Ordering the Histamine Test
Ordering the Histamine Test helps detect abnormal histamine levels in your blood, which can be linked to symptoms like unexplained rashes, digestive issues, or headaches. Interestingly, histamine is not only involved in allergic reactions but also plays a role in regulating stomach acid and brain function.
When ordering this test, you can expect the following specific benefits:
- Pinpoints if high histamine is causing skin reactions or flushing.
- Helps identify if digestive discomfort is related to histamine intolerance.
- Assists in evaluating unexplained headaches or migraines.
- Supports diagnosis of rare conditions like mast cell activation syndrome.
- Guides dietary changes by confirming histamine sensitivity.
Who Should Consider Histamine Level Screening
People who experience frequent hives, stomach pain after eating certain foods, or ongoing headaches may benefit from this test. For example, someone who notices that their symptoms worsen after eating aged cheese or smoked meats might find answers by checking their histamine levels.
Ordering this test may also be helpful in these situations:
- Recurring skin redness or swelling without a clear cause
- Digestive upset after eating foods high in histamine
- Chronic nasal congestion not linked to seasonal allergies
- Unexplained fatigue that seems to follow certain meals
- People with a family history of mast cell disorders, as this can sometimes be overlooked
Testing for histamine levels can reveal if symptoms are linked to histamine intolerance or another underlying issue, allowing for targeted treatment or dietary changes. Delaying this test may result in ongoing symptoms and make it harder to identify which foods or triggers are causing problems.
Preparing for Plasma Histamine Measurement
Fasting is not required for this test, but it is recommended to avoid foods high in histamine for 24 hours before your blood draw. Always follow any instructions your doctor or healthcare provider gives you to make sure your results are as helpful as possible.
Labs Included When Ordering Your Histamine Test
| Test Name | Reference Range | What This Measures | Low and High Levels of Histamine Test |
|---|---|---|---|
| Histamine (Plasma) | 0.1 – 1.0 | This test measures the amount of histamine in your blood, which can show if your body is reacting to foods, allergies, or other triggers. It helps identify if symptoms like rashes, headaches, or stomach pain are linked to histamine levels. |
High levels mean your body may be reacting to allergies, certain foods, or mast cell disorders.
Low levels mean your symptoms are less likely to be caused by histamine intolerance. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Histamine Test FAQ
Is there histamine testing near me?
You can find nearby locations for histamine testing using the patient service center locator, which also lists mobile phlebotomy options for those who have trouble traveling or need quick sample collection due to unpredictable symptoms.
What is the cost of the test?
The price you see for the test includes all fees, including sample collection at patient service center locations. Ordering this test is worth it if you have ongoing symptoms that may be linked to histamine, as it can help you find answers and guide your next steps.
How often should I retest?
Retesting is usually recommended every 3 to 6 months if you are monitoring changes in symptoms or adjusting your diet. Regular testing helps track how your histamine levels respond to new foods or treatments.
How accurate is the test?
This test uses high-performance liquid chromatography (HPLC) to measure histamine in plasma, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com works with CLIA-certified labs to maintain high-quality testing standards you can trust.
Important Notes
- Avoid taking allergy-causing drugs, antihistamines, oral corticosteroids, and substances which block H2 receptors 24 hours prior to collection.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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