Ordering the Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition
Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition helps detect past exposure to both types of herpes simplex virus and can clarify results if HSV-2 IgG levels are elevated. This test is often used to confirm if someone has been exposed to either HSV-1 or HSV-2, even if they do not have symptoms. Interestingly, the reflex to HSV-2 inhibition is a follow-up step that helps reduce the chance of a false positive result for HSV-2, which can sometimes occur with standard antibody tests.
Ordering this test provides several specific benefits:
- Distinguishes between HSV-1 and HSV-2 exposure for more targeted information.
- Offers a reflex inhibition step to confirm HSV-2 results if initial values are high.
- Supports early detection, even in the absence of symptoms.
- Helps guide decisions about personal relationships and family planning.
- Provides documentation for medical records or partner notification if needed.
Who Might Benefit from Herpes Antibody Screening
People who have had a new partner and want to know their herpes status may find this test helpful, especially if they are planning for the future or have concerns about possible exposure. For example, someone who recently started a new relationship and wants to be open about their health may choose to order this test for peace of mind and transparency.
Ordering this test may also be useful in these situations:
- Someone with mild or recurring mouth or genital sores who wants to know the cause.
- A person whose partner has tested positive for herpes and wants to check their own status.
- Someone who is pregnant or planning pregnancy and needs to know their risk of passing herpes to a baby.
- People with a history of other sexually transmitted infections who want a full screening.
- Someone with unexplained nerve pain or tingling, as herpes can sometimes cause these symptoms even without visible sores.
This test is ordered to confirm if herpes simplex virus antibodies are present, which can help with planning, treatment, and reducing the risk of unknowingly passing the virus to others. Delaying this test could mean missing the chance to clarify your status, which may lead to confusion or unnecessary worry if symptoms appear later.
Preparing for Herpes Virus Blood Testing
Fasting is not required for the Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition test, so you can eat and drink as usual before your blood draw. Always follow any directions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition
| Test Name | Reference Range | What This Biomarker Means | Low and High Levels of This Test |
|---|---|---|---|
| Herpes Simplex Virus Type 1, IgG | Negative: <0.91 Equivocal: 0.91-1.09 Positive: >1.09 |
This marker checks for antibodies to HSV-1, which is often linked to cold sores but can also cause genital herpes. A positive result means your body has made antibodies to HSV-1, showing past or current infection. |
High levels mean you have been exposed to HSV-1 and your immune system has responded.
Low levels mean you have not been exposed to HSV-1 or it is too early for antibodies to show. |
| Herpes Simplex Virus Type 2, IgG | Negative: <0.91 Equivocal: 0.91-1.09 Positive: >1.09 |
This test looks for antibodies to HSV-2, which is most often linked to genital herpes. A positive result means you have been exposed to HSV-2 and your body has made antibodies in response. |
High levels mean you have been exposed to HSV-2 and your immune system has responded.
Low levels mean you have not been exposed to HSV-2 or it is too early for antibodies to show. |
| Reflex to HSV-2 Inhibition if HSV2 IgG is >1.09 | Negative: <1.10 Positive: >1.10 |
If your HSV-2 IgG result is positive, this follow-up test helps confirm if the result is true or a false positive. It increases confidence in the result by using a different method to check for HSV-2 antibodies. |
High levels mean the positive HSV-2 result is confirmed and you have HSV-2 antibodies.
Low levels mean the initial positive result may have been a false positive and you likely do not have HSV-2 antibodies. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Herpes Simplex Virus 1 and 2 FAQ
Is there Herpes Simplex Virus 1 and 2 testing near me?
You can find nearby locations for Herpes Simplex Virus 1 and 2 testing using the patient service center locator, which also lists mobile phlebotomy options for added convenience. This is especially helpful if you want quick, private sample collection without long travel or waiting times.
What is the cost of the test?
The price you see for this test includes all fees, including sample collection at patient service center locations. Ordering this test is worth it if you want clear answers about herpes exposure, especially when symptoms are mild or unclear.
How often should I retest?
Retesting is usually recommended if you have a new exposure risk or if your first test was done less than 12 weeks after possible contact, as it can take time for antibodies to appear. Reordering helps confirm your status and ensures you have the most up-to-date information for your situation.
How accurate is the test?
This test uses an enzyme-linked immunosorbent assay (ELISA) for initial screening and a confirmatory inhibition assay for HSV-2, with specificity of 98% and sensitivity of 97%. All tests at TrueHealthLabs.com are performed by CLIA-certified labs, meeting strict quality and precision standards.
Important Notes
- This test cannot be collected in NY, NJ, MA, and RI. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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