Ordering the Epstein-Barr Profile (Mono Test)
The Epstein-Barr Profile (Mono Test) helps detect antibodies linked to Epstein-Barr virus, which is the main cause of mononucleosis. This test checks for different types of antibodies, including VCA IgM, VCA IgG, and EBNA IgG, to show if there is a current or past infection. Interestingly, some people can carry the Epstein-Barr virus without showing any symptoms, but the test can still detect these silent infections.
Ordering this test can help you:
- Find out if your symptoms are caused by Epstein-Barr virus or another illness.
- See if you have a recent, past, or reactivated infection.
- Get clear results to help your doctor decide on the next steps for care.
- Track changes in your antibody levels over time.
- Rule out other causes of tiredness, sore throat, or swollen glands.
Who Should Consider Epstein-Barr Virus Antibody Testing
People who have been feeling tired for weeks, have a sore throat that won’t go away, or notice swollen glands may want to check for Epstein-Barr virus. For example, a student who keeps missing school because of ongoing fatigue and sore throat might benefit from this test to find out if Epstein-Barr virus is the cause.
Ordering this test may also be helpful in these situations:
- Someone with a long-lasting fever and no clear reason.
- A person who has had close contact with someone diagnosed with mononucleosis.
- Someone with unexplained swollen lymph nodes.
- A person with a weakened immune system who needs to check for viral infections.
- Someone who has had a recent blood transfusion and is now feeling unwell, since Epstein-Barr virus can sometimes be spread this way.
This test is useful for finding out if Epstein-Barr virus is causing your symptoms, which can help guide treatment and avoid unnecessary antibiotics. Delaying this test could mean waiting longer for answers and possibly missing the best time to track the infection.
Take the next step to get clear answers by ordering your test today.
Preparing for Epstein-Barr Virus Antibody Screening
Fasting is not needed before this blood test, so you can eat and drink as usual. Always follow any directions your doctor or healthcare provider gives you to make sure your sample is collected the right way.
Labs Included When Ordering Your Epstein-Barr Profile (Mono Test)
| Test Name | Reference Range | What This Biomarker Means | Low and High Levels of Epstein-Barr Profile (Mono Test) |
|---|---|---|---|
| Epstein-Barr Virus VCA (Viral Capsid Antigen) Antibody (IgM) | Negative | This antibody shows up early in infection and usually disappears within a few months. It helps identify a recent or current Epstein-Barr virus infection. |
High levels mean you likely have a new or active Epstein-Barr virus infection.
Low levels mean you probably do not have a recent infection or you are in the recovery stage. |
| Epstein-Barr Virus VCA (Viral Capsid Antigen) Antibody (IgG) | Negative | This antibody appears during the middle stage of infection and stays in the body for life. It shows if you have ever been exposed to Epstein-Barr virus. |
High levels mean you have had Epstein-Barr virus in the past or have a current infection.
Low levels mean you have likely never been exposed to Epstein-Barr virus. |
| Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG) | Negative | This antibody develops several months after infection and remains for life. It helps confirm a past Epstein-Barr virus infection and rules out a new infection. |
High levels mean you had Epstein-Barr virus in the past and are not in the early stage of infection.
Low levels mean you have not had Epstein-Barr virus or are in the early phase of infection. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Epstein-Barr Profile (Mono Test) FAQ
Is there Epstein-Barr Profile testing near me?
You can find a nearby location for Epstein-Barr Profile testing using the patient service center locator, which also lists mobile phlebotomy options. Since symptoms like ongoing fatigue and sore throat can make travel difficult, having a convenient site makes sample collection much easier.
What is the cost of the test?
The price you see for the Epstein-Barr Profile (Mono Test) covers everything, including the blood draw at a patient service center. Ordering this test is worth it if you want to pinpoint the cause of long-lasting tiredness or sore throat.
How often should I retest?
Retesting is usually only needed if your symptoms change or if your doctor wants to track your recovery, often within a few weeks to months. Repeating the test can help confirm if the infection is new, ongoing, or resolved.
How accurate is the test?
This test uses enzyme immunoassay (EIA) to detect Epstein-Barr virus antibodies, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com works with CLIA-certified labs to maintain high-quality testing standards you can trust.
Important Notes
- This test cannot be collected in NY, NJ, MA, and RI. Contact us with questions.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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