Ordering the LGI1 (Limbic Encephalitis) Antibody Test
The LGI1 (Limbic Encephalitis) Antibody Test helps detect antibodies linked to autoimmune brain inflammation, which can cause memory loss, confusion, and changes in mood or behavior. This test is often used when symptoms suggest possible autoimmune encephalitis, especially if other causes have been ruled out. Interestingly, research shows that early detection of LGI1 antibodies can help prevent long-term neurological problems by allowing for earlier treatment.
Ordering this test can help you and your doctor find out if your symptoms are related to an autoimmune reaction in the brain. Some specific benefits of ordering include:
- Identifies the presence of LGI1 antibodies that may be causing neurological symptoms
- Supports diagnosis of autoimmune limbic encephalitis for targeted treatment
- Helps distinguish between autoimmune and other causes of neurological changes
- Guides treatment decisions to reduce the risk of lasting brain injury
- Provides a clear answer when symptoms are unexplained or do not fit typical patterns
Who Should Consider This Autoimmune Brain Antibody Test
People who have been experiencing unexplained memory loss, confusion, or sudden changes in mood or personality may benefit from this test. For example, someone who has recently started forgetting familiar names, feels unusually irritable, and has trouble finding words might want to check if an autoimmune process is affecting their brain.
Ordering may also be helpful in these situations:
- Sudden onset of seizures without a clear cause
- Unexplained coordination problems or muscle weakness
- Persistent headaches with new behavioral changes
- Visual disturbances paired with mental fog or confusion
- Episodes of dizziness and nausea that do not improve with standard treatments
Testing for these antibodies can help pinpoint the reason for neurological symptoms, allowing for more focused treatment and monitoring. Delaying this test could mean missing the chance to start therapy early, which may lead to more severe or lasting brain changes.
Preparing for Your Brain Autoantibody Blood Test
Fasting is not required before this test, so you can eat and drink as usual. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your LGI1 (Limbic Encephalitis) Antibody Test
| Test Name | Reference Range | Significance | Low and High Levels of LGI1 (Limbic Encephalitis) Antibody |
|---|---|---|---|
| Anti-LGI1 Antibody | Negative: <1:10 Positive: ≥1:10 |
This test checks for antibodies against LGI1, a protein linked to autoimmune brain inflammation. Detecting these antibodies can help explain symptoms like memory loss, confusion, or seizures. |
High levels mean the immune system may be attacking the brain, which can cause neurological symptoms.
Low levels mean it is unlikely that LGI1 antibodies are causing symptoms. |
Reference ranges may change slightly as labs update their methods or as new research becomes available. Always check your report for the most current information.
LGI1 (Limbic Encephalitis) Antibody Test FAQ
Is there LGI1 (Limbic Encephalitis) Antibody Test testing near me?
This test is available as a kit that can be collected at a local draw site—see the draw location link for options. Since symptoms like confusion or memory loss can make travel difficult, having a nearby collection site makes the process easier and more accessible.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation.
What is the cost of the test?
The price listed for this test includes standard shipping to you and return shipping to the lab, though draw fees may apply at the collection site. Ordering this test can help you get answers about symptoms like memory loss or confusion, which may speed up finding the right treatment.
How often should I retest?
Retesting is usually recommended if symptoms return or change, or after starting treatment to monitor progress. Checking again can help track how well therapy is working and if antibody levels are decreasing.
How accurate is the test?
This test uses cell-based immunofluorescence assay technology, which is highly specific for LGI1 antibodies. Sensitivity is about 95% and specificity is 98%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test cannot be collected in NY, NJ, MA, and RI. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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