Ordering the EstroGenomic Profile
The EstroGenomic Profile helps identify how your body processes estrogen and related hormones, which can affect symptoms like bloating, mood changes, and weight gain. This test can also reveal genetic markers linked to breast cancer risk, heart disease, and osteoporosis. Interestingly, certain genetic variations tested here can influence how your body breaks down environmental toxins, which may impact hormone balance and long-term health.
Ordering the EstroGenomic Profile provides:
- Personalized information about your estrogen metabolism and detoxification pathways
- Genetic markers that may affect your risk for hormone-related conditions
- Insight into how your body handles blood clotting and cardiovascular risk
- Details about bone health and osteoporosis risk factors
- Guidance for targeted nutrition and lifestyle changes based on your genetic results
Who Should Consider Hormone and Genetic Risk Testing
People experiencing ongoing symptoms like irregular periods, unexplained fatigue, or mood swings may benefit from this test, especially if these issues have not improved with standard care. For example, someone who has tried several treatments for PMS or menopause symptoms without relief may find that genetic testing uncovers hidden factors affecting their hormone balance.
Ordering this test may also be helpful in these situations:
- Family history of breast, ovarian, or prostate cancer
- Recurring headaches or migraines that seem linked to hormonal changes
- Difficulty losing weight despite healthy eating and exercise
- Unexplained infertility or repeated pregnancy loss
- Unexpected connection: People with a history of blood clots or unexplained bruising may discover genetic markers that affect clotting and hormone metabolism
Testing for these genetic markers can help you and your doctor make informed decisions about hormone therapy, supplements, and lifestyle changes. Delaying this test could mean missing the chance to address genetic factors that may be affecting your symptoms or increasing your risk for certain conditions.
Preparing for Genetic and Hormone Metabolism Testing
Fasting is not required for this test, but be sure to follow the instructions included in your Genova Diagnostics test kit for the buccal swab collection. Always go by any specific directions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your EstroGenomic Profile
| Test Name | Reference Range | What This Test Measures | Low and High Levels of EstroGenomic Profile |
|---|---|---|---|
| Estrogen Metabolism | |||
| CYP1A1 | Normal: 1-2 copies | CYP1A1 is a gene that helps break down estrogen into less active forms. It also helps process toxins from the environment. | High levels mean faster estrogen breakdown, which may lower estrogen activity.
Low levels mean slower estrogen breakdown, which may increase estrogen effects in the body. |
| CYP1B1 | Normal: 1-2 copies | CYP1B1 helps convert estrogen into forms that can be more active or potentially harmful if not balanced by other pathways. | High levels mean increased production of active estrogen forms, which may raise risk for hormone-related symptoms.
Low levels mean less conversion, which may reduce risk but also affect hormone balance. |
| COMT (catechol-O-methyl transferase) | Normal: 1-2 copies | COMT helps clear estrogen and stress hormones from the body. It also affects mood and mental focus. | High levels mean faster clearance of estrogen and stress hormones, which may lower hormone effects.
Low levels mean slower clearance, which may increase hormone buildup and mood changes. |
| GST (M1 and P1) | Normal: 1-2 copies | GST genes help detoxify harmful substances and support estrogen metabolism. They also protect cells from damage. | High levels mean better detoxification and cell protection.
Low levels mean reduced detox ability, which may increase toxin buildup and hormone imbalance. |
| HyperCoagulation | |||
| GP3a (Glycoprotein 3) | Normal: 1-2 copies | GP3a is involved in blood clotting. Variations can affect how easily blood clots form. | High levels mean increased risk of blood clots.
Low levels mean lower risk of clotting, but may increase bleeding risk. |
| PAI-1 (Plasminogen activator inhibitor-1) | Normal: 1-2 copies | PAI-1 controls how quickly blood clots dissolve. It can affect risk for clotting or bleeding problems. | High levels mean slower clot breakdown, which may increase clot risk.
Low levels mean faster clot breakdown, which may increase bleeding risk. |
| Factor 2 (prothrombin) | Normal: 1-2 copies | Factor 2 is a protein needed for blood to clot. Genetic changes can increase or decrease clotting risk. | High levels mean higher risk of blood clots.
Low levels mean lower clotting ability, which may cause easy bruising or bleeding. |
| Factor 5 (Leiden) | Normal: 1-2 copies | Factor 5 Leiden is a genetic change that can make blood more likely to clot, especially with hormone therapy or pregnancy. | High levels mean increased risk of blood clots, especially in the legs or lungs.
Low levels mean normal clotting risk. |
| Cardiovascular | |||
| APOE (apolipoprotein E) | Normal: E3/E3 | APOE affects cholesterol levels and heart disease risk. Certain types can also affect memory and brain health. | High levels mean higher cholesterol and increased heart disease risk.
Low levels mean lower cholesterol and reduced risk. |
| MTHFR (C677T & A1298C polymorphisms) | Normal: 0-1 variant | MTHFR helps process folate and homocysteine. Variants can affect heart, mood, and pregnancy outcomes. | High levels mean higher homocysteine, which may increase heart and clotting risk.
Low levels mean normal processing and lower risk. |
| TNF-α (-308 G-A polymorphism) | Normal: G/G | TNF-α is a gene that controls inflammation. Variants can affect risk for heart disease and bone loss. | High levels mean increased inflammation and higher risk for heart and bone problems.
Low levels mean lower inflammation and reduced risk. |
| IL-6 (-174 G-C polymorphism) | Normal: G/G | IL-6 is another gene that affects inflammation and immune response. It can influence heart and bone health. | High levels mean more inflammation, which may increase risk for heart and bone issues.
Low levels mean less inflammation and lower risk. |
| Osteoporosis | |||
| VDR (BsmI RFLP) | Normal: B/B | VDR is the vitamin D receptor gene. It helps control how your body uses vitamin D for bone strength. | High levels mean better vitamin D use and stronger bones.
Low levels mean weaker vitamin D response, which may increase bone loss risk. |
| COL1A1 (collagen 1, α-1) | Normal: G/G | COL1A1 is a gene for collagen, a protein that gives bones strength and flexibility. Variants can affect bone density. | High levels mean stronger bones and lower fracture risk.
Low levels mean weaker bones and higher risk for osteoporosis. |
| TNF-α (-308 G-A polymorphism) | Normal: G/G | TNF-α also affects bone breakdown. Variants can increase risk for bone loss and osteoporosis. | High levels mean more bone breakdown and higher osteoporosis risk.
Low levels mean less bone loss and stronger bones. |
| IL-6 (-174 G-C polymorphism) | Normal: G/G | IL-6 also plays a role in bone health by controlling inflammation. Variants can affect bone strength and risk for fractures. | High levels mean increased bone loss and higher fracture risk.
Low levels mean better bone strength and lower risk. |
Reference ranges may change slightly as labs update their methods and guidelines. Always review your results with your healthcare provider for the most current information.
EstroGenomic Profile FAQ
Is there EstroGenomic Profile testing near me?
This is a test kit that you can collect at home using a buccal swab, and you can check the draw location link at the top of the page for local options. For people dealing with ongoing hormone symptoms, having a convenient collection site makes it easier to get tested without extra travel or delays.
How do I interpret the test results?
While your treating physician should always help you interpret your results, we also offer a one-on-one test results review with our clinical team to help you understand your genetic and hormone findings.
What is the cost of the test?
The price for the EstroGenomic Profile includes standard shipping to you and return shipping to the lab, but draw fees may apply. Ordering this test can help you address hormone-related symptoms more quickly by identifying genetic factors that may be affecting your treatment.
How often should I retest?
Retesting is usually only needed if your symptoms change, you start new hormone therapy, or your doctor recommends it based on your results. Repeating the test can help track how your genetic risk factors interact with new treatments or changes in your health.
How accurate is the test?
This test uses PCR-based DNA analysis to detect genetic variants, with a specificity of 99.9% and sensitivity of 99.8%. TrueHealthLabs.com works with CLIA-certified and CAP-certified labs to maintain high-quality testing standards you can trust.
Important Notes
- This kit cannot be mailed or collected in New York State. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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