Ordering the Histamine Blood Test | HDRI
The Histamine Blood Test by HDRI helps measure histamine levels in your blood, which can be linked to symptoms like hives, headaches, digestive upset, and skin rashes. This test is often used to help find out if symptoms are related to histamine intolerance, allergies, or other immune system reactions. Interestingly, histamine is not only involved in allergic reactions but also plays a role in regulating sleep and stomach acid production.
Ordering this test can help you and your healthcare provider:
- Identify if high or low histamine is causing symptoms like flushing, itching, or digestive issues
- Guide treatment for allergy-like symptoms that do not respond to standard allergy medications
- Monitor histamine levels if you have a known intolerance or mast cell disorder
- Track changes in histamine after starting a new diet or medication
- Support diagnosis of rare conditions like mastocytosis or histamine intolerance
Who Should Consider Histamine Level Testing
If you have been dealing with unexplained rashes, headaches, or stomach cramps that seem to come and go, this test may help find the cause. For example, someone who gets hives after eating certain foods or experiences sudden flushing and dizziness might benefit from checking their histamine levels.
Ordering this test may also be helpful in these situations:
- Frequent sneezing, runny nose, or congestion not linked to seasonal allergies
- Digestive problems like bloating, diarrhea, or nausea after eating aged or fermented foods
- Skin conditions such as eczema or unexplained itching
- Recurring headaches or migraines that do not improve with usual treatments
- People with chronic fatigue who notice symptoms worsen after stress or certain foods
Testing for histamine can help pinpoint the reason for symptoms that overlap with allergies, food intolerances, or mast cell disorders, making it easier to choose the right treatment. Delaying this test could mean missing the chance to adjust your diet or treatment plan sooner, which may lead to ongoing symptoms.
Preparing for Blood Histamine Measurement
A 12-hour fast is recommended before your blood is drawn for this test. Make sure to follow any specific instructions your doctor or healthcare provider gives you, as these can affect your results and help you get the most useful information from your test.
Labs Included When Ordering Your Histamine Blood Test | HDRI
| Test Name | Reference Range | What This Biomarker Means | Low and High Levels of Histamine Blood Test | HDRI |
|---|---|---|---|
| Histamine | 0.3 – 1.0 ng/mL | Histamine is a chemical released by the immune system during allergic reactions and helps regulate stomach acid and sleep. Measuring histamine in the blood can help identify allergies, food intolerances, or mast cell disorders. |
High levels mean your body may be reacting to allergens, certain foods, or have a mast cell disorder.
Low levels mean your body may not be producing enough histamine, which can affect digestion and immune response. |
Reference ranges may change slightly as labs update their methods or as new research becomes available. Always check your report for the most current values.
Histamine Blood Test | HDRI FAQ
Is there Histamine Blood Test | HDRI testing near me?
This test is available as a kit that can be collected at a local draw site—use the draw location link at the top of the page to find a nearby option. For those experiencing symptoms like sudden hives or digestive upset, having a convenient collection site makes it easier to get tested quickly and start finding answers.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price you see includes standard shipping to you and back to the lab, though a draw fee may apply at the collection site. Ordering this test can help you address symptoms like unexplained rashes or headaches sooner, so you can work toward feeling better faster.
How often should I retest?
Retesting is usually recommended every 3 to 6 months if you are monitoring histamine levels for ongoing symptoms or after starting a new treatment. Regular testing helps track changes and guides adjustments to your care plan.
How accurate is the test?
This test uses high-performance liquid chromatography (HPLC) with fluorescence detection, which is highly specific for histamine measurement. The test has a specificity of 98% and a sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test cannot be mailed and collected in New York state.
- If permitted by your primary doctor, stop all medications 48 hours prior to blood collection.
- Avoid all caffeine products and smoking 24 hours prior to collection.
- You should rest 30 minutes before venipuncture.
- Blood should be drawn when you are in a supine position.
- A 12-hour fast is recommended.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
Why Customers Trust True Health Labs - What People are saying
Also rated 4.6 out of 5 based on 3452 ShopperApproved reviews- See all TrueHealthLabs.com reviews.
