Ordering the DUTCH Cycle Mapping PLUS Test
The DUTCH Cycle Mapping PLUS Test from Precision Analytical tracks hormone patterns throughout the menstrual cycle, providing a detailed look at estrogen, progesterone, and adrenal hormone changes. This test is especially helpful for those with irregular cycles, fertility concerns, or symptoms that change throughout the month. Interestingly, this test also measures the cortisol awakening response, which can reveal hidden stress patterns that may affect hormone balance.
Ordering this test gives you:
- A full map of estrogen and progesterone changes across your cycle
- Assessment of ovarian reserve and ovulation timing
- Insight into adrenal hormone production, including cortisol and cortisone
- Evaluation of hormone metabolites for a deeper look at hormone processing
- Measurement of melatonin and markers of oxidative stress
Who Should Consider Hormone Cycle and Adrenal Testing
People who experience unpredictable periods, mood swings, or unexplained fatigue may find this test helpful. For example, someone who feels energetic some weeks but struggles with low energy, headaches, or irritability at other times may benefit from seeing how their hormones shift throughout the month.
Ordering may also be helpful in these situations:
- Trying to conceive and wanting to confirm ovulation timing
- Experiencing hot flashes or night sweats before menopause
- Dealing with ongoing PMS symptoms that disrupt daily routines
- Noticing changes in hair growth or skin health that seem linked to your cycle
- Tracking hormone changes after stopping birth control, which can reveal how your body is adjusting
This test is recommended for those who want to pinpoint hormone imbalances, track ovulation, or understand how stress may be affecting their cycle. Delaying this test could mean missing the best window to catch hormone shifts that only show up at certain times in your cycle, making it harder to find answers.
Preparing for Comprehensive Hormone and Adrenal Testing
Fasting is not required for this test, but you will need to collect samples at specific times during your cycle for the most complete results. Always follow the instructions provided by your doctor or healthcare professional to make sure your samples are collected correctly and your results are as useful as possible.
Labs Included When Ordering Your DUTCH Cycle Mapping PLUS Test
| Test Name | Reference Range | Significance | Low and High Levels of DUTCH Cycle Mapping PLUS |
|---|---|---|---|
| Urinary Progesterone | Luteal: 2000-15000; Follicular: <500 | Progesterone supports ovulation and prepares the uterus for pregnancy. Tracking levels helps identify ovulation and luteal phase issues. | High levels mean possible ovarian cysts or hormone therapy effects.
Low levels mean possible ovulation problems or luteal phase defects. |
| Androgen | 100-400 | Androgens, like testosterone, affect energy, mood, and hair growth. They also play a role in reproductive health and muscle strength. | High levels mean possible polycystic ovary syndrome or adrenal issues.
Low levels mean possible fatigue, low libido, or muscle weakness. |
| Estrogen Metabolites | 16-80 | Estrogen metabolites show how your body processes estrogen. This helps identify risks for hormone-related symptoms and guides treatment. | High levels mean increased estrogen activity or slow metabolism.
Low levels mean reduced estrogen production or fast clearance. |
| Cortisol | Morning: 10-20; Night: 1-8 | Cortisol is a stress hormone that affects energy, sleep, and immune function. Measuring it helps identify stress-related hormone changes. | High levels mean chronic stress or adrenal overactivity.
Low levels mean adrenal fatigue or low stress response. |
| Cortisone | Morning: 20-50; Night: 5-15 | Cortisone is a form of cortisol that helps regulate inflammation and stress. It provides a fuller picture of adrenal function. | High levels mean increased adrenal activity or steroid use.
Low levels mean reduced adrenal output or conversion issues. |
| Cortisol Metabolites | 2000-6000 | These show how your body breaks down cortisol. They help spot hidden adrenal problems or stress patterns. | High levels mean increased cortisol breakdown or stress.
Low levels mean reduced cortisol production or slow metabolism. |
| Creatinine | 0.5-2.5 | Creatinine helps adjust hormone results for urine concentration. It ensures hormone levels are measured accurately. | High levels mean concentrated urine or kidney issues.
Low levels mean diluted urine or low muscle mass. |
| DHEA-S | 1000-4000 | DHEA-S is an adrenal hormone that supports mood, energy, and hormone balance. It also helps make other hormones. | High levels mean adrenal overactivity or PCOS.
Low levels mean adrenal fatigue or aging. |
| Vanilmandelate | 2-7 | Vanilmandelate is a breakdown product of adrenaline. It helps assess stress response and nervous system activity. | High levels mean increased stress or adrenal tumors.
Low levels mean low stress response or nervous system issues. |
| Homovanillate | 2-8 | Homovanillate is a dopamine breakdown product. It gives clues about mood, motivation, and nervous system health. | High levels mean increased dopamine activity or stress.
Low levels mean low dopamine or mood changes. |
| Kynurenate | 5-25 | Kynurenate is linked to vitamin B6 and brain function. It helps spot nutrient needs and nervous system changes. | High levels mean possible vitamin B6 deficiency or inflammation.
Low levels mean low tryptophan metabolism or nutrient issues. |
| Methylmalonate | 0.5-3.5 | Methylmalonate is a marker for vitamin B12 status. It helps detect early B12 deficiency. | High levels mean vitamin B12 deficiency.
Low levels mean normal B12 status. |
| Xanthurenate | 1-8 | Xanthurenate is related to vitamin B6 and tryptophan metabolism. It can show if your body needs more B6. | High levels mean vitamin B6 deficiency.
Low levels mean normal B6 metabolism. |
| Pyroglutamate | 10-40 | Pyroglutamate is linked to glutathione, an antioxidant. It helps spot oxidative stress and detox needs. | High levels mean increased oxidative stress or glutathione loss.
Low levels mean low glutathione or detox issues. |
| Quinolinate | 1-6 | Quinolinate is a marker for inflammation and brain health. It can show if your body is under stress or needs support. | High levels mean inflammation or brain stress.
Low levels mean normal inflammation control. |
| Indican | 0-10 | Indican shows how well your gut breaks down protein. It can help spot digestive or gut health issues. | High levels mean poor protein digestion or gut imbalance.
Low levels mean normal protein breakdown. |
| b-Hydroxyisovalerate | 0.5-2.5 | This marker is linked to biotin (vitamin B7) status. It helps spot biotin needs or metabolism issues. | High levels mean biotin deficiency.
Low levels mean normal biotin status. |
| 8-OHdG | 2-10 | 8-OHdG is a marker for DNA damage from oxidative stress. It helps spot cell stress and need for antioxidants. | High levels mean increased oxidative stress or cell damage.
Low levels mean low oxidative stress. |
| Melatonin (6-OHMS) | 10-60 | Melatonin helps regulate sleep and circadian rhythm. Measuring it can explain sleep problems or fatigue. | High levels mean increased melatonin production or supplement use.
Low levels mean sleep issues or low melatonin production. |
| Salivary Cortisol Awakening Response, Cortisol, Cortisone | CAR: 50-75% rise; Cortisol: 10-20; Cortisone: 20-50 | These markers show how your body responds to waking up and stress. They help spot adrenal fatigue or overactivity. | High levels mean high stress response or adrenal overactivity.
Low levels mean blunted stress response or adrenal fatigue. |
Reference ranges may change slightly as labs update their methods and guidelines. Always check your report for the most current reference values.
DUTCH Cycle Mapping PLUS FAQ
Is there DUTCH Cycle Mapping PLUS testing near me?
This is a home test kit, so you can collect your samples locally and send them to the lab using the included shipping materials. For those with unpredictable cycles or busy schedules, being able to collect samples at home makes it easier to track hormone changes without needing to visit a clinic.
How do I interpret the test results?
While your treating physician should review your results, we also offer a one-on-one test results review with our clinical team to help you understand your hormone patterns and next steps.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, though draw fees may apply. Ordering this test can help you find the cause of symptoms like irregular cycles or fatigue, so you can address them sooner.
How often should I retest?
Retesting is usually recommended every 6-12 months, or after any major changes in symptoms or treatment, to track hormone shifts and see how your body is responding.
How accurate is the test?
This test uses advanced dried urine and saliva collection with mass spectrometry and immunoassay methods, offering over 98% specificity and 97% sensitivity for hormone measurement. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test is available in the US (except New York and Maryland) and Canada. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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