Ordering the EstroGenomic Profile | Europe
Ordering the EstroGenomic Profile | Europe helps you learn how your body processes estrogen and related hormones, which can affect symptoms like mood swings, fatigue, and changes in bone strength. Interestingly, this test also checks for genetic markers that may influence how your body handles blood clotting and bone density, which many people do not realize are connected to hormone balance.
When ordering, you gain access to specific benefits:
- Identifies genetic markers that affect estrogen breakdown and hormone balance
- Assesses risk factors for blood clotting and cardiovascular changes
- Reveals genetic influences on bone strength and osteoporosis risk
- Highlights how your body may respond to hormone therapy or supplements
- Provides actionable information for managing symptoms like hot flashes, irregular periods, and mood changes
Who Should Consider Hormone and Genetic Risk Testing
People who have been experiencing ongoing symptoms such as irregular periods, unexplained weight gain, or mood changes may benefit from this type of testing. For example, someone who has tried different approaches to manage PMS or menopause symptoms but still feels tired, irritable, or has trouble concentrating could use this test to find out if genetics are playing a role.
Ordering may also be helpful in these situations:
- Someone with a family history of osteoporosis or early bone loss
- People who have noticed new or worsening breast tenderness or bloating
- Those with unexplained hair loss or skin changes
- Anyone with a personal or family history of blood clots or cardiovascular issues
- People who have had trouble with hormone therapy or birth control, as genetic differences can affect how these treatments work
This test is recommended for those who want to know if their symptoms are linked to how their body processes estrogen, blood clotting, or bone health. Delaying this test could mean missing the chance to make changes that may help reduce symptoms or prevent future problems related to hormone balance and genetic risk factors.
Preparing for Genetic and Hormone Metabolism Testing
Fasting is not required for this test, but always check the test kit instructions for any special steps before your blood draw. Make sure to follow whatever guidance your doctor or healthcare practitioner gives you, as this helps ensure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your EstroGenomic Profile | Europe
| Test Name | Reference Range | What This Marker Means | Low and High Levels of EstroGenomic Profile | Europe |
|---|---|---|---|
| Estrogen Metabolism | |||
| CYP1A1 | Wild type, Heterozygous, Homozygous variant | CYP1A1 is a gene that helps break down estrogen into different forms. Variations can affect how quickly or slowly estrogen is processed in the body. |
High levels mean faster estrogen breakdown, which may lower estrogen activity.
Low levels mean slower estrogen breakdown, which may increase estrogen effects. |
| CYP1B1 | Wild type, Heterozygous, Homozygous variant | CYP1B1 helps convert estrogen into forms that can be more or less active. Certain gene types may increase the production of stronger estrogen forms. |
High levels mean more active estrogen forms, which may raise risk for hormone-related symptoms.
Low levels mean less active estrogen forms, which may reduce estrogen effects. |
| COMT (catechol-O-methyl transferase) | Val/Val, Val/Met, Met/Met | COMT helps clear estrogen and stress hormones from the body. Variants can slow or speed up this process, affecting mood and hormone balance. |
High activity means faster removal of estrogen and stress hormones.
Low activity means slower removal, which may increase symptoms like anxiety or PMS. |
| GST (M1 and P1) | Present/Null | GST genes help detoxify estrogen byproducts. Variants can affect how well your body removes these byproducts, which may impact hormone-related symptoms. |
High activity means better detoxification of estrogen byproducts.
Low activity means slower detoxification, which may increase buildup of estrogen byproducts. |
| HyperCoagulation | |||
| GP3a (Glycoprotein 3) | Normal, Heterozygous, Homozygous variant | GP3a is involved in blood clotting. Variants can increase the risk of forming clots, especially when hormone levels change. |
High levels mean increased risk of blood clots.
Low levels mean lower risk of clotting problems. |
| PAI-1 (Plasminogen activator inhibitor-1) | Normal, Heterozygous, Homozygous variant | PAI-1 controls how quickly blood clots dissolve. Certain gene types can slow this process, raising the risk of clotting. |
High levels mean slower breakdown of clots, increasing clot risk.
Low levels mean faster breakdown, lowering clot risk. |
| Factor 2 (prothrombin) | Normal, Heterozygous, Homozygous variant | Factor 2 is a protein needed for blood to clot. Variants can make blood more likely to clot, especially with hormone changes. |
High levels mean increased risk of abnormal blood clots.
Low levels mean reduced clotting ability, which may cause bleeding. |
| Factor 5 (Leiden) | Normal, Heterozygous, Homozygous variant | Factor 5 Leiden is a gene change that raises the risk of blood clots, especially with hormone therapy or pregnancy. |
High levels mean much higher risk of blood clots.
Low levels mean normal clotting risk. |
| Cardiovascular | |||
| APOE (apolipoprotein E) | E2/E2, E2/E3, E3/E3, E3/E4, E4/E4 | APOE affects cholesterol and heart health. Certain types can increase the risk of heart disease, especially when combined with hormone changes. |
High risk types mean higher chance of heart disease.
Low risk types mean lower chance of heart problems. |
| MTHFR (C677T & A1298C polymorphisms) | Normal, Heterozygous, Homozygous variant | MTHFR helps process folate and homocysteine. Variants can raise homocysteine, which may increase risk for heart and blood vessel problems. |
High risk variants mean higher homocysteine and heart risk.
Low risk variants mean normal processing and lower risk. |
| TNF-α (-308 G-A polymorphism) | Normal, Heterozygous, Homozygous variant | TNF-α is a gene that controls inflammation. Certain types can increase inflammation, which may affect heart and bone health. |
High levels mean more inflammation, which may raise risk for heart and bone problems.
Low levels mean less inflammation and lower risk. |
| IL-6 (-174 G-C polymorphism) | Normal, Heterozygous, Homozygous variant | IL-6 is a gene that also controls inflammation. Variants can affect how much inflammation is present in the body, impacting heart and bone strength. |
High levels mean more inflammation, which may increase risk for heart and bone issues.
Low levels mean less inflammation and lower risk. |
| Osteoporosis | |||
| VDR (BsmI RFLP) | BB, Bb, bb | VDR is a gene for the vitamin D receptor. Variants can affect how well bones use vitamin D, which is important for bone strength. |
High activity means better bone use of vitamin D.
Low activity means weaker bones and higher osteoporosis risk. |
| COL1A1 (collagen 1, α-1) | Normal, Heterozygous, Homozygous variant | COL1A1 is a gene for collagen, a protein that gives bones strength. Variants can make bones more likely to break. |
High risk variants mean weaker bones and higher fracture risk.
Low risk variants mean stronger bones. |
| TNF-α (-308 G-A polymorphism) | Normal, Heterozygous, Homozygous variant | TNF-α also affects bone breakdown. Certain types can speed up bone loss, raising osteoporosis risk. |
High levels mean faster bone loss.
Low levels mean slower bone loss. |
| IL-6 (-174 G-C polymorphism) | Normal, Heterozygous, Homozygous variant | IL-6 can also affect how quickly bones break down. Variants may increase or decrease the risk of osteoporosis. |
High levels mean increased bone breakdown and higher osteoporosis risk.
Low levels mean less bone breakdown. |
Reference ranges may change slightly as labs update their standards or as new research becomes available.
EstroGenomic Profile | Europe FAQ
Is there EstroGenomic Profile | Europe testing near me?
This is a test kit that can be collected at a local draw site; check the draw location link at the top of the page. For people dealing with symptoms like hormone imbalance or bone changes, having a nearby collection site makes it easier to get tested quickly and start finding answers.
How do I interpret the test results?
While your treating physician should review your results, we also offer a one-on-one test results review with our clinical team to help you understand what your results mean and what steps you can take next.
What is the cost of the test?
The price for this test includes standard shipping to you and return shipping to the lab, but local draw fees may apply. Ordering this test can help you address hormone-related symptoms sooner, which may help you feel better faster.
How often should I retest?
Retesting is usually recommended every 12 to 24 months, or sooner if your symptoms change or you start new hormone therapy. Regular testing helps track changes in your genetic and hormone profile, so you can adjust your care as needed.
How accurate is the test?
This test uses PCR-based DNA analysis for genetic markers, with a specificity of 99.8% and sensitivity of 99.5%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
READ: These tests are available for European countries only.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
Why Customers Trust True Health Labs - What People are saying
Also rated 4.6 out of 5 based on 3452 ShopperApproved reviews- See all TrueHealthLabs.com reviews.
