Ordering the Autoimmune Screening Test
Ordering the Autoimmune Screening Test helps detect antibodies that may be linked to autoimmune conditions such as rheumatoid arthritis, lupus, celiac disease, and Hashimoto’s thyroiditis. This test checks for specific markers in your blood that can show if your immune system is mistakenly attacking your own tissues. Interestingly, some people with autoimmune conditions may not have obvious symptoms at first, making early detection through lab testing especially useful for tracking changes over time.
When ordering the Autoimmune Screening Test, you can expect several specific benefits:
- Identifies antibodies linked to four of the most common autoimmune conditions.
- Helps your doctor decide if more detailed testing is needed for a specific diagnosis.
- Monitors changes in antibody levels to track disease activity or response to treatment.
- Supports early detection, even before symptoms become noticeable.
- Provides a clear starting point for managing unexplained symptoms related to immune function.
Who Might Benefit from Autoimmune Antibody Screening
People who have ongoing joint pain, unexplained fatigue, or digestive issues that do not improve with basic care may benefit from this screening. For example, someone who has been feeling tired for months, with new aches and swelling in their hands, might find answers by checking for autoimmune markers.
Ordering this test may also be helpful in these situations:
- Family members of people diagnosed with autoimmune conditions.
- People with long-lasting skin rashes that do not respond to common treatments.
- Those experiencing sudden changes in thyroid function or unexplained weight changes.
- Anyone with digestive problems that persist despite dietary changes.
- People who have frequent mouth ulcers, which can sometimes be linked to autoimmune activity.
This screening is recommended for those who want to pinpoint the cause of ongoing symptoms that may be related to immune system activity. Delaying this test could mean missing early signs of autoimmune activity, which may make it harder to manage symptoms or prevent further tissue damage. To move forward, consider ordering the screening to get clear answers about your immune system.
Preparing for Your Immune System Antibody Panel
Fasting is not required before this blood test, so you can eat and drink as usual. Always follow any specific instructions your doctor or healthcare provider gives you to make sure your sample is collected correctly and your results are as helpful as possible.
Labs Included When Ordering Your Autoimmune Screening Test
| Test Name | Reference Range | What This Test Measures | Low and High Levels of the Test |
|---|---|---|---|
| Rheumatoid Arthritis Factor (RA Factor) | 0–13 IU/mL | RA Factor checks for antibodies that are often found in people with rheumatoid arthritis. It helps identify immune system activity that targets the joints. |
High levels mean there may be an increased chance of rheumatoid arthritis or another autoimmune joint condition.
Low levels mean it is less likely that rheumatoid arthritis is present, but it does not rule it out completely. |
| Antinuclear Antibodies (ANA) | Negative (titer <1:40) | ANA detects antibodies that attack the cell nucleus, which are often seen in lupus and other autoimmune diseases. This test helps spot immune system changes early. |
High levels mean there may be an autoimmune process such as lupus or mixed connective tissue disease.
Low levels mean autoimmune activity is less likely, but some people with autoimmune conditions may still have a negative result. |
| Tissue Transglutaminase (tTG) IgA + IgG Antibodies | Negative (<4 U/mL) | This test looks for antibodies against tissue transglutaminase, which are linked to celiac disease. It helps find out if gluten is causing immune reactions in the gut. |
High levels mean there may be celiac disease or gluten sensitivity causing immune system activity in the intestines.
Low levels mean celiac disease is less likely, but further testing may be needed if symptoms continue. |
| Thyroglobulin Antibodies + Thyroid Peroxidase Antibodies (TGA/TPO Antibodies) | TPO: <9 IU/mL Thyroglobulin: <1 IU/mL |
These antibodies are checked to see if the immune system is attacking the thyroid, which can lead to Hashimoto’s thyroiditis. The test helps spot thyroid-related autoimmune activity. |
High levels mean there may be autoimmune thyroid disease, such as Hashimoto’s or Graves’ disease.
Low levels mean thyroid autoimmunity is less likely, but thyroid function should still be monitored if symptoms are present. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Autoimmune Screening Test FAQ
Is there Autoimmune Screening testing near me?
You can find nearby locations for Autoimmune Screening using the patient service center locator, which also lists mobile phlebotomy options for added convenience. For those with ongoing symptoms like joint pain or fatigue, having a close and accessible testing site makes it easier to get your blood drawn without extra travel or delays.
What is the cost of the test?
The price you see for the Autoimmune Screening Test includes all fees, including sample collection at patient service center locations. Ordering this test is worth it if you have unexplained symptoms that could be linked to immune system activity, as it can help guide your next steps.
How often should I retest?
Retesting is usually recommended every 6 to 12 months, or as directed by your healthcare provider, especially if you have ongoing symptoms or a diagnosed autoimmune condition. Regular testing helps track changes in antibody levels, which can be important for adjusting treatment or monitoring disease activity.
How accurate is the test?
The Autoimmune Screening Test uses enzyme-linked immunosorbent assay (ELISA) and immunofluorescence methods, which are known for high sensitivity (up to 98%) and specificity (up to 95%) for detecting autoimmune antibodies. TrueHealthLabs.com partners with CLIA-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
None.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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