CIRS- Chronic Inflammatory Response Syndrome Lab Test Panel
What is CIRS?
CIRS stands for Chronic Inflammatory Response Syndrome and is typically associated with biotoxin exposure. Biotoxins are
toxic compounds that are released by a variety of organisms. In humans, these organisms are usually mold, and other chronic infections (many times symptomless).
To help confirm mold exposure, we recommend testing for mycotoxins.
Dr. Shoemaker and CIRS
Dr. Shoemaker is one of the leading experts in CIRS and suggests several lab tests that can give deep insights into what areas of the body the syndrome is affecting. Here is a great article on CIRS.
Below are the more critical CIRS lab tests that are tested in one single panel.
If you need other tests related to CIRS, please contact us.
What’s Being Tested in This CIRS Lab Panel:
- C3a, Complement
- C4a, Complement
- MMP9
- ADH
- Osmolality
- MSH
- VEGF
- TGFb-1
- Leptin
C3a and C4a
C3a and C4a Are very important in the activation of inflammation. When C3 and C4a Are elevated, inflammation is active and can lead to common CIRS symptoms like cognitive brain issues (memory changes, brain fog, trouble thinking), breathing challenges, and fatigue.
MMP9
MMP9 is released By certain white blood cells and helps break down vessel walls so that different substances can get through into tissues like the brain, muscles, joints, etc. In CIRS, we see an overproduction of MMP9, allowing large amounts of inflammatory substances in, creating widespread inflammation.
ADH
Anti-diuretic hormone (ADH), or vasopressin, acts on the kidneys to keep water in the body, preventing dehydration and keeping electrolytes balanced (osmolality). In biotoxin-related (mold) CIRS, patients may urinate more, have excessive thirst, and become dehydrated.
Since electrolytes can become imbalanced with CIRS, this can change the way nerves fire, creating chronic pain, which can further trigger more inflammation.
Leptin
Leptin is a hormone made by fat cells and tells your brain that you are no longer hungry. However, leptin also increased the amount of fat stored, promoting weight gain. In CIRS, inflammation blocks leptin in the brain thus increasing hunger and weight gain.
MSH
MSH stands for Melanocyte Stimulating Hormone. Secreted by the pituitary gland, this hormone helps control the inflammatory process and fights microbes like mold, which produces biotoxins that lead to CIRS.
The hormone leptin (above) helps produce MSH. Low MSH will aggravate conditions like mold susceptibility, chronic fatigue, chronic pain, insomnia, and hormonal imbalances.
VEGF
VEGF (Vascular Endothelial Growth Factor) is released to help new blood vessels grow in areas of low oxygen. Chronic inflammation lowers VEGF, which means lower oxygen levels in tissues. This can lead to cramping, extreme exhaustion after exercise, and even difficulty breathing.
TGFb-1
TGFb-1 and produce or reduce inflammation. High levels of TGFb-1 happen in overactive immune activity. It can also damage other white blood cells that protect us from autoimmunity, leading to an increased risk.
Frequently Asked Questions For The Chronic Inflammatory Response Syndrome (CIRS) Lab Test
What is Chronic Inflammatory Response Syndrome (CIRS)?
CIRS is a complex, multi-symptom illness triggered by exposure to biotoxins such as mold, bacteria, or other pathogens. It often affects individuals with a genetic predisposition and can lead to a chronic inflammatory response.
Why should I take the CIRS lab test?
The CIRS lab test is essential for diagnosing and managing Chronic Inflammatory Response Syndrome. It helps identify specific biomarkers that indicate the presence and severity of CIRS.
How do I prepare for the CIRS lab test?
No special preparation is required for the CIRS lab test. However, it’s advised to consult with your healthcare provider regarding any medications or supplements you are taking, as may have the potential to affect the test results. If you add on the Vasoactive Intestinal Polypeptide (VIP), a 12 hour fast is needed.
How is the CIRS lab test performed?
The CIRS lab test is performed through a simple blood draw, which is then sent to the laboratory for testing.
How long does it take to get the results?
Results from the CIRS lab test are usually available within 20-22 business days. Your results will by posted under "My Account --> Test Results". You will also receive an email notification when labs are completed.
What do my results mean?
Test results will show whether certain biomarkers are elevated or within normal ranges. Abnormal levels can suggest the presence of CIRS, and your healthcare provider will interpret these results in the context of your symptoms and health history.
Can CIRS be treated?
Yes, CIRS can be managed through a combination of therapies, including addressing the source of biotoxin exposure, detoxification, and immune system support. Including a functional medicine practitioner in your treatment is extremely helpful.
Medical Review Board
Reviewed by Jeff Donohue M.D. from Body Logic and Brady Hurst DC, CCCN. Written by True Health Lab’s team of editorial health contributors.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult your healthcare provider for personalized guidance.
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