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Metabolic Analysis Test | Europe


  • Home Test Kit
  • Processed by Genova Diagnostics
  • Turnaround Time: 5-8 Business Days on Average. Time may vary.
  • Not Available in: NY
  • HSA and FSA Approved

$399.00 USD $798.00

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Ordering the Metabolic Analysis Test | Europe

The Metabolic Analysis Test from Genova Diagnostics helps identify how your body processes nutrients, energy, and waste. This test measures organic acids in urine, which can show imbalances in metabolism, nutrient absorption, and gut health. Interestingly, certain organic acids can reveal early signs of vitamin and mineral deficiencies before symptoms appear. Ordering this test can help you and your healthcare provider find specific metabolic patterns that may be linked to symptoms like fatigue, brain fog, or digestive discomfort.

Ordering the Metabolic Analysis Test offers several specific benefits:

  • Detects nutrient deficiencies, such as B vitamins, before they become severe.
  • Identifies imbalances in gut bacteria that may cause bloating, gas, or skin issues.
  • Reveals problems with energy production that can lead to tiredness or trouble concentrating.
  • Highlights markers of oxidative stress, which can affect joint comfort and immune function.
  • Shows how well your body breaks down proteins, fats, and carbohydrates for energy.

Who Should Consider Metabolic Function Testing

People who feel tired even after a full night’s sleep, struggle with focus at work or school, or notice changes in digestion may benefit from this test. For example, someone who has tried different diets and supplements but still feels low energy and has trouble with memory might find answers through metabolic function testing.

Ordering this test may also be helpful in these situations:

  • Frequent headaches or migraines that do not improve with common treatments
  • Unexplained skin rashes or eczema that flare up after certain foods
  • Digestive changes like constipation or diarrhea that last for weeks
  • Sudden mood swings or feelings of anxiety without a clear cause
  • People who have a family history of metabolic or mitochondrial conditions, as early changes can sometimes be detected in organic acid profiles

This test can help pinpoint specific nutrient or metabolic imbalances that may be causing symptoms like fatigue, digestive changes, or skin problems. Delaying this test could mean missing early signs of nutrient shortages or gut imbalances, which may become harder to address if not found soon.

Preparing for Organic Acid and Metabolic Marker Testing

Fasting is not required for this test, but it is best to collect the urine sample first thing in the morning as directed in the kit instructions. Always follow any guidance or instructions provided by your doctor or healthcare professional to make sure your sample is collected correctly and your results are as useful as possible.

Labs Included When Ordering Your Metabolic Analysis Test

Test Name Reference Range What This Marker Means Low and High Levels of Metabolic Analysis Test
2-Hydroxyphenylacetic Acid (2-HPAA) 0–15 2-HPAA is a byproduct of protein breakdown and gut bacteria activity. It can reflect how well your body digests certain amino acids and the balance of gut microbes. High levels mean possible gut bacteria imbalance or protein digestion issues.

Low levels mean efficient protein breakdown or low intake of related amino acids.

3-Hydroxyisovaleric Acid 0–7 This marker is linked to the breakdown of the amino acid leucine. It can show if your body is using certain B vitamins properly. High levels mean possible biotin (vitamin B7) deficiency or metabolic stress.

Low levels mean normal leucine metabolism.

3-Hydroxyphenylacetic Acid 0–15 This acid is a product of tyrosine metabolism and gut bacteria. It can reflect both protein digestion and gut health. High levels mean increased gut bacteria activity or protein breakdown.

Low levels mean balanced tyrosine metabolism.

3-Hydroxyproprionic Acid (3HPA) 0–7 3HPA is a marker for certain gut bacteria and can also reflect how your body processes fats and carbohydrates. High levels mean possible gut bacteria imbalance or metabolic stress.

Low levels mean normal fat and carbohydrate metabolism.

3-Methyl-4-OH-phenylglycol (MHPG) 0–10 MHPG is a breakdown product of norepinephrine, a brain chemical. It can show how your body handles stress and mood regulation. High levels mean increased stress response or nervous system activity.

Low levels mean reduced norepinephrine turnover.

4-Hydroxyphenylacetic Acid 0–15 This marker comes from tyrosine breakdown and gut bacteria. It can reflect both protein digestion and gut microbial balance. High levels mean gut bacteria imbalance or increased protein breakdown.

Low levels mean balanced tyrosine metabolism.

5-OH-indoleacetic Acid (5-HIAA) 2–15 5-HIAA is the main breakdown product of serotonin, a brain chemical. It can show how your body processes serotonin, which affects mood and digestion. High levels mean increased serotonin breakdown, sometimes linked to certain tumors or gut issues.

Low levels mean low serotonin production or use.

α-Hydroxyisobutyric Acid 0–7 This acid is a byproduct of protein and fat breakdown. It can reflect how your body uses energy from food. High levels mean increased protein or fat breakdown.

Low levels mean normal energy metabolism.

α-Ketophenylacetic Acid 0–10 This marker is linked to the breakdown of phenylalanine, an amino acid. It can show how well your body processes certain proteins. High levels mean possible metabolic block in phenylalanine breakdown.

Low levels mean normal phenylalanine metabolism.

α-Keto-b-Methylvaleric Acid (AKBM) 0–7 AKBM is a byproduct of branched-chain amino acid metabolism. It can reflect how your body uses certain proteins for energy. High levels mean possible metabolic block in branched-chain amino acid breakdown.

Low levels mean normal protein metabolism.

α-Ketoadipic Acid (AKAA) 0–7 AKAA is a marker for lysine and tryptophan metabolism. It can show how your body processes these amino acids. High levels mean possible metabolic block in lysine or tryptophan breakdown.

Low levels mean normal amino acid metabolism.

α-Ketoglutaric Acid (AKA) 2–15 AKA is a key part of the energy cycle in cells. It can show how well your body produces energy from food. High levels mean possible energy production issues or increased protein breakdown.

Low levels mean normal energy metabolism.

α-Ketoisocaproic Acid (AKIC) 0–7 AKIC is a byproduct of leucine metabolism. It can reflect how your body uses this amino acid for energy. High levels mean possible metabolic block in leucine breakdown.

Low levels mean normal leucine metabolism.

α-Ketoisovaleric Acid (AKIV) 0–7 AKIV is a byproduct of valine metabolism. It can show how your body processes this amino acid. High levels mean possible metabolic block in valine breakdown.

Low levels mean normal valine metabolism.

Adipic Acid 0–7 Adipic acid is a marker for fat breakdown. It can show how your body uses fats for energy. High levels mean increased fat breakdown or possible metabolic stress.

Low levels mean normal fat metabolism.

Arabinose 0–47 Arabinose is a sugar that can reflect yeast or fungal overgrowth in the gut. It is often used to check for candida. High levels mean possible yeast or fungal overgrowth.

Low levels mean no signs of yeast overgrowth.

b-OH-b-Methylglutaric Acid (HMG) 0–7 HMG is a marker for cholesterol and energy production. It can show how your body makes and uses cholesterol. High levels mean possible metabolic block in cholesterol production.

Low levels mean normal cholesterol metabolism.

b-OH-Butyric Acid (BHBA) 0–7 BHBA is a ketone body, showing how your body uses fat for energy, especially during fasting or low-carb diets. High levels mean increased fat burning or possible diabetes.

Low levels mean low fat breakdown.

Benzoic Acid 0–7 Benzoic acid is a byproduct of gut bacteria and food preservatives. It can reflect gut health and exposure to certain foods. High levels mean increased gut bacteria activity or high intake of preservatives.

Low levels mean normal gut bacteria activity.

Cis-Aconitic Acid 0–7 Cis-aconitic acid is part of the energy cycle in cells. It can show how well your body produces energy from food. High levels mean possible energy production issues.

Low levels mean normal energy metabolism.

Citramalic Acid 0–7 Citramalic acid is a byproduct of certain gut bacteria. It can reflect gut microbial balance and digestion. High levels mean possible gut bacteria imbalance.

Low levels mean balanced gut bacteria.

Citric Acid 180–820 Citric acid is a key part of the energy cycle. It can show how well your body turns food into energy. High levels mean increased energy production or possible metabolic stress.

Low levels mean low energy production.

Creatinine 500–2000 Creatinine is a waste product from muscles. It helps check kidney function and ensures urine sample quality. High levels mean possible kidney stress or high muscle mass.

Low levels mean low muscle mass or diluted urine.

Dihydroxyphenylpropionic Acid (DHPPA) 0–7 DHPPA is a byproduct of gut bacteria. It can reflect the balance of beneficial bacteria in the gut. High levels mean increased beneficial gut bacteria.

Low levels mean low beneficial gut bacteria.

Formiminoglutamic Acid (FIGlu) 0–2 FIGlu is a marker for folate (vitamin B9) status. It can show if your body is getting enough folate. High levels mean possible folate deficiency.

Low levels mean normal folate status.

Glutaric Acid 0–7 Glutaric acid is a byproduct of amino acid breakdown. It can reflect how your body processes certain proteins. High levels mean possible metabolic block in amino acid breakdown.

Low levels mean normal protein metabolism.

Hippuric Acid 0–250 Hippuric acid is a byproduct of gut bacteria and detoxification. It can reflect gut health and exposure to certain foods or chemicals. High levels mean increased gut bacteria activity or detoxification.

Low levels mean low gut bacteria activity.

Homogentisic Acid 0–7 Homogentisic acid is a byproduct of tyrosine and phenylalanine metabolism. It can show how your body processes these amino acids. High levels mean possible metabolic block in amino acid breakdown.

Low levels mean normal amino acid metabolism.

Homovanillic Acid (HVA) 2–15 HVA is a breakdown product of dopamine, a brain chemical. It can show how your body processes dopamine, which affects mood and movement. High levels mean increased dopamine breakdown.

Low levels mean low dopamine production or use.

Indoleacetic Acid (IAA) 0–15 IAA is a byproduct of tryptophan metabolism and gut bacteria. It can reflect protein digestion and gut health. High levels mean increased gut bacteria activity or protein breakdown.

Low levels mean balanced tryptophan metabolism.

Isocitric Acid 0–7 Isocitric acid is part of the energy cycle. It can show how well your body turns food into energy. High levels mean possible energy production issues.

Low levels mean normal energy metabolism.

Isovalerylglycine 0–7 Isovalerylglycine is a byproduct of leucine metabolism. It can reflect how your body uses this amino acid for energy. High levels mean possible metabolic block in leucine breakdown.

Low levels mean normal leucine metabolism.

Kynurenic Acid 0–7 Kynurenic acid is a byproduct of tryptophan metabolism. It can show how your body processes this amino acid, which affects mood and brain function. High levels mean increased tryptophan breakdown.

Low levels mean low tryptophan metabolism.

Kynurenic/Quinolinic Acid Ratio 0.1–1.0 This ratio helps show the balance of tryptophan breakdown products, which can affect brain and immune function. High levels mean more kynurenic acid, which may affect brain function.

Low levels mean more quinolinic acid, which may increase inflammation.

Lactic Acid 0–20 Lactic acid is a byproduct of energy production, especially during exercise or low oxygen. It can show how your body handles energy needs. High levels mean increased energy demand or low oxygen.

Low levels mean normal energy metabolism.

Malic Acid 0–7 Malic acid is part of the energy cycle. It can show how well your body turns food into energy. High levels mean possible energy production issues.

Low levels mean normal energy metabolism.

Methylmalonic Acid (MMA) 0–2 MMA is a marker for vitamin B12 status. It can show if your body is getting enough B12 for energy and nerve function. High levels mean possible vitamin B12 deficiency.

Low levels mean normal B12 status.

Orotic Acid 0–2 Orotic acid is a byproduct of DNA and RNA production. It can show how your body makes new cells and processes ammonia. High levels mean possible urea cycle disorder or cell turnover.

Low levels mean normal cell production.

Oxidative Stress Markers: lipid peroxides 0–7 Lipid peroxides are markers of cell damage from free radicals. They can show if your body is under oxidative stress. High levels mean increased cell damage or inflammation.

Low levels mean low oxidative stress.

Phenylacetic Acid (PAA) 0–15 PAA is a byproduct of phenylalanine metabolism. It can show how your body processes this amino acid. High levels mean possible metabolic block in phenylalanine breakdown.

Low levels mean normal phenylalanine metabolism.

Pyroglutamic Acid 0–7 Pyroglutamic acid is a marker for glutathione status, an important antioxidant. It can show if your body is making enough glutathione. High levels mean possible glutathione deficiency or oxidative stress.

Low levels mean normal glutathione status.

Pyruvic Acid 0–7 Pyruvic acid is a key part of energy production. It can show how well your body turns glucose into energy. High levels mean possible energy production issues.

Low levels mean normal glucose metabolism.

Quinolinic Acid 0–7 Quinolinic acid is a byproduct of tryptophan metabolism. It can affect brain and immune function. High levels mean increased inflammation or brain stress.

Low levels mean low tryptophan metabolism.

Suberic Acid 0–7 Suberic acid is a byproduct of fat breakdown. It can show how your body uses fats for energy. High levels mean increased fat breakdown or metabolic stress.

Low levels mean normal fat metabolism.

Succinic Acid 0–7 Succinic acid is part of the energy cycle. It can show how well your body turns food into energy. High levels mean possible energy production issues.

Low levels mean normal energy metabolism.

Tartaric Acid 0–7 Tartaric acid is a byproduct of certain gut bacteria and yeast. It can reflect gut microbial balance. High levels mean possible yeast or bacterial overgrowth.

Low levels mean balanced gut microbes.

Vanilmandelic Acid (VMA) 2–15 VMA is a breakdown product of adrenaline and noradrenaline. It can show how your body handles stress and nervous system activity. High levels mean increased stress hormone breakdown.

Low levels mean low stress hormone production.

Xanthurenic Acid 0–7 Xanthurenic acid is a byproduct of tryptophan metabolism and vitamin B6 status. It can show if your body is getting enough B6. High levels mean possible vitamin B6 deficiency.

Low levels mean normal B6 status.

Oxidative Stress Markers: lipid peroxides 0–7 Lipid peroxides are markers of cell damage from free radicals. They can show if your body is under oxidative stress. High levels mean increased cell damage or inflammation.

Low levels mean low oxidative stress.

Reference ranges may change slightly as labs update their methods or as new research becomes available. Always check your report for the most current reference values.


Metabolic Analysis Test FAQ

Is there Metabolic Analysis Test testing near me?

This is a urine test kit that you can collect at home and send to the lab, with local draw locations available if needed. For people dealing with ongoing fatigue or digestive issues, having a convenient collection option helps avoid delays and makes it easier to get answers quickly.

How do I interpret the test results?

While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.

What is the cost of the test?

The price shown includes standard shipping to you and return shipping to the lab, but local draw fees may apply. Ordering this test can help you find the root cause of symptoms like fatigue or brain fog, so you can start targeted support sooner.

How often should I retest?

Retesting is usually recommended every 6 to 12 months, especially if you are making changes to your diet or supplements. Regular testing helps track improvements in nutrient absorption and metabolic balance over time.

How accurate is the test?

This test uses gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for precise measurement of organic acids, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.


Medical Review Board

Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.

Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.


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