Ordering the Celiac Disease Test Panel
The Celiac Disease Test Panel helps detect immune responses linked to gluten sensitivity and celiac disease, which can cause digestive issues and nutrient absorption problems. Interestingly, some people with celiac disease may not have any stomach symptoms but can still develop complications like anemia or skin rashes.
Ordering this test can help you:
- Identify gluten-triggered immune reactions before symptoms become severe
- Pinpoint the cause of ongoing digestive discomfort or unexplained nutrient deficiencies
- Support your doctor in making a clear diagnosis, reducing the need for more invasive procedures
- Monitor your body’s response to a gluten-free diet if you have already started one
- Detect celiac disease even if you have mild or unusual symptoms
Who Should Consider Gluten Sensitivity and Autoimmune Gut Testing
People who have frequent stomach pain, bloating, or diarrhea after eating bread or pasta may benefit from this test. For example, someone who has been feeling tired and losing weight without knowing why might find answers by checking for gluten-related immune reactions.
Ordering this test may also be helpful if you:
- Have a family member diagnosed with celiac disease
- Experience ongoing iron deficiency or anemia that does not improve with supplements
- Notice a skin rash that does not respond to regular treatments
- Have unexplained joint pain or headaches that seem to worsen after eating certain foods
- Are planning to start a gluten-free diet and want a baseline for future comparison
This test can reveal if your immune system is reacting to gluten, which can help you and your doctor decide on the next steps for treatment or dietary changes. Delaying this test may lead to ongoing symptoms and missed chances to prevent long-term gut damage.
How to Prepare for Gluten-Related Antibody Blood Testing
Fasting is not required for this test, so you can eat and drink as usual before your blood draw. Always follow any instructions or special guidance your doctor or healthcare provider gives you to make sure your results are as helpful as possible.
Labs Included When Ordering Your Celiac Disease Test Panel
| Test Name | Reference Range | What This Test Measures | Low and High Levels of This Test |
|---|---|---|---|
| Endomysial Antibody IgA | Negative | This test looks for antibodies that attack the lining of the small intestine when gluten is eaten. It is highly specific for celiac disease and helps confirm the diagnosis. |
High levels mean your immune system is likely reacting to gluten, which is common in celiac disease.
Low levels mean there is little or no immune response to gluten, making celiac disease less likely. |
| Immunoglobulin A (Total IgA) | 70–400 | This test checks the total amount of IgA antibodies in your blood. It helps make sure your immune system can produce enough IgA for accurate celiac testing. |
High levels mean your body may be fighting an infection or inflammation.
Low levels mean you may not make enough IgA, which can affect the results of other celiac tests. |
| Tissue Transglutaminase (tTG) IgA | Negative | This test finds antibodies that target tissue transglutaminase, an enzyme in the gut. It is the main screening tool for celiac disease and is very sensitive. |
High levels mean your immune system is likely attacking your gut lining after eating gluten.
Low levels mean there is little or no immune response, so celiac disease is less likely. |
| Tissue Transglutaminase (tTG) IgG | Negative | This test checks for IgG antibodies against tissue transglutaminase. It is useful for people who have low total IgA, helping to detect celiac disease when other tests may not work. |
High levels mean your immune system is reacting to gluten, especially if you have low IgA.
Low levels mean there is little or no immune response, making celiac disease less likely. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Celiac Disease Test Panel FAQ
Is there Celiac Disease Test Panel testing near me?
You can find nearby locations for Celiac Disease Test Panel blood draws using the patient service center locator, which also lists mobile phlebotomy options. For those with ongoing digestive symptoms, having a convenient site makes it easier to get tested without added travel or stress.
What is the cost of the test?
The price shown for the Celiac Disease Test Panel includes all fees, including sample collection at patient service center locations. Ordering this test can help you pinpoint the cause of ongoing digestive issues and avoid unnecessary delays in diagnosis.
How often should I retest?
Retesting is usually recommended every 6–12 months if you are monitoring your response to a gluten-free diet or if your symptoms change. Regular testing helps track your immune response and ensures your treatment plan is working as expected.
How accurate is the test?
The Celiac Disease Test Panel uses enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence methods, with a sensitivity of 95% and specificity of 98% for detecting celiac-related antibodies. TrueHealthLabs.com partners with CLIA-certified laboratories to uphold rigorous testing standards for dependable results.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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