Ordering the Gluten Sensitivity/Celiac Screen
Ordering the Gluten Sensitivity/Celiac Screen helps detect immune responses and genetic markers linked to gluten intolerance and celiac disease. This test checks for specific antibodies and genes that can show if gluten is causing problems in your body. Interestingly, some people with celiac disease may not have any stomach symptoms but can still have damage to their small intestine.
When ordering this test, you can expect these specific benefits:
- Identifies both immune and genetic markers for gluten-related conditions
- Helps distinguish between celiac disease and non-celiac gluten sensitivity
- Detects silent or hidden celiac disease, even without obvious symptoms
- Supports early detection to help prevent long-term complications like nutrient deficiencies
- Guides your doctor in making clear decisions about diet and follow-up care
Who Might Benefit from Gluten-Related Antibody and Genetic Testing
People who have ongoing stomach pain, bloating, or diarrhea after eating foods with wheat, barley, or rye may benefit from this test. For example, someone who has tried removing gluten from their meals but still feels tired and has skin rashes could use this test to find out if gluten is the cause.
Ordering this test may also be helpful in these situations:
- Family members of someone diagnosed with celiac disease
- Children with slow growth or delayed puberty
- People with unexplained iron deficiency anemia
- Those with autoimmune conditions like type 1 diabetes or thyroid disease
- People with frequent mouth ulcers, which can sometimes be linked to gluten sensitivity
This test can help you and your doctor find out if gluten is causing your symptoms, so you can make changes that may improve your digestion and energy. Delaying this test could mean missing early signs of celiac disease, which can lead to more serious problems like bone loss or nerve issues if not addressed.
How to Prepare for Gluten-Related Screening
Fasting is not needed for this test, so you can eat and drink as usual before your blood draw. Always follow any instructions your doctor or healthcare provider gives you to make sure your results are as helpful as possible.
Labs Included When Ordering Your Gluten Sensitivity/Celiac Screen
| Test Name | Reference Range | What This Test Measures | Low and High Levels of Gluten Sensitivity/Celiac Screen |
|---|---|---|---|
| Endomysial Antibody IgA | Negative | This test looks for IgA antibodies that attack the lining of the small intestine, which are often present in people with celiac disease. It is highly specific for diagnosing celiac disease. |
High levels mean your immune system is likely reacting to gluten, which is common in celiac disease.
Low levels mean there is little or no immune reaction, making celiac disease less likely. |
| Immunoglobulin A (Total IgA) | 70–400 | This test checks the total amount of IgA antibodies in your blood. It helps make sure your body can produce enough IgA for accurate celiac testing. |
High levels mean your body is making extra IgA, which can happen with some immune conditions.
Low levels mean you may not make enough IgA, which can affect the results of other celiac tests. |
| Tissue Transglutaminase (IgG + IgA) | Negative | This test finds antibodies against tissue transglutaminase, an enzyme targeted in celiac disease. It is the most common screening tool for gluten-related disorders. |
High levels mean your immune system is reacting to gluten, which is a strong sign of celiac disease.
Low levels mean there is little or no immune response, making celiac disease less likely. |
| HLA DQ2 + HLA DQ8 Genetic Test for Celiac Disease | Negative | This test checks for the HLA DQ2 and DQ8 genes, which are needed for celiac disease to develop. Having these genes means you could develop celiac disease, but not everyone with them will. |
High (positive) means you have the genes linked to celiac disease, so you are at risk.
Low (negative) means you do not have these genes, so celiac disease is very unlikely. |
| Gliadin Antibodies IgG + IgA | Negative | This test looks for antibodies against gliadin, a part of gluten. It helps find both celiac disease and non-celiac gluten sensitivity, especially in people with low IgA. |
High levels mean your immune system is reacting to gluten, which can happen in celiac disease or gluten sensitivity.
Low levels mean there is little or no immune response to gluten. |
Reference ranges can change over time. For the most current values, visit the Quest Diagnostics lab test directory.
Gluten Sensitivity/Celiac Screen FAQ
Is there Gluten Sensitivity/Celiac Screen testing near me?
You can find a nearby location for Gluten Sensitivity/Celiac Screen using the patient service center locator, which also lists mobile phlebotomy options. This is helpful if you need quick and easy access to testing, especially if you have ongoing symptoms and want to avoid long travel for sample collection.
What is the cost of the test?
The price for the Gluten Sensitivity/Celiac Screen includes all fees, such as the blood draw at a patient service center. Ordering this test is worth it if you have unexplained stomach issues or symptoms that could be linked to gluten.
How often should I retest?
Retesting is usually recommended every 6 to 12 months if you are monitoring your response to a gluten-free diet or if your symptoms change. Regular testing helps track changes in your antibody levels and can show if your body is healing or if gluten exposure is still happening.
How accurate is the test?
The Gluten Sensitivity/Celiac Screen uses enzyme-linked immunosorbent assay (ELISA) and genetic analysis for antibody and gene detection. The test has a specificity of about 98% and a sensitivity of 95% for celiac disease. TrueHealthLabs.com partners with CLIA-certified laboratories to uphold rigorous testing standards for dependable results.
Important Notes
- This test is not intended for people who have already started a gluten-free diet, as results may not be accurate.
- Always discuss your results with your healthcare provider for proper interpretation and next steps.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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