Ordering the ADAMTS13 Activity with Reflex to Inhibitor Test
Ordering the ADAMTS13 Activity with Reflex to Inhibitor Test is crucial for diagnosing and managing certain blood disorders. This test measures the activity of the ADAMTS13 enzyme, which plays a key role in blood clotting. Interestingly, a deficiency in this enzyme can lead to a rare condition called thrombotic thrombocytopenic purpura (TTP), which can cause small blood clots to form throughout the body.
Here are some specific benefits of ordering this test:
- Helps diagnose TTP and other clotting disorders.
- Assists in monitoring treatment effectiveness for TTP.
- Provides insight into unexplained low platelet counts.
- Guides healthcare providers in making informed treatment decisions.
Who Should Consider This Lab Test
Individuals experiencing unexplained bruising or fatigue might benefit from this test. For example, someone who notices frequent nosebleeds and prolonged bleeding from minor cuts may find this test helpful in understanding their symptoms.
Consider these scenarios where this test might be relevant:
- Experiencing frequent headaches and dizziness.
- Having a family history of blood clotting disorders.
- Undergoing treatment for a known clotting disorder.
- Experiencing unexplained low platelet counts.
- Having a history of autoimmune diseases.
Ordering this test can provide valuable information about your blood clotting function. Without it, you might miss critical insights into your condition, potentially delaying effective treatment.
Preparing for Your Lab Test
Fasting is not required for this test. It’s important to follow your doctor’s instructions regarding any medications or supplements you are taking.
Labs Included When Ordering Your ADAMTS13 Activity with Reflex to Inhibitor Test
| Test Name | Reference Range | Significance | Low and High Levels of ADAMTS13 |
|---|---|---|---|
| ADAMTS13 Activity | 68-163 | This test measures the activity of the ADAMTS13 enzyme, which is crucial for breaking down von Willebrand factor. Low activity can lead to excessive clotting. | High levels mean increased risk of bleeding disorders.
Low levels mean potential for clotting disorders like TTP. |
| ADAMTS13 Inhibitor | < 0.4 | This test detects inhibitors that block ADAMTS13 activity, which can lead to clotting issues. It’s essential for diagnosing acquired TTP. | High levels mean presence of inhibitors affecting enzyme activity.
Low levels mean normal enzyme function. |
Reference ranges can vary. For the most current information, please visit the Quest Diagnostics lab test directory.
ADAMTS13 Activity with Reflex to Inhibitor Test FAQ
Is there ADAMTS13 Activity with Reflex to Inhibitor Test testing near me?
You can find nearby draw locations using our patient service center locator, which also offers mobile phlebotomy options. During the collection, a skilled technician will guide you through the process, ensuring a smooth and comfortable experience.
What is the cost of the test?
The cost of the ADAMTS13 Activity with Reflex to Inhibitor Test is listed at the top of the page. Pricing includes collection fees at patient service centers, ensuring transparency with no hidden costs.
How often should I retest?
Retesting is typically recommended every 6 to 12 months, depending on your condition and treatment plan. Regular monitoring can help track changes in enzyme activity and guide treatment adjustments.
How accurate is the test?
The test uses a chromogenic assay method to measure enzyme activity, providing precise results. TrueHealthLabs.com partners exclusively with CLIA-certified labs to ensure the highest standards of accuracy and reliability.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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