Ordering the Zonulin Stool Test by Doctor’s Data
The Zonulin Stool Test by Doctor’s Data helps measure zonulin, a protein that controls the tightness of the gut wall. This test is often ordered to check for increased intestinal permeability, sometimes called “leaky gut,” which can be linked to digestive problems, food sensitivities, and certain autoimmune conditions. Interestingly, zonulin is the only known regulator of intestinal tight junctions that can be measured in stool, making this test unique for those looking to understand gut barrier function.
Ordering the Zonulin Stool Test can provide specific benefits:
- Detects early changes in gut barrier function before symptoms become severe
- Helps identify possible triggers for digestive discomfort, such as gluten sensitivity
- Supports targeted treatment plans for gut-related autoimmune issues
- Monitors the effectiveness of dietary or lifestyle changes on gut health
- Offers a non-invasive way to assess intestinal permeability
Who Should Consider Gut Barrier and Intestinal Permeability Testing
People who experience ongoing digestive issues, unexplained fatigue, or skin rashes may benefit from this test. For example, someone who has tried multiple diets and supplements for bloating and brain fog, but still struggles with symptoms, may find answers through this type of testing.
Ordering this test may also be helpful in these situations:
- Persistent bloating, gas, or abdominal pain that does not improve with common remedies
- Unexplained nutrient deficiencies despite a balanced diet
- Chronic joint pain or inflammation without a clear cause
- Frequent mood swings or anxiety that seem linked to digestive changes
- Someone with a family history of autoimmune disease who wants to check for early gut changes
Testing for zonulin levels can help pinpoint if the gut wall is letting larger particles through, which may lead to inflammation, food reactions, or immune system changes. Delaying this test could mean missing the chance to address gut permeability before it leads to more complex symptoms or harder-to-manage conditions. To move forward, consider ordering the test to get clear answers about your gut barrier.
How to Prepare for the Test
No fasting is required for the Zonulin Stool Test, but you should follow the collection instructions provided in your test kit. Always go by any directions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Zonulin Stool Test
| Test Name | Reference Range | What This Marker Means | Low and High Levels of Zonulin |
|---|---|---|---|
| Zonulin | Less than 61 | Zonulin is a protein that controls how tightly the cells in your gut wall are joined together. High levels can mean the gut wall is letting larger particles through, which may trigger immune reactions or inflammation. |
High levels mean the gut barrier may be more open than normal, which can allow unwanted substances to pass into the body.
Low levels mean the gut wall is likely staying tightly sealed, which is usually a sign of normal gut function. |
Reference ranges may change slightly as labs update their methods and guidelines.
Zonulin Stool Test FAQ
Is there Zonulin Stool Test testing near me?
This is a mailed test kit, so you can collect your stool sample at home and send it back to the lab. For those dealing with ongoing digestive discomfort, being able to collect your sample privately and conveniently can make the process less stressful and more accessible—check the draw location link at the top of the page for more details.
How do I interpret the test results?
While your treating physician should review your results, we also offer a one-on-one test results review with our clinical team to help you understand what your numbers mean and what steps you can take next.
What is the cost of the test?
The price you see for the Zonulin Stool Test includes standard shipping to your address and return shipping to the lab, though draw fees may apply. Ordering this test can help you address gut permeability issues sooner, which may speed up your recovery from symptoms like bloating or food reactions.
How often should I retest?
It is generally recommended to retest every 3 to 6 months if you are making changes to your diet or treatment plan, or if your symptoms change. Regular retesting helps track improvements in gut barrier function and guides your next steps.
How accurate is the test?
The Zonulin Stool Test uses an enzyme-linked immunosorbent assay (ELISA) method, which is highly specific for detecting zonulin in stool samples. The test has a specificity of 98% and a sensitivity of 96%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- If you are taking antifungal or antibiotic medications, please finish the course of medication, and then wait three days before starting this collection. Please refrain from taking digestive enzymes, antacids, and aspirin for two days prior to and during the specimen collection, unless otherwise instructed by your physician. Never discontinue prescription medications without first consulting your physician.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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