bites. This test is especially useful for people who have symptoms that may be linked to Lyme disease, such as joint pain, memory problems, or a rash that looks like a bull’s-eye. Interestingly, Lyme disease can sometimes cause symptoms that mimic other conditions, making lab testing a key step in finding the right diagnosis.

When ordering the Lyme Disease Antibody Test, you gain several specific benefits:

  • Identifies both early and late-stage Lyme disease by measuring total and IgM antibodies.
  • Helps confirm if symptoms like joint pain or fatigue are related to Lyme disease.
  • Supports your doctor in choosing the right treatment plan based on your results.
  • Can rule out Lyme disease when symptoms overlap with other conditions.
  • Provides a clear starting point for further testing, such as the Western Blot confirmation test.

Who Should Consider Lyme Disease Screening

People who spend time outdoors in grassy or wooded areas, especially in regions where ticks are common, may benefit from this test. For example, someone who recently went hiking and later noticed a strange rash and ongoing tiredness might want to check for Lyme disease to understand the cause of their symptoms.

Ordering this test may also be helpful in these situations:

  • After finding a tick attached to your skin, even if you did not notice a bite.
  • If you have unexplained joint pain or swelling that does not improve.
  • When you experience memory loss or mood changes without a clear reason.
  • If you have been diagnosed with fibromyalgia but symptoms started after outdoor activities.
  • When a family member or pet has recently been treated for Lyme disease, as ticks can affect multiple people in the same area.

Testing for Lyme disease can help pinpoint the cause of symptoms like joint pain, memory issues, or unusual rashes, allowing for targeted treatment and follow-up. Delaying this test may lead to ongoing symptoms and make it harder to confirm the diagnosis later, as antibody levels can change over time. To move forward, consider ordering the test if any of these situations apply to you.

Preparing for Lyme Disease Antibody Screening

Fasting is not required before this blood test, so you can eat and drink as usual. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as helpful as possible.

Labs Included When Ordering Your Lyme Disease Antibody Test

Test Name Reference Range What This Biomarker Means Low and High Levels of Lyme Disease Antibody Test
Lyme Disease Antibodies – Total Negative: <0.90
Equivocal: 0.91-1.09
Positive: >1.10
This test measures the total amount of antibodies your body has made against Borrelia burgdorferi. It helps show if you have been exposed to the bacteria that causes Lyme disease. High levels mean your immune system has responded to the Lyme bacteria, which may indicate a current or past infection.

Low levels mean there is little or no evidence of exposure to the Lyme bacteria.

Lyme Disease Antibodies – IgM Negative: <0.90
Equivocal: 0.91-1.09
Positive: >1.10
IgM antibodies are the first type your body makes after being exposed to Borrelia burgdorferi. This marker is most useful for detecting early or recent Lyme disease. High levels mean you may have a recent or active Lyme infection.

Low levels mean there is no sign of a recent Lyme infection.

Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.


Lyme Disease Antibody Test FAQ

Is there Lyme Disease Antibody testing near me?

You can find a nearby location for Lyme Disease Antibody testing using the patient service center locator, which also lists mobile phlebotomy options. This is especially helpful if you need quick access to testing after a tick bite or if traveling to a distant lab is difficult due to joint pain or fatigue.

What is the cost of the test?

The price you see for the Lyme Disease Antibody Test includes all fees, including sample collection at patient service center locations. Ordering this test is worth it because it can help explain symptoms like joint pain or memory problems that may be linked to Lyme disease.

How often should I retest?

Retesting is usually recommended if symptoms return or if your doctor suggests it after treatment, often within a few weeks to a few months. Repeating the test can help track changes in antibody levels and confirm if treatment has worked or if further steps are needed.

How accurate is the test?

The Lyme Disease Antibody Test uses an enzyme immunoassay (EIA) method to detect antibodies, with a sensitivity of about 89% and a specificity of about 98%. All tests at TrueHealthLabs.com are performed by CLIA-certified labs, meeting strict quality and precision standards.


Medical Review Board

Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.

Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.


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