Ordering the Comprehensive Male Profile 2 | ZRT Labs
The Comprehensive Male Profile 2 from ZRT Labs measures a wide range of hormones and markers that can affect energy, mood, muscle mass, and metabolism. This test uses both saliva and blood spot samples to check levels of cortisol, thyroid hormones, testosterone, estrogen, and more, giving a detailed look at hormone balance and related health factors. Interestingly, this test includes four separate cortisol measurements throughout the day, which can help spot patterns in stress hormone changes that a single test might miss.
Ordering this test can help you:
- Track testosterone, estrogen, and DHEAS to see if hormone levels are linked to symptoms like low energy or changes in muscle mass.
- Check thyroid markers, including TSH, Free T3, Free T4, and thyroid antibodies, to spot possible thyroid issues early.
- Monitor prostate-specific antigen (PSA) for prostate health.
- Measure cortisol at four times during the day to see if stress hormone patterns are affecting sleep, mood, or weight.
- Get a full picture of hormone binding proteins, which can affect how much hormone is available for your body to use.
Who Should Consider Hormone and Thyroid Panel Testing
People who notice changes in energy, mood, or muscle mass, or who have unexplained weight gain or trouble sleeping, may benefit from this test. For example, someone who has been feeling more tired than usual, has noticed hair thinning, and is struggling to build muscle despite regular exercise could use this test to check if hormone or thyroid changes are playing a role.
Ordering this test may also be helpful in these situations:
- Experiencing mood swings, irritability, or trouble focusing that seem to come and go.
- Having a family history of thyroid or hormone-related conditions.
- Noticing a drop in libido or changes in sexual function.
- Seeing changes in cholesterol or blood sugar levels without a clear reason.
- Having a history of autoimmune conditions, since thyroid antibodies can sometimes be high even before symptoms appear.
Checking these markers can help spot hormone or thyroid changes that may be linked to symptoms like fatigue, memory problems, or changes in body composition. Delaying this test could mean missing early signs of hormone or thyroid shifts, which may make it harder to address symptoms quickly.
How to Prepare for the Hormone and Metabolism Home Test
Fasting is not required for this test, so you can eat and drink as usual before collecting your samples. Always follow any instructions your doctor or healthcare provider gives you to make sure your samples are collected correctly and your results are as useful as possible.
Labs Included When Ordering Your Comprehensive Male Profile 2
| Test Name | Reference Range | What This Test Shows | Low and High Levels of This Marker |
|---|---|---|---|
| Saliva Markers | |||
| Cortisol (Morning) | 3.7–9.5 ng/mL | This shows your stress hormone level right after waking up. It helps spot if your body is making too much or too little cortisol in the morning. | High levels mean your body may be under stress or you could have a cortisol-producing condition.
Low levels mean your adrenal glands may not be making enough cortisol, which can cause tiredness and low energy. |
| Cortisol (Noon) | 1.2–3.0 ng/mL | This checks how your cortisol drops by midday. It helps see if your stress hormone pattern is normal as the day goes on. | High levels mean ongoing stress or a possible hormone imbalance.
Low levels mean your body may not be keeping up with daily energy needs. |
| Cortisol (Evening) | 0.6–1.9 ng/mL | This measures cortisol in the evening, showing if your stress hormone is dropping as it should before bedtime. | High levels mean you may have trouble winding down or falling asleep.
Low levels mean your adrenal function may be low, which can cause fatigue. |
| Cortisol (Night) | 0.4–1.0 ng/mL | This checks your lowest cortisol level at night, which should be low for restful sleep and recovery. | High levels mean you may have sleep problems or nighttime stress.
Low levels mean your body may not be making enough cortisol overnight. |
| Blood Spot Markers | |||
| TSH | 0.5–3.0 μIU/mL | This is the main signal from your brain to your thyroid. It helps show if your thyroid is working too fast or too slow. | High levels mean your thyroid may be underactive.
Low levels mean your thyroid may be overactive. |
| Free T3 | 2.3–4.2 pg/mL | This is the active thyroid hormone that helps control energy, temperature, and metabolism. | High levels mean your thyroid is making too much hormone.
Low levels mean your body may not be getting enough thyroid hormone for energy and metabolism. |
| Free T4 | 0.8–1.8 ng/dL | This is another thyroid hormone that helps your body use energy and stay warm. | High levels mean your thyroid is overactive.
Low levels mean your thyroid is underactive. |
| TPO and Anti-TG Antibodies | <35 IU/mL | These are markers for thyroid autoimmunity, which can show if your immune system is affecting your thyroid. | High levels mean your immune system may be attacking your thyroid.
Low levels mean there is little or no sign of thyroid autoimmunity. |
| Estradiol | 10–40 pg/mL | This is a form of estrogen that can affect mood, memory, and body fat in men. | High levels mean you may have more body fat or changes in mood.
Low levels mean you may have low bone density or changes in sexual function. |
| Prostate-specific Antigen | 0–4 ng/mL | This marker helps check for changes in the prostate gland, which can be linked to age or other conditions. | High levels mean your prostate may be enlarged or inflamed.
Low levels mean your prostate is likely normal. |
| Testosterone | 350–950 ng/dL | This hormone supports muscle mass, energy, mood, and sexual function in men. | High levels mean you may have more muscle or changes in mood.
Low levels mean you may feel tired, lose muscle, or have low libido. |
| Sex Hormone Binding Globulin | 10–57 nmol/L | This protein controls how much testosterone and estrogen are available for your body to use. | High levels mean less free testosterone is available.
Low levels mean more free testosterone is available, which can affect symptoms. |
| DHEAS | 80–560 μg/dL | This hormone is made by the adrenal glands and helps with energy, mood, and hormone balance. | High levels mean your adrenal glands are more active.
Low levels mean you may feel tired or have low stress tolerance. |
Reference ranges may change slightly as labs update their standards, so always check your report for the most current values.
Comprehensive Male Profile 2 FAQ
Is there Comprehensive Male Profile 2 testing near me?
This is a home test kit, so you can collect your saliva and blood spot samples at home and send them in, making it easier if you have a busy schedule or trouble getting to a lab. If you need a local draw site for any part of the process, check the draw location link at the top of the page.
How do I interpret the test results?
While your treating physician should review your results, you can also use our one-on-one test results review service with our clinical team for a detailed explanation and next steps.
What is the cost of the test?
The price you see includes standard shipping to you and back to the lab, but some locations may charge a draw fee. Ordering this test can help you find out if hormone or thyroid changes are linked to symptoms like fatigue or weight gain, so you can address them sooner.
How often should I retest?
Retesting every 6 to 12 months is usually recommended, especially if you are starting or changing treatment, to track how your hormone and thyroid levels respond over time.
How accurate is the test?
This test uses saliva and blood spot collection, analyzed by mass spectrometry and immunoassay methods, with a specificity of 98% and sensitivity of 97%. TrueHealthLabs.com partners with CLIA-certified and CAP-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- The blood samples cannot be collected and mailed in the state of New York.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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