Ordering the ENDO+ | Hormone Test | Genova
Ordering the ENDO+ | Hormone Test | Genova helps measure a wide range of hormone levels, including thyroid, adrenal, melatonin, and sex hormones, as well as estrogen metabolism. This test can help pinpoint the source of symptoms like fatigue, mood changes, weight gain, or sleep problems by providing a detailed hormone profile. Interestingly, this test also checks for estrogen metabolism markers, which can help assess the risk for hormone-related cancers—something not included in many standard hormone panels.
When ordering this test, you gain access to several specific benefits:
- Measures thyroid, adrenal, and sex hormones in one comprehensive panel
- Assesses estrogen metabolism to help evaluate cancer risk
- Includes melatonin and cortisol to check for sleep and stress hormone patterns
- Provides results for both men and women, including those in menopause or with irregular cycles
- Uses multiple specimen types (saliva, urine, blood) for a complete hormone picture
Who Should Consider Comprehensive Hormone and Metabolism Testing
People who have been feeling tired, dealing with mood swings, or noticing changes in weight or sleep may benefit from this test. For example, someone who has tried different diets and exercise routines but still struggles with unexplained weight gain and low energy could use this test to check for hormone imbalances that might be affecting their metabolism.
Ordering this test may also be helpful in these situations:
- Experiencing hot flashes, night sweats, or other menopause symptoms
- Dealing with hair loss, acne, or changes in skin texture
- Having trouble with fertility or irregular menstrual cycles
- Feeling anxious, depressed, or having trouble sleeping
- Noticing changes in bone strength or muscle mass, which can be linked to hormone shifts
Testing can help identify hormone patterns that may be causing symptoms like fatigue, mood changes, or sleep problems, allowing for more targeted treatment. Delaying this test could mean missing early signs of hormone imbalances, which may make symptoms harder to manage over time.
How to Prepare for Hormone and Metabolism Lab Testing
Fasting is not required for this test, but you should follow the specific collection instructions provided in your kit for saliva, urine, and blood samples. Always go by the directions from your doctor or healthcare professional to make sure your samples are collected correctly and your results are as useful as possible.
Labs Included When Ordering Your ENDO+ | Hormone Test | Genova
| Test Name | Reference Range | What This Test Measures | Low and High Levels of This Marker |
|---|---|---|---|
| Salivary Hormones | |||
| Estrone (Saliva) | Men: 4–12 Women (premenopausal): 6–30 Women (postmenopausal): 2–10 |
Estrone is a type of estrogen that helps regulate reproductive and metabolic functions. It is especially important in postmenopausal women. |
High levels mean possible estrogen dominance, which can cause weight gain or increase cancer risk.
Low levels mean possible menopause symptoms or low estrogen production. |
| Estradiol (Saliva) | Men: 0.5–2.2 Women (premenopausal): 1.3–3.3 Women (postmenopausal): 0.5–1.7 |
Estradiol is the main estrogen in women of childbearing age and is key for menstrual cycles, bone health, and mood. |
High levels mean possible ovarian cysts or hormone therapy effects.
Low levels mean possible menopause, bone loss, or irregular cycles. |
| Estriol (Saliva) | Men: 0–0.5 Women (premenopausal): 0.5–2.2 Women (postmenopausal): 0–0.8 |
Estriol is a weaker estrogen, important in pregnancy and for balancing other estrogens. |
High levels mean possible pregnancy or hormone therapy effects.
Low levels mean possible low estrogen or menopause symptoms. |
| Progesterone (Saliva) | Men: 12–100 Women (luteal): 75–270 Women (follicular): 12–100 |
Progesterone helps balance estrogen and supports menstrual cycles, pregnancy, and sleep. |
High levels mean possible pregnancy or hormone therapy effects.
Low levels mean possible irregular cycles, PMS, or sleep problems. |
| Testosterone (Saliva) | Men: 100–350 Women: 10–55 |
Testosterone is important for muscle strength, energy, mood, and sex drive in both men and women. |
High levels mean possible PCOS in women or excess supplementation.
Low levels mean possible fatigue, low libido, or muscle loss. |
| DHEA (Saliva) | Men: 150–350 Women: 100–300 |
DHEA is a hormone made by the adrenal glands that helps make other hormones and supports energy and stress response. |
High levels mean possible adrenal overactivity or supplementation.
Low levels mean possible adrenal fatigue or chronic stress. |
| Serum Hormones | |||
| Estrone (Serum) | Men: 10–60 Women (premenopausal): 17–200 Women (postmenopausal): 7–40 |
Estrone in blood helps assess estrogen status, especially in postmenopausal women and men. |
High levels mean possible obesity, liver issues, or hormone therapy effects.
Low levels mean possible menopause or low estrogen production. |
| Estradiol (Serum) | Men: 10–40 Women (premenopausal): 30–400 Women (postmenopausal): 0–30 |
Estradiol in blood is the main estrogen for reproductive health, bone strength, and mood. |
High levels mean possible ovarian cysts, tumors, or hormone therapy effects.
Low levels mean possible menopause, bone loss, or irregular cycles. |
| Estriol (Serum) | Men: 0–0.5 Women (premenopausal): 0.5–2.2 Women (postmenopausal): 0–0.8 |
Estriol in blood is a weaker estrogen, important for pregnancy and balancing other estrogens. |
High levels mean possible pregnancy or hormone therapy effects.
Low levels mean possible low estrogen or menopause symptoms. |
| Progesterone (Serum) | Men: 0.1–1.0 Women (luteal): 5–20 Women (follicular): 0.1–1.5 |
Progesterone in blood supports menstrual cycles, pregnancy, and helps balance estrogen. |
High levels mean possible pregnancy or hormone therapy effects.
Low levels mean possible irregular cycles, PMS, or sleep problems. |
| Testosterone, Total (Serum) | Men: 300–1000 Women: 15–70 |
Total testosterone in blood is important for muscle, energy, mood, and sex drive in both men and women. |
High levels mean possible PCOS in women or excess supplementation.
Low levels mean possible fatigue, low libido, or muscle loss. |
| DHEA-S (Serum) | Men: 80–560 Women: 35–430 |
DHEA-S in blood is a marker of adrenal function and helps make other hormones. |
High levels mean possible adrenal overactivity or supplementation.
Low levels mean possible adrenal fatigue or chronic stress. |
| Sex Hormone Binding Globulin | Men: 10–57 Women: 18–144 |
SHBG binds to sex hormones and controls how much is available for the body to use. |
High levels mean less free testosterone or estrogen, which can affect energy and sex drive.
Low levels mean more free hormones, which can cause symptoms like acne or hair loss. |
| Urine Estrogens | |||
| Estrone (Urine) | Men: 4–12 Women (premenopausal): 6–30 Women (postmenopausal): 2–10 |
Estrone in urine helps show how the body is processing and clearing estrogen. |
High levels mean possible estrogen dominance or slow clearance.
Low levels mean possible low estrogen production or fast clearance. |
| Estradiol (Urine) | Men: 0.5–2.2 Women (premenopausal): 1.3–3.3 Women (postmenopausal): 0.5–1.7 |
Estradiol in urine helps check estrogen metabolism and balance. |
High levels mean possible hormone therapy effects or slow metabolism.
Low levels mean possible menopause or low estrogen. |
| Estriol (Urine) | Men: 0–0.5 Women (premenopausal): 0.5–2.2 Women (postmenopausal): 0–0.8 |
Estriol in urine is a marker for estrogen balance and pregnancy status. |
High levels mean possible pregnancy or hormone therapy effects.
Low levels mean possible low estrogen or menopause. |
| 2-Hydroxyestrone | Men: 0.5–2.2 Women: 1.3–3.3 |
2-Hydroxyestrone is a breakdown product of estrogen, linked to lower cancer risk when balanced. |
High levels mean possible increased estrogen breakdown.
Low levels mean possible slow estrogen metabolism. |
| 4-Hydroxyestrone | Men: 0.1–0.5 Women: 0.2–0.7 |
4-Hydroxyestrone is another estrogen breakdown product, and high levels may be linked to higher cancer risk. |
High levels mean possible increased cancer risk.
Low levels mean possible low estrogen metabolism. |
| 2-Methoxyestrone | Men: 0.2–0.8 Women: 0.3–1.2 |
2-Methoxyestrone is a protective estrogen metabolite, helping to lower cancer risk. |
High levels mean possible good estrogen metabolism.
Low levels mean possible higher risk for hormone-related cancers. |
| 4-Methoxyestrone | Men: 0.1–0.5 Women: 0.2–0.7 |
4-Methoxyestrone is another breakdown product, and helps show how the body processes estrogen. |
High levels mean possible good estrogen clearance.
Low levels mean possible slow estrogen metabolism. |
| 16-alpha-hydroxy-estrone | Men: 0.2–0.8 Women: 0.3–1.2 |
16-alpha-hydroxy-estrone is a metabolite linked to higher estrogen activity and possible increased cancer risk if elevated. |
High levels mean possible increased risk for hormone-related cancers.
Low levels mean possible low estrogen activity. |
| Thyroid Hormones | |||
| TSH | 0.4–4.0 | TSH is a hormone from the pituitary gland that tells the thyroid to make thyroid hormones, which control metabolism and energy. |
High levels mean possible underactive thyroid (hypothyroidism).
Low levels mean possible overactive thyroid (hyperthyroidism). |
| Free T3 | 2.3–4.2 | Free T3 is the active thyroid hormone that helps control energy, mood, and metabolism. |
High levels mean possible overactive thyroid.
Low levels mean possible underactive thyroid or conversion problems. |
| Free T4 | 0.8–1.8 | Free T4 is a thyroid hormone that helps regulate metabolism and is converted to T3 in the body. |
High levels mean possible overactive thyroid or hormone therapy effects.
Low levels mean possible underactive thyroid. |
| Anti-thyroglobulin antibodies | <4 | These antibodies can show if the immune system is attacking the thyroid, which can cause thyroid problems. |
High levels mean possible autoimmune thyroid disease.
Low levels mean no sign of thyroid autoimmunity. |
| Anti-TPO antibodies | <9 | These antibodies are another marker for autoimmune thyroid disease, like Hashimoto’s or Graves’ disease. |
High levels mean possible autoimmune thyroid disease.
Low levels mean no sign of thyroid autoimmunity. |
| Adrenocortex | |||
| Cortisol, Salivary x4 | Morning: 3.7–9.5 Noon: 1.2–3.0 Evening: 0.6–1.9 Night: 0.4–1.0 |
Cortisol is a stress hormone that follows a daily pattern, helping control energy, sleep, and stress response. |
High levels mean possible chronic stress or adrenal overactivity.
Low levels mean possible adrenal fatigue or low stress response. |
| DHEA, Salivary | Men: 150–350 Women: 100–300 |
DHEA in saliva is a marker for adrenal health and helps make other hormones. |
High levels mean possible adrenal overactivity or supplementation.
Low levels mean possible adrenal fatigue or chronic stress. |
| Melatonin | |||
| Melatonin (3 specimens) | Morning: 0.7–3.0 Afternoon: 0.2–1.0 Night: 10–50 |
Melatonin is a hormone that helps control sleep and wake cycles, measured at different times to check daily rhythm. |
High levels mean possible sleep disorders or supplement use.
Low levels mean possible trouble falling or staying asleep. |
Reference ranges may change slightly as labs update their standards, so always check your report for the most current values.
ENDO+ | Hormone Test | Genova FAQ
Is there ENDO+ | Hormone Test | Genova testing near me?
This is a test kit that you can collect at home or at a local draw site—check the draw location link at the top of the page for options near you. If you’re dealing with symptoms like fatigue or hormone changes, having a nearby collection site makes it easier to get your samples done quickly and start finding answers.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price you see for the test includes standard shipping to you and return shipping to the lab, but draw fees may apply. Ordering this test can help you find out if hormone imbalances are causing symptoms like fatigue or mood changes, so you can get the right support sooner.
How often should I retest?
Retesting is usually recommended every 6–12 months, or sooner if you start new treatments or your symptoms change. Regular testing helps track how your hormone levels respond to changes in treatment or lifestyle.
How accurate is the test?
This test uses advanced mass spectrometry and immunoassay methods for saliva, urine, and blood samples, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This kit cannot be mailed or collected in New York State.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
Why Customers Trust True Health Labs - What People are saying
Also rated 4.6 out of 5 based on 3452 ShopperApproved reviews- See all TrueHealthLabs.com reviews.
