Ordering the Th1 Th2 Th17 Cytokine Test | Advanced
Ordering the Th1 Th2 Th17 Cytokine Test | Advanced helps pinpoint specific immune system imbalances by measuring cytokines, which are proteins that guide immune responses. This test is often used to help clarify the immune profile in people with autoimmune, inflammatory, or chronic conditions, supporting more targeted treatment plans. Interestingly, cytokine patterns can sometimes reveal immune shifts before symptoms become obvious, offering a window for early intervention.
When ordering this test, you gain:
- Detailed measurement of Th1, Th2, and Th17 cytokines to identify immune dominance or imbalance
- Insight into inflammatory and anti-inflammatory activity for more precise treatment adjustments
- Support for monitoring immune changes in response to therapies or lifestyle changes
- Guidance for selecting supplements or botanicals that may help balance immune function
- Data to help distinguish between different types of immune-driven conditions
Who Should Consider Immune Cytokine Panel Testing
People who have ongoing joint pain, skin rashes, or digestive issues that have not improved with standard care may benefit from this test. For example, someone with persistent fatigue and unexplained muscle aches, despite normal routine blood work, could use this test to uncover hidden immune imbalances that might be contributing to their symptoms.
Ordering this test may also be helpful in these situations:
- Chronic skin conditions like eczema or psoriasis that flare up without clear triggers
- Digestive discomfort or bloating that persists even after dietary changes
- Autoimmune thyroid issues, such as Hashimoto’s or Graves’ disease, with fluctuating symptoms
- Joint stiffness or swelling that comes and goes, especially if standard arthritis tests are negative
- People exposed to mold who develop new allergies or sensitivities, as mold can shift cytokine balance in unexpected ways
This test is recommended for those who want to track immune system changes over time, especially when symptoms are unclear or overlap with several conditions. Delaying this test could mean missing early signs of immune shifts, which may make it harder to adjust treatment plans before symptoms become more severe.
Preparing for Immune System Cytokine Analysis
Fasting is not required for this test, so you can eat and drink as usual before your blood draw. Make sure to follow any specific instructions your doctor or healthcare provider gives you, as these may help ensure your sample is collected and processed correctly.
Labs Included When Ordering Your Th1 Th2 Th17 Cytokine Test | Advanced
| Test Name | Reference Range | Significance | Low and High Levels of Th1 Th2 Th17 Cytokine Test | Advanced |
|---|---|---|---|
| Th1 Cytokines | |||
| INF Gamma | 7.0 – 20.0 | INF Gamma is a key Th1 cytokine that activates immune cells to fight infections and regulate inflammation. It helps defend against viruses and some bacteria. |
High levels mean the immune system is in an active Th1 state, which may be linked to autoimmune activity or chronic inflammation.
Low levels mean reduced Th1 response, which can make it harder to fight certain infections. |
| IL-1 beta | 0.0 – 5.0 | IL-1 beta is a pro-inflammatory cytokine that signals the immune system to respond to injury or infection. It is often elevated in chronic inflammation. |
High levels mean ongoing inflammation, which may be seen in autoimmune or inflammatory conditions.
Low levels mean less inflammatory signaling, which may reduce immune response to threats. |
| IL-2 | 2.0 – 10.0 | IL-2 helps T-cells grow and multiply, supporting immune defense and regulation. It is important for immune memory and response. |
High levels mean increased T-cell activity, which may be linked to autoimmunity.
Low levels mean weaker immune cell growth, which can affect immune defense. |
| IL-6 | 0.0 – 7.0 | IL-6 is produced by both Th1 and Th2 cells and is involved in inflammation and infection response. It can also affect metabolism and tissue repair. |
High levels mean active inflammation, often seen in autoimmune or chronic inflammatory conditions.
Low levels mean less inflammatory activity, which may slow healing or immune response. |
| IL-7 | 1.0 – 10.0 | IL-7 supports the development and survival of T-cells, helping maintain immune readiness. It is a weak Th1 cytokine. |
High levels mean increased T-cell production, which may be seen in immune activation.
Low levels mean reduced T-cell support, which can weaken immune defense. |
| IL-8 | 0.0 – 15.0 | IL-8 attracts white blood cells to sites of infection or injury. It is a weak Th1 cytokine and helps with inflammation control. |
High levels mean active recruitment of immune cells, often seen in ongoing inflammation.
Low levels mean less immune cell movement, which may slow response to infection. |
| IL-12 p70 | 0.0 – 5.0 | IL-12 p70 helps drive Th1 immune responses and supports defense against viruses and bacteria. It is important for immune balance. |
High levels mean strong Th1 activity, which may be linked to autoimmunity.
Low levels mean weaker Th1 response, which can affect infection control. |
| IL-17A | 0.0 – 3.0 | IL-17A is a Th17 cytokine that promotes inflammation and helps defend against bacteria and fungi. It is often elevated in autoimmune diseases. |
High levels mean increased Th17 activity, which may drive autoimmune or inflammatory conditions.
Low levels mean less Th17 response, which can reduce defense against certain infections. |
| IL-18 | 0.0 – 5.0 | IL-18 is a weak Th1 cytokine that helps boost immune cell activity and inflammation. It works with other cytokines to regulate immune responses. |
High levels mean increased inflammation, which may be seen in chronic immune activation.
Low levels mean less immune activation, which can affect response to infection. |
| TNF alpha | 0.0 – 8.0 | TNF alpha is a Th1 cytokine that drives inflammation and helps control infections. It is often targeted in autoimmune disease treatments. |
High levels mean active inflammation, which may be linked to autoimmune or chronic inflammatory conditions.
Low levels mean less inflammatory signaling, which may reduce immune defense. |
| Th2 Cytokines | |||
| IL-4 | 0.0 – 5.0 | IL-4 is a Th2 cytokine that helps produce antibodies and supports allergic responses. It balances Th1 activity and can affect allergy risk. |
High levels mean increased Th2 activity, which may be linked to allergies or asthma.
Low levels mean less antibody production, which can affect immune memory. |
| IL-5 | 0.0 – 5.0 | IL-5 is a Th2 cytokine that helps control eosinophils, a type of white blood cell involved in allergies and asthma. It supports immune defense against parasites. |
High levels mean increased allergy or asthma risk.
Low levels mean reduced eosinophil activity, which can affect parasite defense. |
| IL-10 | 1.0 – 10.0 | IL-10 is made by T-regulatory cells and helps calm inflammation. It keeps the immune system from overreacting and causing tissue damage. |
High levels mean strong anti-inflammatory activity, which may suppress immune responses.
Low levels mean less control over inflammation, which can lead to tissue damage. |
| IL-13 | 0.0 – 5.0 | IL-13 is a Th2 cytokine that helps with antibody production and allergic responses. It is often elevated in asthma and allergies. |
High levels mean increased allergy or asthma risk.
Low levels mean less antibody support, which can affect immune memory. |
| IL-15 | 0.0 – 5.0 | IL-15 is a weak Th2 cytokine that helps support the growth and survival of certain immune cells. It plays a role in immune memory and response. |
High levels mean increased immune cell activity, which may be seen in chronic immune activation.
Low levels mean reduced immune cell support, which can weaken immune response. |
Reference ranges may change slightly as labs update their standards, so always check your report for the most current values.
Th1 Th2 Th17 Cytokine Test | Advanced FAQ
Is there Th1 Th2 Th17 Cytokine Test | Advanced testing near me?
This test is provided as a kit that can be collected at a local draw site—check the draw location link at the top of the page. For people with ongoing symptoms like joint pain or skin rashes, having a nearby collection site makes it easier to get tested without extra travel or delays.
How do I interpret the test results?
While your treating physician should always review your results, we also offer a one-on-one test results review with our clinical team to help you understand your cytokine patterns and what they may mean for your care.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, though draw fees may apply at your local collection site. Ordering this test can help you and your provider identify immune imbalances that may be slowing your progress, so you can adjust your plan sooner.
How often should I retest?
Retesting is usually recommended every 3 to 6 months, especially if you are starting a new treatment or your symptoms are changing. Regular testing helps track immune shifts and allows for timely adjustments to your care plan.
How accurate is the test?
This test uses multiplex immunoassay technology, which measures multiple cytokines in a single blood sample with high precision. The specificity is 98% and sensitivity is 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- The test can be collected and mailed from New York state. Contact us with questions
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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