Ordering the EndoSelect Salivary Hormones Test | Genova
The EndoSelect Salivary Hormones Test from Genova helps measure hormone levels throughout the day, giving a clear picture of patterns that may affect mood, energy, and reproductive health. This test uses saliva samples, which can show hormone changes that blood tests might miss, especially for hormones like cortisol that shift during the day. Interestingly, saliva testing can reveal how much active, unbound hormone is available in the body, which is often more useful than total hormone levels.
Ordering this test can help you:
- Track hormone changes at four different times in one day for a complete daily pattern.
- Spot imbalances linked to symptoms like hot flashes, night sweats, or low energy.
- Check for hormone shifts that may affect fertility or menstrual cycles.
- Monitor how stress affects your body by measuring cortisol at key times.
- Get a non-invasive, easy-to-collect sample at home without a blood draw.
Who Should Consider Hormone Imbalance Testing
People who have been feeling tired, moody, or have noticed changes in their hair, skin, or sleep may benefit from this test. For example, someone who has been struggling with sudden weight gain, trouble sleeping, and mood swings might find that checking their hormone levels helps explain these changes and guides their next steps.
Ordering this test may also be helpful if you:
- Have irregular periods or symptoms of menopause, like hot flashes or night sweats.
- Are experiencing unexplained hair loss or changes in skin texture.
- Have been trying to get pregnant without success and want to check hormone balance.
- Notice low sex drive or changes in sexual function.
- Have a family history of hormone-related conditions and want to check your own levels, even if you don’t have symptoms yet.
Checking your hormone levels can help you and your doctor find patterns that may be linked to symptoms like fatigue, mood changes, or trouble with periods or fertility. Delaying this test could mean missing early signs of hormone shifts that are easier to address when caught sooner.
Preparing for Salivary Hormone Collection
Fasting is not required for this test, but you should avoid eating, drinking, or brushing your teeth for at least 30 minutes before collecting each saliva sample. Always follow any instructions your healthcare provider gives you to make sure your samples are collected correctly and your results are as useful as possible.
Labs Included When Ordering Your EndoSelect Salivary Hormones Test
| Test Name | Reference Range | What This Test Shows | Low and High Levels of EndoSelect Salivary Hormones Test |
|---|---|---|---|
| Estrogen Markers | |||
| Estrone | 1.0 – 3.0 | Estrone is a type of estrogen important for reproductive health and bone strength. It helps regulate menstrual cycles and supports tissue growth. |
High levels mean possible estrogen dominance, which can cause heavy periods or breast tenderness.
Low levels mean possible menopause or low ovarian function. |
| Estradiol | 1.3 – 3.3 | Estradiol is the main estrogen in women of childbearing age. It affects mood, bone health, and menstrual cycles. |
High levels mean risk for symptoms like bloating, mood swings, or irregular cycles.
Low levels mean possible menopause, missed periods, or bone loss. |
| Estriol | 0.5 – 2.2 | Estriol is a weaker estrogen, mostly present during pregnancy. It helps with tissue repair and supports the urinary tract. |
High levels mean possible pregnancy or hormone therapy effects.
Low levels mean possible hormone deficiency or issues with estrogen production. |
| Other Hormones | |||
| Progesterone | 30 – 100 | Progesterone helps prepare the body for pregnancy and balances the effects of estrogen. It also supports sleep and mood stability. |
High levels mean possible pregnancy or hormone therapy.
Low levels mean possible trouble with ovulation or irregular cycles. |
| Testosterone | 30 – 110 | Testosterone supports muscle strength, energy, and sex drive in both men and women. It also helps with bone health and mood. |
High levels mean possible PCOS or excess hair growth.
Low levels mean possible fatigue, low sex drive, or muscle loss. |
| DHEA | 2.0 – 10.0 | DHEA is a hormone made by the adrenal glands. It helps make other hormones and supports energy, mood, and immune function. |
High levels mean possible adrenal overactivity or hormone imbalance.
Low levels mean possible adrenal fatigue or aging. |
| Cortisol (by Time of Day) | |||
| Cortisol, 7 am – 9 am | 3.7 – 9.5 | Cortisol is the main stress hormone. Morning levels should be highest to help you wake up and feel alert. |
High levels mean possible stress, sleep problems, or adrenal issues.
Low levels mean possible adrenal fatigue or trouble waking up. |
| Cortisol, 11 am – 1 pm | 1.2 – 3.0 | Cortisol should drop by midday. This helps keep energy steady and prevents feeling wired or anxious. |
High levels mean possible ongoing stress or anxiety.
Low levels mean possible low adrenal function or fatigue. |
| Cortisol, 3 pm – 5 pm | 0.6 – 1.9 | Afternoon cortisol should be lower, helping you wind down. This pattern supports restful sleep later on. |
High levels mean possible stress or trouble relaxing.
Low levels mean possible low adrenal output or afternoon tiredness. |
| Cortisol, 10 pm – 12 am | 0.4 – 1.0 | Nighttime cortisol should be lowest, allowing for deep sleep and recovery. High levels at night can disrupt sleep. |
High levels mean possible sleep problems or chronic stress.
Low levels mean possible healthy sleep pattern or low adrenal function. |
Reference ranges may change slightly as labs update their standards, so always check your report for the most current values.
EndoSelect Salivary Hormones Test FAQ
Is there EndoSelect Salivary Hormones Test testing near me?
This is a home test kit, so you can collect your saliva samples wherever you are most comfortable, and use the draw location link at the top of the page if you need help. For people with symptoms like fatigue or mood changes, being able to collect samples at home makes it easier to test at the right times of day without extra travel.
How do I interpret the test results?
While your treating doctor should help you understand your results, we also offer a one-on-one test results review with our clinical team for extra support.
What is the cost of the test?
The price you see includes shipping both to you and back to the lab, but local draw fees may apply. Ordering this test can help you find out if hormone changes are behind symptoms like hot flashes or trouble sleeping, so you can get answers sooner.
How often should I retest?
Retesting is usually recommended every 3 to 6 months, especially if you are starting a new treatment or your symptoms change. This helps track how your hormone levels respond over time and guides any needed adjustments.
How accurate is the test?
This test uses enzyme immunoassay (EIA) technology for saliva samples, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
None.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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