Ordering the MCAS Panel Suggested by Dr. Jill Carnahan
Ordering the MCAS Panel Suggested by Dr. Jill Carnahan helps identify markers linked to mast cell activation, allergic reactions, and immune system imbalances. This panel measures a range of biomarkers, including tryptase, chromogranin A, and cytokines, which can help clarify unexplained symptoms like flushing, hives, or digestive discomfort. Interestingly, some people with chronic sinus issues or recurring headaches may have underlying mast cell activation that standard allergy tests do not detect.
When ordering this panel, you gain access to specific benefits:
- Detects hidden triggers of allergic symptoms and inflammation.
- Measures both immediate and delayed immune responses, including total IgE and IgG.
- Assesses stress hormone levels, such as AM cortisol, that may influence immune activity.
- Identifies heavy metal exposure, which can worsen mast cell activation.
- Provides a comprehensive food allergy and intolerance profile for targeted dietary changes.
Who Might Benefit from Mast Cell Activation Screening
People who experience frequent skin rashes, unexplained digestive issues, or persistent fatigue may find answers through this panel. For example, someone who has tried multiple allergy medications without relief and continues to have unpredictable symptoms could benefit from a deeper look at immune and mast cell markers.
Ordering this panel may also be helpful in these situations:
- Recurring hives or swelling that do not respond to standard treatments
- Chronic sinus congestion or headaches with no clear cause
- Digestive discomfort, such as bloating or diarrhea, that persists despite dietary changes
- Unexplained flushing, rapid heartbeat, or dizziness after eating certain foods
- People with a family history of autoimmune or allergic conditions who want to understand their own risk
Testing for these markers can help pinpoint the source of symptoms, guide targeted treatment, and track changes over time. Delaying this panel may result in ongoing symptoms and missed opportunities to address triggers before they become more difficult to manage. Consider ordering if you want measurable answers to persistent symptoms.
Preparing for Mast Cell and Immune Marker Testing
Fasting is not required for this panel, but some tests may need to be collected at a specific time, such as morning cortisol. Always follow any instructions your doctor or healthcare provider gives you to make sure your results are as useful as possible.
Labs Included When Ordering Your MCAS Panel Suggested by Dr. Jill Carnahan
| Test Name | Reference Range | What This Biomarker Shows | Low and High Levels of This Marker |
|---|---|---|---|
| Chromogranin A | < 95 ng/mL | Chromogranin A is a protein released from neuroendocrine cells and mast cells. It helps detect abnormal cell activity and inflammation in the body. |
High levels mean possible mast cell activation, neuroendocrine tumors, or chronic inflammation.
Low levels mean reduced neuroendocrine activity or may be seen after certain treatments. |
| AM Cortisol | 6-18 mcg/dL (morning) | AM cortisol measures the main stress hormone in the morning. It helps assess adrenal function and how stress may affect immune responses. |
High levels mean increased stress response or possible adrenal overactivity.
Low levels mean possible adrenal fatigue or underactive adrenal glands. |
| Catecholamines, Fractionated Plasma | Epinephrine: 0-50 pg/mL Norepinephrine: 80-520 pg/mL Dopamine: 0-20 pg/mL |
Catecholamines are stress-related hormones. Measuring them helps identify abnormal stress responses and their effect on mast cell activity. |
High levels mean increased stress, possible tumors, or overactive nervous system.
Low levels mean reduced stress response or possible nervous system issues. |
| Heavy Metals Comprehensive Panel | Lead: < 5 µg/dL Mercury: < 10 µg/L Arsenic: < 35 µg/L |
This panel checks for toxic metals that can worsen immune and mast cell reactions. It helps identify hidden exposures that may trigger symptoms. |
High levels mean toxic metal exposure, which can worsen allergic and immune symptoms.
Low levels mean minimal or no exposure to these metals. |
| Total IgE | < 100 IU/mL | Total IgE, or immunoglobulin E, is an antibody linked to allergic reactions. It helps detect allergies and immune overactivity. |
High levels mean increased allergic response or possible parasitic infection.
Low levels mean low likelihood of allergies or immune overactivity. |
| Total IgG | 700-1600 mg/dL | Total IgG, or immunoglobulin G, is the most common antibody in blood. It shows how well the body can fight infections and respond to triggers. |
High levels mean chronic infection, inflammation, or immune system overactivity.
Low levels mean possible immune deficiency or reduced ability to fight infections. |
| IgE Antibody (Anti-IgE IgG) | Negative | This test checks for antibodies against IgE, which can affect allergic reactions. It helps clarify complex immune responses. |
High levels mean possible immune system imbalance or ongoing allergic response.
Low levels mean less likelihood of immune system targeting IgE. |
| Tryptase | < 11.5 ng/mL | Tryptase is an enzyme released by mast cells. It is a key marker for mast cell activation and related disorders. |
High levels mean active mast cell release, possible mast cell disorder, or allergic reaction.
Low levels mean no current mast cell activation. |
| Food allergy profile | Negative | This profile screens for common food allergies by measuring specific antibodies. It helps identify foods that may trigger symptoms. |
High levels mean likely food allergy or sensitivity to tested foods.
Low levels mean low risk of food allergy to tested items. |
| Food Intolerance Panel IgG | Negative | This panel measures delayed immune reactions to foods by checking IgG antibodies. It helps find foods that may cause ongoing symptoms. |
High levels mean possible delayed food intolerance or sensitivity.
Low levels mean low likelihood of delayed food reactions. |
| Tumor Necrosis Factor-Alpha | < 8.1 pg/mL | Tumor necrosis factor-alpha is a protein involved in inflammation. It helps show if there is ongoing immune activation or inflammation. |
High levels mean active inflammation or immune system activation.
Low levels mean little or no inflammation present. |
| Interleukin-6 | < 5.0 pg/mL | Interleukin-6 is a cytokine that rises with inflammation and immune system activity. It helps track immune responses and inflammation levels. |
High levels mean increased inflammation or immune response.
Low levels mean little or no immune activation. |
| Interleukin-1 Beta | < 5.0 pg/mL | Interleukin-1 beta is another cytokine linked to inflammation. It helps identify immune system activation and possible allergic reactions. |
High levels mean active inflammation or immune response.
Low levels mean little or no immune activation. |
| Prostaglandin D2 URINE | < 2,000 pg/mg creatinine | Prostaglandin D2 is a chemical released by mast cells. Measuring it in urine helps detect mast cell activation and related symptoms. |
High levels mean active mast cell release or allergic reaction.
Low levels mean no current mast cell activation. |
Reference ranges may change over time. For the most current values, visit the Quest Diagnostics lab test directory.
MCAS Panel Suggested by Dr. Jill Carnahan FAQ
Is there MCAS Panel Suggested by Dr. Jill Carnahan testing near me?
You can find nearby locations for MCAS Panel Suggested by Dr. Jill Carnahan using the patient service center locator, which also lists mobile phlebotomy options. For people with unpredictable allergic symptoms or sensitivities, having a convenient site makes sample collection easier and less stressful.
What is the cost of the test?
The price for the MCAS Panel Suggested by Dr. Jill Carnahan includes all fees, including sample collection at patient service center locations. Ordering this panel is worth it if you have ongoing symptoms that have not responded to standard allergy or immune testing.
How often should I retest?
Retesting is usually recommended every 6 to 12 months, or as symptoms change, to track progress and adjust treatment. Regular monitoring helps catch changes in immune markers and mast cell activity that may need a new approach.
How accurate is the test?
This panel uses advanced immunoassay, ELISA, and mass spectrometry methods, with specificity and sensitivity rates above 95% for most markers. TrueHealthLabs.com works with CLIA-certified labs to maintain high-quality testing standards you can trust.
Important Notes
- This test cannot be collected in NY, NJ, MA, and RI. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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