Ordering the Trypsinogen Test
The Trypsinogen Test helps check how well the pancreas is working by measuring the amount of trypsinogen, a protein made by the pancreas, in the blood. This test is often used to help find problems like chronic pancreatitis, cystic fibrosis, or other issues that affect digestion and nutrient absorption. Interestingly, trypsinogen levels can also help spot enzyme deficiencies before symptoms become severe, which can help with early support and treatment.
Ordering the Trypsinogen Test can provide:
- Clear information about pancreatic function and enzyme production
- Early detection of digestive enzyme deficiencies
- Support for diagnosing cystic fibrosis in children and adults
- Help in monitoring chronic pancreatitis or other pancreatic conditions
- Guidance for next steps if you have unexplained digestive symptoms
Who Should Consider Pancreatic Enzyme Testing
People who have ongoing stomach pain, bloating, or trouble digesting food may benefit from this test. For example, a parent may notice their child is not gaining weight as expected, has frequent diarrhea, and seems to have greasy stools, which could point to a problem with the pancreas.
Ordering this test may also be helpful in these situations:
- Someone with a family history of cystic fibrosis or pancreatic disease
- Anyone with unexplained vitamin deficiencies, especially fat-soluble vitamins
- People who have frequent lung infections or a chronic cough
- Those with a history of gallstones and new digestive symptoms
- Children who have salty skin and frequent respiratory issues, which can sometimes be linked to cystic fibrosis
Testing for trypsinogen can help pinpoint the cause of symptoms like diarrhea, weight loss, or poor growth by showing if the pancreas is making enough enzymes. Delaying this test could mean missing early signs of pancreatic problems, which may lead to more severe symptoms or complications that are harder to manage later.
Preparing for Pancreatic Function Blood Testing
Fasting is not needed before this test, so you can eat and drink as usual unless your doctor gives you other instructions. Always follow any directions from your healthcare provider to make sure your sample is collected correctly and your results are as helpful as possible.
Labs Included When Ordering Your Trypsinogen Test
| Test Name | Reference Range | What This Marker Means | Low and High Levels of Trypsinogen |
|---|---|---|---|
| Trypsinogen | 20–40 | Trypsinogen is a protein made by the pancreas and released into the blood. It helps show if the pancreas is making enough digestive enzymes. |
High levels mean the pancreas may be inflamed or blocked, which can happen in acute pancreatitis or cystic fibrosis.
Low levels mean the pancreas may not be making enough enzymes, which can lead to trouble digesting food and absorbing nutrients. |
Reference ranges may change slightly as labs update their methods or as new research becomes available.
Trypsinogen Test FAQ
Is there Trypsinogen testing near me?
This test is available as a kit that you can take to a local draw site—check the draw location link for options near you. For people with ongoing digestive issues or children with possible cystic fibrosis, having a nearby collection site makes it easier to get tested quickly and start finding answers.
How do I interpret the test results?
While your doctor should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price you see for the Trypsinogen Test includes standard shipping to your home and back to the lab, but local draw fees may apply. Ordering this test can help you find out if your symptoms are related to a pancreatic enzyme problem, which can help you get the right treatment sooner.
How often should I retest?
Retesting is usually recommended every 6 to 12 months if you have a known pancreatic condition or ongoing symptoms, or sooner if your doctor suggests it. Regular testing helps track changes in enzyme levels and can show if your treatment plan is working.
How accurate is the test?
The Trypsinogen Test uses an immunoassay method, which is highly specific for detecting trypsinogen in blood samples, with a sensitivity of 98% and specificity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test is not available in NY, NJ, MA, and RI. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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