Ordering the Immunofixation (IFE), Serum Test
The Immunofixation (IFE), Serum test helps identify abnormal proteins in the blood, which can be linked to certain conditions affecting the immune system and bone marrow. This test is often used to help diagnose or monitor disorders like multiple myeloma, Waldenström macroglobulinemia, and other plasma cell diseases. Interestingly, the IFE test can also help distinguish between different types of abnormal proteins, which is important for choosing the right treatment plan.
Ordering this test can provide clear answers about the presence and type of abnormal proteins in your blood. When you order the Immunofixation (IFE), Serum test, you can expect:
- Detection of abnormal immunoglobulins (IgG, IgA, IgM) that may indicate plasma cell disorders
- Identification of monoclonal proteins, which can help with early diagnosis of certain blood cancers
- Monitoring of known conditions to track changes in protein levels over time
- Guidance for further testing or treatment decisions based on specific protein patterns
- Support in ruling out or confirming suspected immune system disorders
Who Might Benefit from Immunoglobulin Pattern Testing
People who have unexplained fatigue, frequent infections, or bone pain may benefit from this test. For example, someone who has been feeling tired for months and has noticed unusual bruising or recurring infections might find this test helpful in finding the cause.
Ordering this test may also be helpful in these situations:
- Someone with a family history of blood disorders who wants to check for early signs
- People with abnormal results from other blood protein tests, such as serum protein electrophoresis
- Those being monitored for changes after treatment for a plasma cell disorder
- People with unexplained high calcium levels, which can sometimes be linked to abnormal proteins
- Someone with chronic kidney problems, since certain protein abnormalities can affect kidney function
This test should be ordered to help detect, confirm, or monitor abnormal proteins that may be linked to specific blood or immune system conditions. Delaying this test could mean missing early changes in protein levels, which may affect how soon a diagnosis is made or how well a condition is managed.
Preparing for Immunofixation Analysis
No fasting is needed before the Immunofixation (IFE), Serum test, so you can eat and drink as usual before your blood draw. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected and processed correctly.
Labs Included When Ordering Your Immunofixation (IFE), Serum Test
| Test Name | Reference Range | What This Test Measures | Low and High Levels of Immunofixation (IFE), Serum |
|---|---|---|---|
| Immunofixation (IFE), Serum | No monoclonal protein detected | This test checks for abnormal immunoglobulins (IgG, IgA, IgM) in your blood. It helps identify monoclonal proteins, which can be linked to certain blood and immune system disorders. |
High levels mean there may be a monoclonal protein present, which can be a sign of a plasma cell disorder or blood cancer.
Low levels mean no abnormal monoclonal proteins were found, which is usually a normal result. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Immunofixation (IFE), Serum FAQ
Is there Immunofixation (IFE), Serum testing near me?
You can find nearby locations for Immunofixation (IFE), Serum using the patient service center locator, which also lists mobile phlebotomy options. For people who need regular monitoring of abnormal proteins, having a convenient testing site makes it easier to keep up with follow-up blood draws and avoid travel delays.
What is the cost of the test?
The price for the Immunofixation (IFE), Serum test includes all fees, such as sample collection at patient service center locations. Ordering this test is worth it if you need to check for abnormal proteins that could affect your immune system or bone marrow.
How often should I retest?
Retesting is usually recommended every 3 to 6 months for people being monitored for plasma cell disorders or after treatment, but your doctor may suggest a different schedule based on your results. Regular retesting helps track changes in abnormal protein levels, which can guide treatment or further testing.
How accurate is the test?
The Immunofixation (IFE), Serum test uses immunofixation electrophoresis, a method that separates and identifies specific proteins in the blood. This test has a specificity of 99% and a sensitivity of 97% for detecting monoclonal proteins. All tests at TrueHealthLabs.com are performed by CLIA-certified labs, meeting strict quality and precision standards.
Important Notes
None.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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