Ordering the Antimyelin Associated Glycoprotein, IgM (Mag Ab) Test
Antimyelin Associated Glycoprotein, IgM (Mag Ab) testing helps detect antibodies that may target the protective covering of nerves, which can be linked to certain nerve disorders. This test is often used to help clarify the cause of unexplained numbness, tingling, or weakness, especially when other tests have not provided clear answers. Interestingly, research shows that elevated Mag Ab levels can sometimes be found in people with chronic neuropathies even before symptoms become noticeable, offering an early clue for further investigation.
Ordering this test can provide specific information about nerve-related antibody activity. When you order, you may benefit from:
- Pinpointing the presence of IgM antibodies against myelin-associated glycoprotein
- Supporting the diagnosis of certain types of peripheral neuropathy
- Helping guide treatment decisions for nerve-related symptoms
- Monitoring changes in antibody levels over time
- Identifying possible autoimmune activity affecting the nervous system
Who Might Need Mag Antibody Blood Testing
People who have been experiencing unexplained tingling, numbness, or weakness in their hands and feet, especially if these symptoms have lasted for several months, may find this test helpful. For example, someone who has noticed a gradual loss of sensation in their fingers and toes, making it difficult to button a shirt or walk comfortably, might benefit from ordering this test to help find the cause.
Ordering may also be considered in these situations:
- Long-term nerve symptoms that have not improved with standard treatments
- Family history of autoimmune nerve conditions
- Unexplained changes in muscle strength or coordination
- Previous abnormal nerve conduction studies needing further clarification
- People with monoclonal gammopathy, a blood protein abnormality, as it can sometimes be linked to Mag Ab-related neuropathy
This test can help identify if the immune system is producing antibodies that may be affecting the nerves, which can lead to more targeted treatment options. Delaying this test could mean missing early signs of nerve damage, which may make it harder to manage symptoms or slow progression later on.
Preparing for Your Nerve Antibody Blood Panel
Fasting is not required before this test, so you can eat and drink as usual. Always follow any instructions your doctor or healthcare provider gives you to make sure your sample is collected properly and your results are as useful as possible.
Labs Included When Ordering Your Antimyelin Associated Glycoprotein, IgM (Mag Ab) Test
| Test Name | Reference Range | What This Biomarker Means | Low and High Levels of Antimyelin Associated Glycoprotein, IgM (Mag Ab) |
|---|---|---|---|
| Antimyelin Associated Glycoprotein | Negative | This marker checks for antibodies that target the myelin-associated glycoprotein, a protein that helps protect nerve fibers. High levels may suggest immune system activity against nerves, which can be linked to certain neuropathies. |
High levels mean the immune system may be attacking nerve coverings, which can be seen in some types of neuropathy.
Low levels mean there is little or no antibody activity against myelin-associated glycoprotein, making immune-related nerve damage less likely. |
| IgM | Negative | IgM is a type of antibody that can signal immune system activity. When found in high amounts against myelin-associated glycoprotein, it may point to an autoimmune process affecting the nerves. |
High levels mean there may be an ongoing immune response targeting nerve tissue, which can cause nerve symptoms.
Low levels mean there is little or no immune response detected, which is typical in people without nerve-related autoimmune activity. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Antimyelin Associated Glycoprotein, IgM (Mag Ab) FAQ
Is there Antimyelin Associated Glycoprotein, IgM (Mag Ab) testing near me?
You can find nearby locations for Antimyelin Associated Glycoprotein, IgM (Mag Ab) using the patient service center locator, which also lists mobile phlebotomy options. For people with nerve symptoms that make travel or long waits difficult, having a convenient site makes sample collection much easier and less stressful.
What is the cost of the test?
The price you see for the Antimyelin Associated Glycoprotein, IgM (Mag Ab) test includes all fees, including sample collection at patient service center locations. Ordering this test is worth it if you need clear answers about unexplained nerve symptoms that have not improved with other approaches.
How often should I retest?
Retesting is usually recommended every 6 to 12 months if you have ongoing symptoms or if your doctor is monitoring changes in antibody levels. Regular retesting helps track changes in immune activity, which can guide adjustments in treatment or further evaluation.
How accurate is the test?
This test uses enzyme-linked immunosorbent assay (ELISA) to detect IgM antibodies against myelin-associated glycoprotein, with a specificity of 98% and sensitivity of 92%. TrueHealthLabs.com partners with CLIA-certified laboratories to uphold rigorous testing standards for dependable results.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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