Ordering the Direct Antiglobulin Test DAT (Coombs Direct) Test
Ordering the Direct Antiglobulin Test DAT (Coombs Direct) Test can help identify if your red blood cells are being attacked by your immune system. Interestingly, this test can also be used to check for hemolytic disease in newborns.
When ordering this test, consider the following benefits:
- Detects antibodies attached to red blood cells.
- Helps diagnose autoimmune hemolytic anemia.
- Assists in investigating transfusion reactions.
- Evaluates hemolytic disease of the newborn.
- Monitors certain drug-induced hemolytic anemias.
Who Should Consider the Test
People who experience unexplained fatigue or jaundice might find this test beneficial. For example, a person who recently had a blood transfusion and is feeling unusually tired may need this test to check for transfusion reactions.
Other scenarios where this test might be ordered include:
- Experiencing symptoms of anemia.
- Having a family history of autoimmune disorders.
- Newborns with jaundice.
- Monitoring after certain medications.
- Unexplained drop in hemoglobin levels.
Ordering this test can provide clarity on whether your immune system is affecting your red blood cells. Delaying this test might lead to prolonged symptoms or complications related to untreated hemolytic anemia.
How to Prepare for the Test
No fasting is required for the Direct Antiglobulin Test. It’s important to follow any instructions your healthcare provider gives you to ensure the test goes smoothly.
Labs Included When Ordering Your Direct Antiglobulin Test
| Test Name | Reference Ranges | Significance | Low and High Levels of Direct Antiglobulin Test |
|---|---|---|---|
| Direct Antiglobulin Test (DAT) (Coombs, Direct) | Negative | This test checks for antibodies attached to red blood cells, which can indicate autoimmune hemolytic anemia or other conditions. | High levels mean there are antibodies attached to red blood cells, suggesting an immune response.
Low levels mean no antibodies are detected, indicating normal red blood cell function. |
Lab reference values are subject to change. Refer to the Quest Diagnostics lab test directory for current ranges.
Direct Antiglobulin Test FAQ
Is there Antiglobulin testing near me?
To find nearby locations for Antiglobulin Test, use the patient service center locator. This is especially helpful if you need a convenient site due to mobility issues or require quick sample collection.
What is the cost of the test?
The cost of the Direct Antiglobulin Test includes all fees, such as sample collection at patient service centers. It’s worth ordering this test to address unexplained anemia symptoms.
How often should I retest?
Retesting is typically recommended if symptoms persist or if there are changes in your condition. Regular monitoring can help manage autoimmune hemolytic anemia effectively.
How accurate is the test?
The Direct Antiglobulin Test uses the Coombs method to detect antibodies on red blood cells, ensuring precise results. TrueHealthLabs.com partners with CLIA-certified laboratories to uphold rigorous testing standards for dependable results.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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