Ordering the DetoxiGenomic Profile | Genova
The DetoxiGenomic Profile from Genova Diagnostics helps you learn how your genes affect the way your body removes toxins and processes certain medications. This test looks at over 20 gene variations, called SNPs, that can change how your body handles chemicals, pollution, and other harmful substances. Interestingly, some people may not realize that these gene changes can also affect how their bodies respond to common household products or even foods.
Ordering this test can help you:
- Find out if your body has trouble clearing out toxins from the environment or food.
- See if you are more likely to react to certain medications or chemicals.
- Get information about your risk for problems like fatigue, headaches, or skin issues linked to toxin buildup.
- Learn if you need extra support for your liver or antioxidant systems.
- Receive guidance for a nutrition plan that matches your genetic needs.
Who Should Consider Genetic Detoxification Testing
People who often feel tired, have frequent headaches, or notice skin problems after being around cleaning products or pollution may benefit from this test. For example, someone who feels unusually drained after spending time in a city with high air pollution might find answers by checking their genetic detox pathways.
Ordering this test may also be helpful if you:
- Have ongoing digestive problems that do not improve with diet changes.
- Notice mood swings or trouble focusing after eating certain foods or taking medications.
- Experience unexplained weight gain despite regular exercise and balanced meals.
- Struggle with allergies or chemical sensitivities that seem to get worse over time.
- Have a family history of slow recovery from illnesses, which can sometimes be linked to genetic detox issues.
Testing for these gene changes can show if your body needs extra help to remove toxins, support your liver, or adjust your nutrition plan. Delaying this test could mean missing the chance to make changes that may help you feel better and avoid problems linked to toxin buildup.
Preparing for Genetic Detoxification Analysis
No fasting is needed for this genetic test, so you can eat and drink as usual before collecting your sample. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected the right way and your results are as helpful as possible.
Labs Included When Ordering Your DetoxiGenomic Profile | Genova
| Test Name | Reference Range | What This Test Measures | Low and High Levels of DetoxiGenomic Profile | Genova |
|---|---|---|---|
| Phase I: Cytochrome P-450 Enzymes | |||
| CYP1A1 | Wild type, Heterozygous, Homozygous variant | CYP1A1 helps break down toxins from smoke, pollution, and some foods. It also affects how your body handles certain hormones and medications. |
High levels mean your body may process toxins and some drugs faster, which can sometimes create more harmful byproducts.
Low levels mean slower toxin breakdown, which can lead to buildup of chemicals in your body. |
| CYP1B1 | Wild type, Heterozygous, Homozygous variant | CYP1B1 is involved in breaking down hormones and environmental toxins. It can also affect how your body handles estrogen. |
High levels mean increased breakdown of hormones, which may affect hormone balance.
Low levels mean slower removal of toxins and hormones, possibly leading to buildup. |
| CYP2A6 | Wild type, Heterozygous, Homozygous variant | CYP2A6 helps process nicotine and some medications. It also plays a role in breaking down certain toxins from the environment. |
High levels mean faster breakdown of nicotine and some drugs, which can affect how long they stay in your body.
Low levels mean slower processing, which can lead to higher levels of these substances in your system. |
| CYP2D6 | Wild type, Heterozygous, Homozygous variant | CYP2D6 is important for breaking down many medications and some toxins. It affects how your body responds to certain drugs. |
High levels mean you may process some medications too quickly, reducing their effect.
Low levels mean slower drug breakdown, which can increase side effects or toxicity. |
| CYP2E1 | Wild type, Heterozygous, Homozygous variant | CYP2E1 helps break down alcohol, smoke, and some chemicals. It can also create reactive byproducts that may cause cell damage. |
High levels mean more byproducts may be made, which can increase cell stress.
Low levels mean slower removal of alcohol and chemicals, leading to buildup. |
| CYP2C9 | Wild type, Heterozygous, Homozygous variant | CYP2C9 is involved in breaking down medications and some toxins. It affects how your body handles certain pain relievers and blood thinners. |
High levels mean faster drug breakdown, which can lower medication effects.
Low levels mean slower drug removal, which can increase risk of side effects. |
| CYP1C19 | Wild type, Heterozygous, Homozygous variant | CYP1C19 helps process certain medications and toxins. It can affect how your body responds to some heart and stomach medicines. |
High levels mean drugs may be cleared too quickly, reducing their benefit.
Low levels mean drugs may stay in your body longer, raising risk of side effects. |
| CYP3A4 | Wild type, Heterozygous, Homozygous variant | CYP3A4 is a key enzyme for breaking down many medications and toxins. It helps your body remove chemicals from food and the environment. |
High levels mean faster removal of drugs and toxins, which can lower drug effects.
Low levels mean slower clearance, which can increase buildup of substances. |
| Phase II: Conjugation and Elimination | |||
| COMT (Catechol-O-methyltransferase) | Wild type, Heterozygous, Homozygous variant | COMT helps break down stress hormones and some toxins. It also affects how your body handles certain brain chemicals. |
High levels mean faster breakdown of stress hormones, which can affect mood and focus.
Low levels mean slower removal, which can lead to higher stress hormone levels. |
| NAT1 (N-acetyl transferase 1) | Wild type, Heterozygous, Homozygous variant | NAT1 helps your body remove toxins from smoke, food, and the environment. It also affects how you process some medications. |
High levels mean faster toxin removal, which can sometimes create more byproducts.
Low levels mean slower detox, which can lead to buildup of harmful substances. |
| NAT2 (N-acetyl transferase 2) | Wild type, Heterozygous, Homozygous variant | NAT2 is important for breaking down chemicals from food, smoke, and some drugs. It helps your body get rid of certain toxins. |
High levels mean faster processing, which can sometimes increase risk of harmful byproducts.
Low levels mean slower removal, which can cause toxins to build up. |
| GSTM1 (Glutathione S-transferase M1) | Present, Null | GSTM1 helps your body use glutathione, a key antioxidant, to remove toxins. It protects cells from damage by chemicals and pollution. |
High levels mean strong antioxidant protection and better toxin removal.
Low levels mean less protection, which can increase risk of cell damage from toxins. |
| GSTP1 (Glutathione S-transferase P1) | Wild type, Heterozygous, Homozygous variant | GSTP1 helps your body use glutathione to remove toxins and protect against cell damage. It is important for handling pollution and chemicals. |
High levels mean better removal of toxins and stronger cell protection.
Low levels mean weaker detox and higher risk of cell stress. |
| Oxidative Protection | |||
| SOD1 (Superoxide Dismutase 1) | Wild type, Heterozygous, Homozygous variant | SOD1 helps protect your cells from damage by breaking down harmful molecules called free radicals. It is important for antioxidant defense. |
High levels mean strong protection against cell damage from free radicals.
Low levels mean weaker defense, which can increase risk of cell stress and damage. |
| SOD2 (Superoxide Dismutase 2) | Wild type, Heterozygous, Homozygous variant | SOD2 is another enzyme that protects your cells from free radical damage. It works mainly in the energy centers of your cells, called mitochondria. |
High levels mean better protection for your cells’ energy centers.
Low levels mean higher risk of cell stress and less energy production. |
Reference ranges may change slightly as labs update their methods and standards.
DetoxiGenomic Profile | Genova FAQ
Is there DetoxiGenomic Profile | Genova testing near me?
This is a test kit you can collect at home, and you can check the draw location link at the top of the page for local options. If you have ongoing fatigue or reactions to chemicals, having a nearby collection site makes it easier to get tested quickly and start finding answers.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for clear, personalized guidance.
What is the cost of the test?
The price you see includes standard shipping to you and back to the lab, but draw fees may apply. Ordering this test can help you address unexplained fatigue or chemical sensitivity sooner, so you can make changes that may help you feel better faster.
How often should I retest?
Retesting is usually recommended every 2-3 years, or if you have major changes in symptoms or exposure to new chemicals. This helps you track any changes in your genetic detox pathways and adjust your nutrition or support plan as needed.
How accurate is the test?
This test uses advanced DNA analysis with polymerase chain reaction (PCR) technology to detect gene variations, with specificity and sensitivity both above 99%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This kit cannot be mailed or collected in New York. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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