Ordering the Estrogen Metabolism Assessment, Serum | Canada
Ordering the Estrogen Metabolism Assessment, Serum helps measure how your body processes estrogen, which can affect symptoms like irregular periods, mood changes, and weight gain. This test checks two main estrogen breakdown products, giving clear information about hormone balance and possible risks for conditions like fibroids or breast cancer. Interestingly, research shows that the balance between 2-Hydroxyestrone and 16a-Hydroxyestrone can influence how estrogen acts in the body, which may impact long-term hormone-related risks.
When ordering this test, you can expect these specific benefits:
- Identifies if your estrogen is being broken down into forms linked to higher or lower risk for hormone-related conditions.
- Helps guide treatment for symptoms like hot flashes, night sweats, or PMS by showing your unique hormone patterns.
- Supports decisions about hormone therapy or supplements by providing measurable hormone breakdown data.
- Assists in monitoring changes after starting new treatments or lifestyle changes.
- Offers a clear picture of your estrogen metabolism, which can be important for those with a family history of hormone-sensitive cancers.
Who Should Consider Hormone Metabolite Testing
People who have been struggling with unexplained fatigue, mood swings, or changes in their menstrual cycle may find this test helpful, especially if other hormone tests have not given clear answers. For example, someone who has tried different treatments for persistent PMS or irregular periods but still has symptoms could use this test to find out if their body is processing estrogen in a way that contributes to these issues.
Ordering this test may also be useful in these situations:
- Experiencing new or worsening hot flashes or night sweats during menopause.
- Dealing with stubborn weight gain that does not improve with diet or exercise.
- Having a family history of breast, ovarian, or uterine cancer and wanting to check hormone-related risk factors.
- Managing conditions like endometriosis, fibroids, or unexplained infertility.
- Noticing increased hair loss or changes in skin health that may be linked to hormone shifts, even if other tests are normal.
This test gives measurable results about how your body breaks down estrogen, which can help target treatment for symptoms like mood changes, irregular cycles, or hormone-related weight gain. Delaying this test could mean missing the chance to adjust your care plan sooner, which may allow symptoms to continue or worsen.
Preparing for Hormone Breakdown Testing
Fasting is not required for this test, but always check the test kit instructions for any special steps before your blood draw. Make sure to follow any directions your doctor or healthcare provider gives you, as these can help ensure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Estrogen Metabolism Assessment, Serum
| Test Name | Reference Range | What This Biomarker Means | Low and High Levels of Estrogen Metabolism Assessment, Serum |
|---|---|---|---|
| 2-Hydroxyestrone | 0.4 – 3.0 | 2-Hydroxyestrone is a breakdown product of estrogen that is considered less active and may be linked to lower risk for hormone-sensitive cancers. It shows how your body processes estrogen into a form that is usually less stimulating to tissues. |
High levels mean your body is making more of the less active form of estrogen, which may lower certain risks.
Low levels mean your body is making less of this protective form, which could be linked to higher estrogen activity. |
| 16a-Hydroxyestrone | 0.2 – 1.2 | 16a-Hydroxyestrone is another estrogen breakdown product that is more active and can stimulate tissue growth. This marker helps show if your body is making more of the form linked to higher risk for hormone-driven conditions. |
High levels mean your body is making more of the active form, which may increase risk for hormone-sensitive conditions.
Low levels mean your body is making less of this stimulating form, which may lower certain risks. |
Reference ranges may change slightly as labs update their methods or as new research becomes available.
Estrogen Metabolism Assessment FAQ
Is there Estrogen Metabolism Assessment testing near me?
This is a test kit that can be collected at a local draw site; check the draw location link at the top of the page for options. For those dealing with symptoms like irregular periods or hormone-related weight changes, having a nearby collection site makes it easier to get tested quickly and start finding answers.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, but local draw fees may apply. Ordering this test is worth it if you want to address hormone-related symptoms sooner and get targeted support for issues like PMS, menopause, or unexplained weight gain.
How often should I retest?
Retesting is usually recommended every 6 to 12 months, especially if you are starting or changing hormone therapy, supplements, or lifestyle changes. Regular testing helps track how your estrogen metabolism responds to treatment and can guide adjustments for better results.
How accurate is the test?
This test uses high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) for precise measurement of estrogen metabolites, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
None.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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