Ordering the Tissue Transglutaminase (tTG), IgA + IgG Test
Ordering the Tissue Transglutaminase (tTG), IgA + IgG test helps detect antibodies that may signal celiac disease or gluten-related conditions. This test measures both IgA and IgG antibodies, which can help identify immune reactions even in people with low IgA levels. Interestingly, some people with celiac disease may have normal IgA but elevated IgG, making this combined test more informative than testing for IgA alone.
When ordering this test, you can expect several specific benefits:
- Detects both common and less common immune responses to gluten.
- Helps confirm or rule out celiac disease in people with low IgA levels.
- Supports diagnosis in people with unexplained digestive symptoms.
- Assists in monitoring response to a gluten-free diet.
- Provides information for those with a family history of celiac disease.
Who Might Benefit from Gluten Antibody Screening
People who experience ongoing stomach pain, bloating, or diarrhea after eating foods with wheat or barley may benefit from this test. For example, someone who has tried removing gluten from their meals but still feels unwell might want to know if their body is reacting to gluten in a way that points to celiac disease.
Ordering this test may also be helpful in these situations:
- Someone with a family member diagnosed with celiac disease.
- People with type 1 diabetes or other autoimmune conditions.
- Children who are not growing as expected or have delayed puberty.
- Adults with unexplained iron deficiency anemia.
- People with skin rashes like dermatitis herpetiformis, which can be linked to gluten reactions.
This test can help pinpoint the cause of ongoing digestive problems, unexplained nutrient deficiencies, or certain skin conditions by checking for specific antibodies. Delaying this test could mean missing early signs of celiac disease, which may lead to more severe symptoms or complications over time. To move forward, consider ordering the test to get clear answers about gluten sensitivity.
Preparing for Gluten Antibody Blood Testing
Fasting is not required for the Tissue Transglutaminase (tTG), IgA + IgG test, so you can eat and drink as usual before your blood draw. Always follow any instructions your doctor or healthcare provider gives you to make sure your results are as helpful as possible.
Labs Included When Ordering Your Tissue Transglutaminase (tTG), IgA + IgG Test
| Test Name | Reference Range | What This Biomarker Shows | Low and High Levels of Tissue Transglutaminase (tTG), IgA + IgG |
|---|---|---|---|
| Tissue Transglutaminase (tTG) Antibody, IgA | Less than 4.0 | This marker checks for IgA antibodies against tissue transglutaminase, which are often present in people with celiac disease. It helps identify immune reactions to gluten in the digestive system. |
High levels mean your immune system is likely reacting to gluten, which may suggest celiac disease or gluten sensitivity.
Low levels mean there is little or no immune response to gluten, making celiac disease less likely. |
| Tissue Transglutaminase (tTG) Antibody, IgG | Less than 6.0 | This test measures IgG antibodies to tissue transglutaminase, which can be useful for people with low IgA or certain immune conditions. It helps catch cases that might be missed by IgA testing alone. |
High levels mean your body may be reacting to gluten, especially if IgA is low or missing, which can point to celiac disease.
Low levels mean there is little or no IgG immune response to gluten, making celiac disease less likely. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Tissue Transglutaminase FAQ
Is there Tissue Transglutaminase testing near me?
You can find nearby locations for Tissue Transglutaminase testing using the patient service center locator, which also lists mobile phlebotomy options for added convenience. This is especially helpful if you need quick access to testing due to ongoing digestive symptoms or want to avoid long travel for sample collection.
What is the cost of the test?
The price for this test includes all fees, such as sample collection at patient service center locations. Ordering this test is worthwhile if you have unexplained digestive issues and want clear answers about gluten reactions.
How often should I retest?
Retesting is usually recommended every 6 to 12 months if you are monitoring celiac disease or checking your response to a gluten-free diet. Regular testing helps track changes in antibody levels and shows if your dietary changes are working.
How accurate is the test?
This test uses enzyme-linked immunosorbent assay (ELISA) to measure IgA and IgG antibodies, with a sensitivity of about 98% and specificity of 95% for celiac disease. All tests at TrueHealthLabs.com are performed by CLIA-certified labs, meeting strict quality and precision standards.
Important Notes
Reference ranges may differ. Visit the Quest Diagnostics lab test directory for the latest values.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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