Ordering the Adrenocortex Stress Test | Genova Diagnostics
The Adrenocortex Stress Test from Genova Diagnostics helps measure how your adrenal glands respond to daily stress by tracking cortisol and DHEA levels throughout the day. This test can help pinpoint patterns of hormone imbalance that may be linked to symptoms like fatigue, mood changes, or trouble sleeping. Interestingly, research shows that irregular cortisol rhythms can affect immune function and even influence how the body handles inflammation.
Ordering this test can help you:
- Track cortisol changes at four points in a 24-hour period for a complete view of adrenal activity
- Measure DHEA, a hormone that works with cortisol to balance stress response
- Identify patterns that may be linked to sleep problems, low energy, or mood swings
- Support your doctor in making targeted recommendations for stress management
- Monitor how your body’s stress response changes over time with treatment or lifestyle changes
Who Should Consider Adrenal Hormone Testing
People who feel tired even after a full night’s sleep, notice frequent mood swings, or have trouble handling daily stress may benefit from this test. For example, someone who feels exhausted in the morning but wired at night could use this test to see if their cortisol levels are out of balance.
Ordering this test may also be helpful if you:
- Experience unexplained weight gain or loss despite no major changes in diet or activity
- Have trouble falling asleep or staying asleep, especially if you wake up feeling unrested
- Notice increased irritability or anxiety during stressful periods
- Struggle with frequent colds or slow recovery from illness
- Have a history of chronic inflammation or autoimmune issues, as stress hormones can impact immune response
Testing your adrenal hormones can help you and your doctor find out if hormone imbalances are linked to symptoms like fatigue, mood changes, or sleep problems. Delaying this test may make it harder to connect symptoms to hormone patterns, which could slow down finding the right support.
How to Prepare for the Test
No fasting is needed for this saliva-based test, but you will need to collect samples at specific times during the day. Make sure to carefully follow any instructions your doctor or healthcare provider gives you to get the most useful results.
Labs Included When Ordering Your Adrenocortex Stress Test | Genova Diagnostics
| Test Name | Reference Range | What This Measures | Low and High Levels of Adrenocortex Stress Test | Genova Diagnostics |
|---|---|---|---|
| Cortisol, Salivary (Morning) | 3.7 – 9.5 | Cortisol is a hormone made by the adrenal glands that helps the body respond to stress. Morning levels should be highest, showing your body is ready for the day. |
High levels mean your body may be under ongoing stress or inflammation.
Low levels mean your adrenal glands may not be making enough cortisol, which can cause tiredness or low energy. |
| Cortisol, Salivary (Noon) | 1.2 – 3.0 | This sample checks how quickly cortisol drops after waking. Levels should decrease by midday, showing a normal daily rhythm. |
High levels mean stress may be keeping your cortisol high longer than normal.
Low levels mean your body may not be keeping up with daily energy needs. |
| Cortisol, Salivary (Evening) | 0.6 – 1.9 | Evening cortisol should be lower, helping your body wind down for sleep. This sample shows if stress is affecting your ability to relax at night. |
High levels mean stress or late-day activity may be keeping you alert at night.
Low levels mean your body is winding down as expected. |
| Cortisol, Salivary (Night) | 0.4 – 1.0 | Nighttime cortisol should be at its lowest, allowing for restful sleep. This sample helps spot if stress is disrupting your sleep cycle. |
High levels mean your body may be staying in a stress state overnight.
Low levels mean your body is likely ready for sleep. |
| DHEA, Salivary | 2.0 – 10.0 | DHEA is a hormone that helps balance the effects of cortisol. It supports energy, mood, and immune function, and is measured once in this test. |
High levels mean your body may be making extra DHEA to balance stress.
Low levels mean your adrenal glands may be underactive or affected by long-term stress. |
Reference ranges may change slightly as labs update their methods or as new research becomes available.
Adrenocortex Stress Test | Genova Diagnostics FAQ
Is there Adrenocortex Stress Test | Genova Diagnostics testing near me?
This is a take-home saliva test kit, so you can collect your samples at home and use the draw location link to find a convenient drop-off site. For people dealing with ongoing fatigue or stress, being able to collect samples locally makes it easier to get tested without extra travel or waiting.
How do I interpret the test results?
While your treating doctor should review your results, you can also use our one-on-one test results review service for a detailed explanation from our clinical team.
What is the cost of the test?
The price you see includes standard shipping to your address and return shipping to the lab, but draw fees may apply. Ordering this test can help you find out if hormone imbalances are slowing your recovery from stress or fatigue.
How often should I retest?
It’s best to retest every 3 to 6 months, especially if you are making changes to your stress management plan or treatment. Regular testing helps track how your adrenal hormones respond to changes over time.
How accurate is the test?
This test uses enzyme immunoassay (EIA) to measure hormone levels in saliva, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
None.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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