Ordering the Lyme ImmunoBlot IgG, IgM | Igenex
The Lyme ImmunoBlot IgG, IgM from IgeneX is a specialized blood test that helps detect antibodies to Borrelia burgdorferi, the bacteria linked to Lyme disease. This test is often used when symptoms like joint pain, memory problems, or neurological changes appear after a tick bite or unexplained illness. Interestingly, the ImmunoBlot can identify multiple strains of Borrelia, which may not be picked up by standard Lyme tests, making it useful for people with complex or long-standing symptoms.
Ordering this test can help you and your healthcare provider:
- Detect both early and late-stage Lyme disease by measuring IgG and IgM antibodies.
- Identify infections that may not show up on standard Lyme tests.
- Support decisions about further testing for co-infections like Babesia or Bartonella.
- Track changes in antibody levels over time to monitor response to treatment.
- Provide documentation for insurance or workplace accommodations if needed.
Who Should Consider Advanced Tick-Borne Disease Testing
People who have spent time in wooded or grassy areas and later develop symptoms such as fatigue, joint pain, or brain fog may benefit from this test. For example, someone who enjoys hiking and later notices unexplained muscle aches and memory issues might want to order this test to check for Lyme disease and related infections.
Ordering may also be helpful in these situations:
- After a tick bite followed by a rash or flu-like symptoms.
- When experiencing ongoing neurological symptoms like tingling or numbness.
- If you have chronic joint pain that has not improved with standard treatments.
- For those with a history of travel to areas where Lyme disease is common.
- In cases where unexplained heart palpitations develop after outdoor exposure, as Lyme can affect the heart.
This test can help confirm or rule out Lyme disease, guide treatment, and support decisions about further testing for co-infections. Delaying this test could mean missing the best window for early detection, which may make treatment more complex later on. To move forward, consider ordering if you recognize any of these scenarios.
How to Prepare for Tick-Borne Antibody Testing
Fasting is not required for this test, so you can eat and drink as usual before your blood draw. Always follow any specific instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Lyme ImmunoBlot IgG, IgM | Igenex
| Test Name | Reference Range | Significance | Low and High Levels of Lyme ImmunoBlot IgG, IgM | Igenex |
|---|---|---|---|
| Lyme ImmunoBlot IgG | Positive: ≥5 B. burgdorferi proteins | This marker checks for IgG antibodies, which usually appear weeks after infection and can indicate a current or past Lyme disease infection. It helps confirm exposure to Borrelia burgdorferi and supports diagnosis in people with ongoing symptoms. |
High levels mean your immune system has responded to Borrelia burgdorferi, suggesting a current or previous infection.
Low levels mean there is little or no evidence of past or ongoing infection with Borrelia burgdorferi. |
| Lyme ImmunoBlot IgM | Positive: ≥2 B. burgdorferi proteins (early infection) | This marker detects IgM antibodies, which are produced early in the infection. It is useful for identifying recent or active Lyme disease, especially in the first few weeks after symptoms begin. |
High levels mean your body is likely fighting a recent or ongoing infection with Borrelia burgdorferi.
Low levels mean there is little or no evidence of a recent infection with Borrelia burgdorferi. |
Reference ranges may be updated from time to time as new research and guidelines become available. Always review your results with your healthcare provider for the most current interpretation.
Lyme ImmunoBlot FAQ
Is there Lyme ImmunoBlot testing near me?
This is a test kit that you can collect locally, and you can check the draw location link at the top of the page. Because symptoms like joint pain or memory problems can make travel difficult, having a nearby collection site makes it easier to get tested quickly and comfortably.
How do I interpret the test results?
While your treating physician should always review your results, we also offer a one-on-one test results review with our clinical team to help you understand your report and next steps.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, but draw fees may apply. Ordering this test can help you identify Lyme disease sooner, which may lead to faster relief from symptoms like fatigue or joint pain.
How often should I retest?
Retesting is usually recommended if symptoms return or change, or if you are monitoring your response to treatment, which is often every 3-6 months. Regular testing can help track changes in antibody levels and guide your treatment plan more effectively.
How accurate is the test?
This test uses the ImmunoBlot method, which separates and detects antibodies to specific Borrelia proteins for high sensitivity and specificity. The test has a sensitivity of 98% and a specificity of 98%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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